| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2022 |
|
Блатт Наталия Львовна, автор
|
| Другие авторы |
Абдулганиева Диана Ильдаровна, Мухаметова Диляра Дамировна, Валеева Илдария Хайрулловна, Зинкевич Олег Данилович, Сафина Нэлля Ахметовна, Одинцова Альфия Харисовна |
|
Коровина Марина Олеговна, автор
|
| Библиографическое описание на языке оригинала |
Abdulganieva D.I., Mukhametova D.D., Valeeva I. K, Blatt N., Zinkevich?O.D., Safina N.A., Odintsova A. Kh., Korovina M.O. Faecal Neutrophil Gelatinase associated Lipocalin as a Non invasive Biomarker in Inflammatory Bowel Disease // BioNanoSciencе (2022). 12:1381?1387 https://doi.org/10.1007/s12668-022-00999-7 |
| Аннотация |
The aim was to evaluate NGAL level in faeces in patients with IBD. We included 107 patients with IBD ? 96 cases of IBD flare up (66 ? UC and 29 ? CD), 11 patients in IBD remission (6 ? UC and 6 ? CD) and 30 healthy controls. There was a confirmed faecal NGAL level in all patients. Faecal NGAL was significantly higher in active IBD ? 4122 [861; 6850] ng/ml comparing with healthy persons ? 181 [169; 720] ng/ml (p < 0,001) or inactive IBD ? 1136 [116; 3004] ng/ml (p < 0,05). In active UC (4668 [1298; 7792] ng/ml), it was higher than in active CD (2688 [200; 5710] ng/ml) (p < 0.05). We found that faecal NGAL as a marker has sensitivity of 72.9%, specificity of 93.3% and AUC of 0.88 for distinguishing IBD from healthies. Sensitivity, specificity and AUC were 72.9%, 45.5% and 0.72, respectively, for distinguishing exacerbation from remission of disease. Faecal NGAL is a new promising marker for diagnosis active IBD, which has high sensitivity, specificity and AUC. |
| Ключевые слова |
Infammatory bowel disease, Crohn?s disease, Ulcerative colitis, Lipocalin-2 ,Neutrophil gelatinase-associated lipocalin, NGAL |
| Название журнала |
BioNanoScience
|
| Издательство |
Springer |
| URL |
https://link.springer.com/article/10.1007/s12668-022-00999-7 |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=281652 |
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Блатт Наталия Львовна |
ru_RU |
| dc.contributor.author |
Коровина Марина Олеговна |
ru_RU |
| dc.date.accessioned |
2022-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2022-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2022 |
ru_RU |
| dc.identifier.citation |
Abdulganieva D.I., Mukhametova D.D., Valeeva I. K, Blatt N., Zinkevich?O.D., Safina N.A., Odintsova A. Kh., Korovina M.O. Faecal Neutrophil Gelatinase associated Lipocalin as a Non invasive Biomarker in Inflammatory Bowel Disease // BioNanoSciencе (2022). 12:1381?1387 https://doi.org/10.1007/s12668-022-00999-7 |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=281652 |
ru_RU |
| dc.description.abstract |
BioNanoScience |
ru_RU |
| dc.description.abstract |
The aim was to evaluate NGAL level in faeces in patients with IBD. We included 107 patients with IBD ? 96 cases of IBD flare up (66 ? UC and 29 ? CD), 11 patients in IBD remission (6 ? UC and 6 ? CD) and 30 healthy controls. There was a confirmed faecal NGAL level in all patients. Faecal NGAL was significantly higher in active IBD ? 4122 [861; 6850] ng/ml comparing with healthy persons ? 181 [169; 720] ng/ml (p < 0,001) or inactive IBD ? 1136 [116; 3004] ng/ml (p < 0,05). In active UC (4668 [1298; 7792] ng/ml), it was higher than in active CD (2688 [200; 5710] ng/ml) (p < 0.05). We found that faecal NGAL as a marker has sensitivity of 72.9%, specificity of 93.3% and AUC of 0.88 for distinguishing IBD from healthies. Sensitivity, specificity and AUC were 72.9%, 45.5% and 0.72, respectively, for distinguishing exacerbation from remission of disease. Faecal NGAL is a new promising marker for diagnosis active IBD, which has high sensitivity, specificity and AUC. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.publisher |
Springer |
ru_RU |
| dc.subject |
Infammatory bowel disease |
ru_RU |
| dc.subject |
Crohn?s disease |
ru_RU |
| dc.subject |
Ulcerative colitis |
ru_RU |
| dc.subject |
Lipocalin-2 |
ru_RU |
| dc.subject |
Neutrophil gelatinase-associated lipocalin |
ru_RU |
| dc.subject |
NGAL |
ru_RU |
| dc.title |
Faecal Neutrophil Gelatinase associated Lipocalin as a Non invasive Biomarker in Inflammatory Bowel Disease |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
|
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