| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2022 |
| Язык | английский |
|
Яруллина Дина Рашидовна, автор
|
| Библиографическое описание на языке оригинала |
Anisimova E, Gorokhova I, Karimullina G, Alarming Antibiotic Resistance of Lactobacilli Isolated from Probiotic Preparations and Dietary Supplements//Antibiotics. - 2022. - Vol.11, Is.11. - Art. №1557. |
| Аннотация |
In this study we screened eight commercially available brands of Lactobacillus-containing probiotic preparations and dietary supplements for resistance towards commonly administered antibiotics of different classes. According to the results of disc diffusion method, most of the isolates were resistant to vancomycin and susceptible to penicillin-type antibiotics (ampicillin and amoxicillin), carbapenems (imipenem, meropenem, and ertapenem), and inhibitors of protein synthesis (chloramphenicol, erythromycin, tetracycline, clarithromycin, and linezolid). Yet, based on the minimum inhibitory concentration (MIC) values six strains were reconsidered as resistant to tetracycline. All tested lactobacilli were resistant towards amikacin, ciprofloxacin, and norfloxacin. Resistance to cephalosporins was highly variable and decreased in a row: ceftazidime/cefepime, ceftriaxone, cefotaxime, cefazolin, and cefoperazone. PCR screening for antibiotic resistance de-terminants in probiotic lactobacilli revealed wide occurrence of vancomycin resistance gene vanX, ciprofloxacin resistance gene parC, and extended-spectrum β-lactamase gene blaTEM. We also de-tected tetK gene for tetracycline resistance in one isolate. Additionally, for several products we demonstrated discrepancies between the claims of the manufacturers and the identified species composition, as well as enumerated amount of viable bacteria. The results of this study raise concern about safety of lactobacilli for human consumption as probiotics since they may act as reservoirs of transferable antibiotic resistance genes. |
| Ключевые слова |
Lactobacilli, probiotics, safety, antibiotic resistance, resistance genes. |
| Название журнала |
Antibiotics
|
| URL |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85141757017&doi=10.3390%2fantibiotics11111557&partnerID=40&md5=b94d3cecdb26b2739633126496af578b |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=274286 |
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Яруллина Дина Рашидовна |
ru_RU |
| dc.date.accessioned |
2022-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2022-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2022 |
ru_RU |
| dc.identifier.citation |
Anisimova E, Gorokhova I, Karimullina G, Alarming Antibiotic Resistance of Lactobacilli Isolated from Probiotic Preparations and Dietary Supplements//Antibiotics. - 2022. - Vol.11, Is.11. - Art. №1557. |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=274286 |
ru_RU |
| dc.description.abstract |
Antibiotics |
ru_RU |
| dc.description.abstract |
In this study we screened eight commercially available brands of Lactobacillus-containing probiotic preparations and dietary supplements for resistance towards commonly administered antibiotics of different classes. According to the results of disc diffusion method, most of the isolates were resistant to vancomycin and susceptible to penicillin-type antibiotics (ampicillin and amoxicillin), carbapenems (imipenem, meropenem, and ertapenem), and inhibitors of protein synthesis (chloramphenicol, erythromycin, tetracycline, clarithromycin, and linezolid). Yet, based on the minimum inhibitory concentration (MIC) values six strains were reconsidered as resistant to tetracycline. All tested lactobacilli were resistant towards amikacin, ciprofloxacin, and norfloxacin. Resistance to cephalosporins was highly variable and decreased in a row: ceftazidime/cefepime, ceftriaxone, cefotaxime, cefazolin, and cefoperazone. PCR screening for antibiotic resistance de-terminants in probiotic lactobacilli revealed wide occurrence of vancomycin resistance gene vanX, ciprofloxacin resistance gene parC, and extended-spectrum β-lactamase gene blaTEM. We also de-tected tetK gene for tetracycline resistance in one isolate. Additionally, for several products we demonstrated discrepancies between the claims of the manufacturers and the identified species composition, as well as enumerated amount of viable bacteria. The results of this study raise concern about safety of lactobacilli for human consumption as probiotics since they may act as reservoirs of transferable antibiotic resistance genes. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
Lactobacilli |
ru_RU |
| dc.subject |
probiotics |
ru_RU |
| dc.subject |
safety |
ru_RU |
| dc.subject |
antibiotic resistance |
ru_RU |
| dc.subject |
resistance genes. |
ru_RU |
| dc.title |
Alarming Antibiotic Resistance of Lactobacilli Isolated from Probiotic Preparations and Dietary Supplements |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
|
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