КФУ. Карточка публикации. Design, Spectral Characteristics, Photostability, and Possibilities for Practical Application of BODIPY FL-Labeled Thioterpenoid

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DESIGN, SPECTRAL CHARACTERISTICS, PHOTOSTABILITY, AND POSSIBILITIES FOR PRACTICAL APPLICATION OF BODIPY FL-LABELED THIOTERPENOID

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2022

Язык

английский

Авторы, сотрудники КФУ

Павельев Роман Сергеевич, автор

Библиографическое описание на языке оригинала

Guseva, G.B. Design, Spectral Characteristics, Photostability, and Possibilities for Practical Application of BODIPY FL-Labeled Thioterpenoid / G.B. Guseva, E.V. Antina, M.B. Berezin, A.S. Smirnova, R.S. Pavelyev, I.R. Gilfanov, O.G. Shevchenko, S.V. Pestova, E.S. Izmest'ev, S.A. Rubtsova, O.V. Ostolopovskaya, S.V. Efimov, V.V. Klochkov, I.Z. Rakhmatullin, A.F. Timerova, I.A. Khodov, O.A. Lodochnikova, D.R. Islamov, P.V. Dorovatovskii, L.E. Nikitina, S.V. Boichuk // Bioengineering, 2022, 9, 210.

Аннотация

Bioengineering

Ключевые слова

fluorescent biomarker; BODIPY dyes; thioterpenoid; erythrocytes; spectral properties; membranotropic effect

Название журнала

Bioengineering

URL

https://www.mdpi.com/2306-5354/9/5/210/htm

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https://repository.kpfu.ru/?p_id=268761

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Павельев Роман Сергеевич	ru_RU
dc.date.accessioned	2022-01-01T00:00:00Z	ru_RU
dc.date.available	2022-01-01T00:00:00Z	ru_RU
dc.date.issued	2022	ru_RU
dc.identifier.citation	Guseva, G.B. Design, Spectral Characteristics, Photostability, and Possibilities for Practical Application of BODIPY FL-Labeled Thioterpenoid / G.B. Guseva, E.V. Antina, M.B. Berezin, A.S. Smirnova, R.S. Pavelyev, I.R. Gilfanov, O.G. Shevchenko, S.V. Pestova, E.S. Izmest'ev, S.A. Rubtsova, O.V. Ostolopovskaya, S.V. Efimov, V.V. Klochkov, I.Z. Rakhmatullin, A.F. Timerova, I.A. Khodov, O.A. Lodochnikova, D.R. Islamov, P.V. Dorovatovskii, L.E. Nikitina, S.V. Boichuk // Bioengineering, 2022, 9, 210.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=268761	ru_RU
dc.description.abstract	Bioengineering	ru_RU
dc.description.abstract	This paper presents the design and a comparative analysis of the structural and solvation factors on the spectral and biological properties of the BODIPY biomarker with a thioterpene fragment. Covalent binding of the thioterpene moiety to the butanoic acid residue of meso-substituted BODIPY was carried out to find out the membranotropic effect of conjugate to erythrocytes, and to assess the possibilities of its practical application in bioimaging. The molecular structure of the conjugate was confirmed via X-ray, UV/vis-, NMR-, and MS-spectra. It was found that dye demonstrates high photostability and high fluorescence quantum yield (to ~100%) at 514–519 nm. In addition, the marker was shown to effectively penetrate the erythrocytes membrane in the absence of erythrotoxicity. The conjugation of BODIPY with thioterpenoid is an excellent way to increase affinity dyes to biostructures, including blood components.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	Design, Spectral Characteristics, Photostability, and Possibilities for Practical Application of BODIPY FL-Labeled Thioterpenoid	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU