| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2022 |
| Язык | английский |
|
Аганов Альберт Вартанович, автор
Арнст Никита Игоревич, автор
Киясов Андрей Павлович, автор
Кочнева Анастасия Анатольевна, автор
Мельникова Анастасия Александровна, автор
Осин Юрий Николаевич, автор
Титова Ангелина Андреевна, автор
Федосимова Светлана Владимировна, автор
Шайхутдинов Нурислам Маратович, автор
|
|
Павельев Михаил , автор
|
|
Липачев Никита Сергеевич, автор
|
|
Двоеглазова Анастасия Сергеевна, автор
|
| Библиографическое описание на языке оригинала |
Lipachev, N. Postnatal development of the microstructure of cortical GABAergic synapses and perineuronal nets requires sensory input / N. Lipachev, A. Melnikova, S. Kuznetsova, N. Arnst, A. Kochneva, N. Shaikhutdinov, A. Dvoeglazova, A. Titova, M. Mavlikeev, A.V. Aganov, Yu.N. Osin, A.P. Kiyasov, M. Paveliev // Neuroscience Research. – 2022. – V.182. – P. 32–40 |
| Аннотация |
The brain synaptic circuitry is formed as a result of pre-defined genetic programs and sensory experience during
postnatal development. Perineuronal nets ensheath synaptic boutons and control several crucial features of the
synapse physiology. Formation of the perineuronal net microstructure during the brain development remains
largely unstudied. Here we provide a detailed quantitative description of the 3-dimensional geometry of the
synapse and the surrounding perineuronal net in the mouse somatosensory cortex layer IV. We compare the
morphology of the synapse+perineuronal net complex in the adult brain formed under normal conditions or in
the whisker shaving model of somatosensory deprivation. We demonstrate that the sensory deprivation causes
flattening of the 3D PNN mesh geometry and reduction of the VGAT-positive cluster volume in presynaptic
boutons. These results reveal a mechanism of the sensory input-dependent synapse morphogenesis during the
brain development. |
| Ключевые слова |
Perineuronal nets, GABAergic synapses, Postnatal development, Quantitative analysis |
| Название журнала |
NEUROSCIENCE
|
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=273329 |
| Файлы ресурса | |
|
|
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Аганов Альберт Вартанович |
ru_RU |
| dc.contributor.author |
Арнст Никита Игоревич |
ru_RU |
| dc.contributor.author |
Киясов Андрей Павлович |
ru_RU |
| dc.contributor.author |
Кочнева Анастасия Анатольевна |
ru_RU |
| dc.contributor.author |
Мельникова Анастасия Александровна |
ru_RU |
| dc.contributor.author |
Осин Юрий Николаевич |
ru_RU |
| dc.contributor.author |
Титова Ангелина Андреевна |
ru_RU |
| dc.contributor.author |
Федосимова Светлана Владимировна |
ru_RU |
| dc.contributor.author |
Шайхутдинов Нурислам Маратович |
ru_RU |
| dc.contributor.author |
Павельев Михаил |
ru_RU |
| dc.contributor.author |
Двоеглазова Анастасия Сергеевна |
ru_RU |
| dc.contributor.author |
Липачев Никита Сергеевич |
ru_RU |
| dc.date.accessioned |
2022-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2022-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2022 |
ru_RU |
| dc.identifier.citation |
Lipachev, N. Postnatal development of the microstructure of cortical GABAergic synapses and perineuronal nets requires sensory input / N. Lipachev, A. Melnikova, S. Kuznetsova, N. Arnst, A. Kochneva, N. Shaikhutdinov, A. Dvoeglazova, A. Titova, M. Mavlikeev, A.V. Aganov, Yu.N. Osin, A.P. Kiyasov, M. Paveliev // Neuroscience Research. – 2022. – V.182. – P. 32–40 |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=273329 |
ru_RU |
| dc.description.abstract |
NEUROSCIENCE |
ru_RU |
| dc.description.abstract |
The brain synaptic circuitry is formed as a result of pre-defined genetic programs and sensory experience during
postnatal development. Perineuronal nets ensheath synaptic boutons and control several crucial features of the
synapse physiology. Formation of the perineuronal net microstructure during the brain development remains
largely unstudied. Here we provide a detailed quantitative description of the 3-dimensional geometry of the
synapse and the surrounding perineuronal net in the mouse somatosensory cortex layer IV. We compare the
morphology of the synapse+perineuronal net complex in the adult brain formed under normal conditions or in
the whisker shaving model of somatosensory deprivation. We demonstrate that the sensory deprivation causes
flattening of the 3D PNN mesh geometry and reduction of the VGAT-positive cluster volume in presynaptic
boutons. These results reveal a mechanism of the sensory input-dependent synapse morphogenesis during the
brain development. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
Perineuronal nets |
ru_RU |
| dc.subject |
GABAergic synapses |
ru_RU |
| dc.subject |
Postnatal development |
ru_RU |
| dc.subject |
Quantitative analysis |
ru_RU |
| dc.title |
Postnatal development of the microstructure of cortical GABAergic synapses and perineuronal nets requires sensory input |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
|
EN 
中文 
ES 
Карта сайта
