КФУ. Карточка публикации. Increasing Severity of Spinal Cord Injury Results in Microglia/Macrophages With Annular-Shaped Morphology and No Change in Expression of CD40 and Tumor Growth Factor-β During the Chronic Post-injury Stage

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INCREASING SEVERITY OF SPINAL CORD INJURY RESULTS IN MICROGLIA/MACROPHAGES WITH ANNULAR-SHAPED MORPHOLOGY AND NO CHANGE IN EXPRESSION OF CD40 AND TUMOR GROWTH FACTOR-β DURING THE CHRONIC POST-INJURY STAGE

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2022

Авторы, сотрудники КФУ

Архипова Светлана Сергеевна, автор

Ризванов Альберт Анатольевич, автор

Рогожин Александр Александрович, автор

Другие авторы

Victoria James

Авторы, аспиранты КФУ

Ахметзянова Эльвира Руслановна, автор

Костенников Александр Александрович, автор

Сабиров Давран Худайшукурович, автор

Библиографическое описание на языке оригинала

Akhmetzyanova E.R, Timofeeva A.V, Sabirov D.K, Increasing Severity of Spinal Cord Injury Results in Microglia/Macrophages With Annular-Shaped Morphology and No Change in Expression of CD40 and Tumor Growth Factor-β During the Chronic Post-injury Stage//Frontiers in Molecular Neuroscience. - 2022. - Vol.14, Is.. - Art. №802558.

Аннотация

Determination of the quantitative composition of phenotypically and morphologically different populations of resident microglia and infiltrating macrophages in spinal cord injury (SCI) of various degrees of severity could lead to much needed novel therapeutic interventions in neurotrauma. In this regard, we investigated the CD40 and TGF-β expressing populations of microglia/macrophages and their morphological states in a rat model of SCI of varying severity. We are the first to describe the annular-shaped microglia/macrophages, the morphology of which was formed due to the spatial orientation of the processes that form round or oval micro-territories, which include disintegrating myelin fibers. This type of cell morphology was found only in the injured spinal cord and mainly in the white matter. At the same time, an assessment of the number of annular-shaped microglia/macrophages and the diameter of micro-territories formed by their processes showed an elevation in these indicators as

Ключевые слова

spinal cord injury, microglia, rat, polarization, morphology

Название журнала

Frontiers in Molecular Neuroscience

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https://repository.kpfu.ru/?p_id=265444

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Архипова Светлана Сергеевна	ru_RU
dc.contributor.author	Ризванов Альберт Анатольевич	ru_RU
dc.contributor.author	Рогожин Александр Александрович	ru_RU
dc.contributor.author	Ахметзянова Эльвира Руслановна	ru_RU
dc.contributor.author	Костенников Александр Александрович	ru_RU
dc.contributor.author	Сабиров Давран Худайшукурович	ru_RU
dc.date.accessioned	2022-01-01T00:00:00Z	ru_RU
dc.date.available	2022-01-01T00:00:00Z	ru_RU
dc.date.issued	2022	ru_RU
dc.identifier.citation	Akhmetzyanova E.R, Timofeeva A.V, Sabirov D.K, Increasing Severity of Spinal Cord Injury Results in Microglia/Macrophages With Annular-Shaped Morphology and No Change in Expression of CD40 and Tumor Growth Factor-β During the Chronic Post-injury Stage//Frontiers in Molecular Neuroscience. - 2022. - Vol.14, Is.. - Art. №802558.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=265444	ru_RU
dc.description.abstract	Frontiers in Molecular Neuroscience	ru_RU
dc.description.abstract	Determination of the quantitative composition of phenotypically and morphologically different populations of resident microglia and infiltrating macrophages in spinal cord injury (SCI) of various degrees of severity could lead to much needed novel therapeutic interventions in neurotrauma. In this regard, we investigated the CD40 and TGF-β expressing populations of microglia/macrophages and their morphological states in a rat model of SCI of varying severity. We are the first to describe the annular-shaped microglia/macrophages, the morphology of which was formed due to the spatial orientation of the processes that form round or oval micro-territories, which include disintegrating myelin fibers. This type of cell morphology was found only in the injured spinal cord and mainly in the white matter. At the same time, an assessment of the number of annular-shaped microglia/macrophages and the diameter of micro-territories formed by their processes showed an elevation in these indicators as	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	spinal cord injury	ru_RU
dc.subject	microglia	ru_RU
dc.subject	rat	ru_RU
dc.subject	polarization	ru_RU
dc.subject	morphology	ru_RU
dc.title	Increasing Severity of Spinal Cord Injury Results in Microglia/Macrophages With Annular-Shaped Morphology and No Change in Expression of CD40 and Tumor Growth Factor-β During the Chronic Post-injury Stage	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU