| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2023 |
| Язык | английский |
|
Гатиатулин Аскар Камилевич, автор
Горбачук Валерий Виленович, автор
Зиганшин Марат Ахмедович, автор
Климовицкий Александр Евгеньевич, автор
Осельская Виктория Юрьевна, автор
|
| Библиографическое описание на языке оригинала |
Gatiatulin A. K. Influence Of Hydration And The Size Of The Macrocycle Of Native Cyclodextrins On The Solid Phase Inclusion Of Ritonavir [text] / A.K. Gatiatulin, V.Y. Oselskaya, A.E. Klimovitskii, M.A. Ziganshin, V.V. Gorbachuk // Journal of Structural Chemistry. — 2023. — V. 64(9). — P. 1702–1714. |
| Аннотация |
We study how the size of the macrocycle of native cyclodextrins and their hydration influence the inclusion of ritonavir under mechanical grinding conditions. A procedure is proposed to estimate the degree of inclusion of ritonavir by cyclodextrins using the crystallization of the unincluded guest in the grinding products at the water vapor treatment. Ritonavir is almost completely included by anhydrous α-, β-, and γ-cyclodextrins, resulting in the formation of inclusion compounds. The structure–property relationship between ritonavir inclusion in cyclodextrin hydrates and the size of the host macrocycle is nonlinear. Ritonavir is completely included by saturated β-cyclodextrin hydrate and intermediate γ-cyclodextrin hydrates. The degree of ritonavir inclusion by saturated hydrates of α-cyclodextrin and particularly of γ-cyclodextrin is small due to the competition of this guest with water. |
| Ключевые слова |
ritonavir, cyclodextrins, polymorphism, inclusion compound |
| Название журнала |
Journal of Structural Chemistry
|
| URL |
https://link.springer.com/article/10.1134/S0022476623090135#Bib1 |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=284149 |
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Гатиатулин Аскар Камилевич |
ru_RU |
| dc.contributor.author |
Горбачук Валерий Виленович |
ru_RU |
| dc.contributor.author |
Зиганшин Марат Ахмедович |
ru_RU |
| dc.contributor.author |
Климовицкий Александр Евгеньевич |
ru_RU |
| dc.contributor.author |
Осельская Виктория Юрьевна |
ru_RU |
| dc.date.accessioned |
2023-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2023-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2023 |
ru_RU |
| dc.identifier.citation |
Gatiatulin A. K. Influence Of Hydration And The Size Of The Macrocycle Of Native Cyclodextrins On The Solid Phase Inclusion Of Ritonavir [text] / A.K. Gatiatulin, V.Y. Oselskaya, A.E. Klimovitskii, M.A. Ziganshin, V.V. Gorbachuk // Journal of Structural Chemistry. — 2023. — V. 64(9). — P. 1702–1714. |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=284149 |
ru_RU |
| dc.description.abstract |
Journal of Structural Chemistry |
ru_RU |
| dc.description.abstract |
We study how the size of the macrocycle of native cyclodextrins and their hydration influence the inclusion of ritonavir under mechanical grinding conditions. A procedure is proposed to estimate the degree of inclusion of ritonavir by cyclodextrins using the crystallization of the unincluded guest in the grinding products at the water vapor treatment. Ritonavir is almost completely included by anhydrous α-, β-, and γ-cyclodextrins, resulting in the formation of inclusion compounds. The structure–property relationship between ritonavir inclusion in cyclodextrin hydrates and the size of the host macrocycle is nonlinear. Ritonavir is completely included by saturated β-cyclodextrin hydrate and intermediate γ-cyclodextrin hydrates. The degree of ritonavir inclusion by saturated hydrates of α-cyclodextrin and particularly of γ-cyclodextrin is small due to the competition of this guest with water. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
ritonavir |
ru_RU |
| dc.subject |
cyclodextrins |
ru_RU |
| dc.subject |
polymorphism |
ru_RU |
| dc.subject |
inclusion compound |
ru_RU |
| dc.title |
Influence Of Hydration And The Size Of The Macrocycle Of Native Cyclodextrins On The Solid Phase Inclusion Of Ritonavir |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
|
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