| Форма представления | Статьи в российских журналах и сборниках |
| Год публикации | 2022 |
| Язык | английский |
|
Гатиатулин Аскар Камилевич, автор
Горбачук Валерий Виленович, автор
Зиганшин Марат Ахмедович, автор
Климовицкий Александр Евгеньевич, автор
Осельская Виктория Юрьевна, автор
|
| Библиографическое описание на языке оригинала |
Osel'skaya, V. Yu. Competing Role of Water in Inclusion of Indomethacin and Volatile Organic Compounds by Native Cyclodextrins/ V. Yu. Osel'skaya, A. K. Gatiatulin, A. E. Klimovitskii, M. A. Ziganshin, V. V. Gorbatchuk //Macroheterocycles. - 2022. –V.15, N3. – P.174-185. – DOI: 10.6060/mhc224319g. |
| Аннотация |
The hydration was found to reduce an efficiency of drug encapsulation by native cyclodextrins (CDs) when water is added above a certain threshold level. The hydration water competes with indomethacin for solid-phase inclusion in γ-cyclodextrin (γCD) and β-cyclodextrin (βCD) with an increase of water contents to the saturation level. No competing effect was observed for α-cyclodextrin (αCD) with this drug. The hydration effect for indomethacin correlates with the influence of hydration water on inclusion of volatile organic guests by native CDs. For these guests and γCD, the competing hydration effect was estimated also by determination of vapor sorption isotherms and was found higher than that for βCD but in most cases lower than such effect for αCD. The inclusion affinity and capacity of dried γCD for water and organic guests were determined and a significant size exclusion effect was observed, which contributes to the water-guest competition. The ratio between competing and activation roles of water for the studied three native cyclodextrins correlates with the parameters of their unit cells in hydrates and in dried state. |
| Ключевые слова |
γ-cyclodextrin, β-cyclodextrin, α-cyclodextrin, indomethacin, inclusion compound, encapsulation |
| Название журнала |
Макрогетероциклы
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| URL |
http://mhc-isuct.ru/article/view/4319 |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=275329 |
| Файлы ресурса | |
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Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Гатиатулин Аскар Камилевич |
ru_RU |
| dc.contributor.author |
Горбачук Валерий Виленович |
ru_RU |
| dc.contributor.author |
Зиганшин Марат Ахмедович |
ru_RU |
| dc.contributor.author |
Климовицкий Александр Евгеньевич |
ru_RU |
| dc.contributor.author |
Осельская Виктория Юрьевна |
ru_RU |
| dc.date.accessioned |
2022-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2022-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2022 |
ru_RU |
| dc.identifier.citation |
Osel'skaya, V. Yu. Competing Role of Water in Inclusion of Indomethacin and Volatile Organic Compounds by Native Cyclodextrins/ V. Yu. Osel'skaya, A. K. Gatiatulin, A. E. Klimovitskii, M. A. Ziganshin, V. V. Gorbatchuk //Macroheterocycles. - 2022. –V.15, N3. – P.174-185. – DOI: 10.6060/mhc224319g. |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=275329 |
ru_RU |
| dc.description.abstract |
Макрогетероциклы |
ru_RU |
| dc.description.abstract |
The hydration was found to reduce an efficiency of drug encapsulation by native cyclodextrins (CDs) when water is added above a certain threshold level. The hydration water competes with indomethacin for solid-phase inclusion in γ-cyclodextrin (γCD) and β-cyclodextrin (βCD) with an increase of water contents to the saturation level. No competing effect was observed for α-cyclodextrin (αCD) with this drug. The hydration effect for indomethacin correlates with the influence of hydration water on inclusion of volatile organic guests by native CDs. For these guests and γCD, the competing hydration effect was estimated also by determination of vapor sorption isotherms and was found higher than that for βCD but in most cases lower than such effect for αCD. The inclusion affinity and capacity of dried γCD for water and organic guests were determined and a significant size exclusion effect was observed, which contributes to the water-guest competition. The ratio between competing and activation roles of water for the studied three native cyclodextrins correlates with the parameters of their unit cells in hydrates and in dried state. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
γ-cyclodextrin |
ru_RU |
| dc.subject |
β-cyclodextrin |
ru_RU |
| dc.subject |
α-cyclodextrin |
ru_RU |
| dc.subject |
indomethacin |
ru_RU |
| dc.subject |
inclusion compound |
ru_RU |
| dc.subject |
encapsulation |
ru_RU |
| dc.title |
Competing Role of Water in Inclusion of Indomethacin and Volatile Organic Compounds by Native Cyclodextrins
|
ru_RU |
| dc.type |
Статьи в российских журналах и сборниках |
ru_RU |
|
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