| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2023 |
| Язык | английский |
|
Сабирова Диана Эмилевна, автор
Саченков Оскар Александрович, автор
Чернова Ольга Николаевна, автор
|
|
Сабирова Диана Эмилевна, автор
|
| Библиографическое описание на языке оригинала |
Baltin, M.E. Morphofunctional Changes in the Spinal Cord of Rats after Contusion Injury with Local Delivery of Methylprednisolone in Combination with a Copolymer/M.E. Baltin, D.E.Sabirova, O.N.Chernova, T. V. Baltina, O. A. Sachenkov //Bull Exp Biol Med. - 2023. - Vol.174. - P. 810–815. |
| Аннотация |
We studied the neuroprotective effect of local application of methylprednisolone in combination with a block copolymer after contusion spinal cord injury in rats. Histological analysis of the spinal cord showed that delivery of a complex of methylprednisolone with a block copolymer reduced the volume of white and gray matter lesions. An increase in the amplitude of the evoked response of the gastrocnemius muscle was observed during epidural stimulation of the spinal cord 6 h after the injury. The maximum amplitude of the muscle response was
greater in the group with local delivery of the methylprednisolone complex with the polymer 72 h after the injury. The obtained results demonstrate the neuroprotective effect of the local administration of the complex and allow to make positive prognosis for the recovery of the
sensorimotor functions in rats. |
| Ключевые слова |
spinal cord injury, methylprednisolone, trifunctional block copolymer, morphometric analysis, evoked muscle responses |
| Название журнала |
B EXP BIOL MED+
|
| URL |
https://link.springer.com/article/10.1007/s10517-023-05795-1 |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=280693 |
| Файлы ресурса | |
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|
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Сабирова Диана Эмилевна |
ru_RU |
| dc.contributor.author |
Саченков Оскар Александрович |
ru_RU |
| dc.contributor.author |
Чернова Ольга Николаевна |
ru_RU |
| dc.contributor.author |
Сабирова Диана Эмилевна |
ru_RU |
| dc.date.accessioned |
2023-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2023-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2023 |
ru_RU |
| dc.identifier.citation |
Baltin, M.E. Morphofunctional Changes in the Spinal Cord of Rats after Contusion Injury with Local Delivery of Methylprednisolone in Combination with a Copolymer/M.E. Baltin, D.E.Sabirova, O.N.Chernova, T. V. Baltina, O. A. Sachenkov //Bull Exp Biol Med. - 2023. - Vol.174. - P. 810–815. |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=280693 |
ru_RU |
| dc.description.abstract |
B EXP BIOL MED+ |
ru_RU |
| dc.description.abstract |
We studied the neuroprotective effect of local application of methylprednisolone in combination with a block copolymer after contusion spinal cord injury in rats. Histological analysis of the spinal cord showed that delivery of a complex of methylprednisolone with a block copolymer reduced the volume of white and gray matter lesions. An increase in the amplitude of the evoked response of the gastrocnemius muscle was observed during epidural stimulation of the spinal cord 6 h after the injury. The maximum amplitude of the muscle response was
greater in the group with local delivery of the methylprednisolone complex with the polymer 72 h after the injury. The obtained results demonstrate the neuroprotective effect of the local administration of the complex and allow to make positive prognosis for the recovery of the
sensorimotor functions in rats. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
spinal cord injury |
ru_RU |
| dc.subject |
methylprednisolone |
ru_RU |
| dc.subject |
trifunctional block copolymer |
ru_RU |
| dc.subject |
morphometric analysis |
ru_RU |
| dc.subject |
evoked muscle responses |
ru_RU |
| dc.title |
Morphofunctional Changes in the Spinal Cord of Rats after Contusion Injury with Local Delivery of Methylprednisolone in Combination with a Copolymer |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
|
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