| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2022 |
| Язык | английский |
|
Яруллина Дина Рашидовна, автор
|
| Библиографическое описание на языке оригинала |
Yarullina Dina, Pankratova Yuliia, Karaseva Olga, Grigoryeva T, Karpukhin O. Microbiota of the Colonic Diverticula in the Complicated Form of Diverticulitis: A Case Report//LIFE. - 2022. - Vol.12, Is.12. - Art. №2129. |
| Аннотация |
Intestinal microbiota appears to be implicated in the pathogenesis of diverticular disease.
We present the case of a patient with diverticular colon disease complicated by a pelvic abscess.
During the successful surgical treatment, two specimens were taken from the resected colon segment
for the microbiota analysis: an inflamed and perforated diverticulum and a diverticulum without
signs of inflammation. Culturing and 16S rRNA gene sequencing revealed significant changes
in the microbial community structure and composition associated with the acute inflammation
and perforation of the colonic diverticulum. The characteristics that are usually associated with
the inflammatory process in the gut, namely reduced microbial diversity and richness, decreased
Firmicutes-to-Bacteroidetes (F/B) ratio, depletion of butyrate-producing bacteria, and Enterobacteriaceae
blooming, were more pronounced in the non-inflamed diverticulum rather than in the adjacent
inflamed and perforated one. This is the first study of the intraluminal microbiota of the diverticular
pockets, which is more relevant to the etiology of diverticular disease than mucosa-associated microbiota via biopsies and luminal microbiota via fecal samples. |
| Ключевые слова |
diverticulitis, inflamed diverticulum, non-inflamed diverticulum, microbiota |
| Название журнала |
Life
|
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=278456 |
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Яруллина Дина Рашидовна |
ru_RU |
| dc.date.accessioned |
2022-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2022-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2022 |
ru_RU |
| dc.identifier.citation |
Yarullina Dina, Pankratova Yuliia, Karaseva Olga, Grigoryeva T, Karpukhin O. Microbiota of the Colonic Diverticula in the Complicated Form of Diverticulitis: A Case Report//LIFE. - 2022. - Vol.12, Is.12. - Art. №2129. |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=278456 |
ru_RU |
| dc.description.abstract |
Life |
ru_RU |
| dc.description.abstract |
Intestinal microbiota appears to be implicated in the pathogenesis of diverticular disease.
We present the case of a patient with diverticular colon disease complicated by a pelvic abscess.
During the successful surgical treatment, two specimens were taken from the resected colon segment
for the microbiota analysis: an inflamed and perforated diverticulum and a diverticulum without
signs of inflammation. Culturing and 16S rRNA gene sequencing revealed significant changes
in the microbial community structure and composition associated with the acute inflammation
and perforation of the colonic diverticulum. The characteristics that are usually associated with
the inflammatory process in the gut, namely reduced microbial diversity and richness, decreased
Firmicutes-to-Bacteroidetes (F/B) ratio, depletion of butyrate-producing bacteria, and Enterobacteriaceae
blooming, were more pronounced in the non-inflamed diverticulum rather than in the adjacent
inflamed and perforated one. This is the first study of the intraluminal microbiota of the diverticular
pockets, which is more relevant to the etiology of diverticular disease than mucosa-associated microbiota via biopsies and luminal microbiota via fecal samples. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
diverticulitis |
ru_RU |
| dc.subject |
inflamed diverticulum |
ru_RU |
| dc.subject |
non-inflamed diverticulum |
ru_RU |
| dc.subject |
microbiota |
ru_RU |
| dc.title |
Microbiota of the Colonic Diverticula in the Complicated Form of Diverticulitis: A Case Report |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
|
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