| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2023 |
| Язык | английский |
|
Бузюров Алексей Владимирович, автор
Гатауллина Карина Всеволодовна, автор
Гатиатулин Аскар Камилевич, автор
Герасимов Александр Владимирович, автор
Горбачук Валерий Виленович, автор
Зиганшин Марат Ахмедович, автор
Шик Кристоф Эрик Георг , автор
|
| Библиографическое описание на языке оригинала |
Gataullina K. V; Buzyurov A. V; Gerasimov A. V; Gatiatulin A. K.; Ziganshin M. A.; Schick C.; Gorbatchuk V. V. New Polymorph of Indomethacin: Screening by Solid-State Guest Exchange and Characterization Using Fast Scanning Calorimetry. // Cryst. Growth Des. — 2023. DOI: 10.1021/acs.cgd.3c00443 |
| Аннотация |
Solid-state guest exchange is used as an efficient method to
prepare very metastable polymorphs of indomethacin, including the
polymorph observed earlier only in a mixture with a polymeric solvent and
a new crystalline form of this drug with a negligibly small amount of the
included solvent (guest). The used preparation procedure gives less stable
inclusion compounds of indomethacin, which require a milder desolvation
treatment than inclusion compounds formed in binary host−guest systems,
so the metastable forms with a low first melting point can be prepared. For
the characterization of indomethacin polymorphs, fast scanning calorimetry
was used, along with conventional characterization methods. This method
merges multistep polymorphic transitions, making the first melting point much more pronounced, so the different polymorphs
become better discriminated. |
| Ключевые слова |
indomethacin, polymorphism, pseudopolymorphism, inclusion compound, fast scanning calorimetry |
| Название журнала |
CRYSTAL GROWTH & DESIGN
|
| URL |
https://pubs.acs.org/doi/10.1021/acs.cgd.3c00443 |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=285563 |
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Бузюров Алексей Владимирович |
ru_RU |
| dc.contributor.author |
Гатауллина Карина Всеволодовна |
ru_RU |
| dc.contributor.author |
Гатиатулин Аскар Камилевич |
ru_RU |
| dc.contributor.author |
Герасимов Александр Владимирович |
ru_RU |
| dc.contributor.author |
Горбачук Валерий Виленович |
ru_RU |
| dc.contributor.author |
Зиганшин Марат Ахмедович |
ru_RU |
| dc.contributor.author |
Шик Кристоф Эрик Георг |
ru_RU |
| dc.date.accessioned |
2023-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2023-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2023 |
ru_RU |
| dc.identifier.citation |
Gataullina K. V; Buzyurov A. V; Gerasimov A. V; Gatiatulin A. K.; Ziganshin M. A.; Schick C.; Gorbatchuk V. V. New Polymorph of Indomethacin: Screening by Solid-State Guest Exchange and Characterization Using Fast Scanning Calorimetry. // Cryst. Growth Des. — 2023. DOI: 10.1021/acs.cgd.3c00443 |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=285563 |
ru_RU |
| dc.description.abstract |
CRYSTAL GROWTH & DESIGN |
ru_RU |
| dc.description.abstract |
Solid-state guest exchange is used as an efficient method to
prepare very metastable polymorphs of indomethacin, including the
polymorph observed earlier only in a mixture with a polymeric solvent and
a new crystalline form of this drug with a negligibly small amount of the
included solvent (guest). The used preparation procedure gives less stable
inclusion compounds of indomethacin, which require a milder desolvation
treatment than inclusion compounds formed in binary host−guest systems,
so the metastable forms with a low first melting point can be prepared. For
the characterization of indomethacin polymorphs, fast scanning calorimetry
was used, along with conventional characterization methods. This method
merges multistep polymorphic transitions, making the first melting point much more pronounced, so the different polymorphs
become better discriminated. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
indomethacin |
ru_RU |
| dc.subject |
polymorphism |
ru_RU |
| dc.subject |
pseudopolymorphism |
ru_RU |
| dc.subject |
inclusion compound |
ru_RU |
| dc.subject |
fast scanning calorimetry |
ru_RU |
| dc.title |
New Polymorph of Indomethacin: Screening by Solid-State Guest Exchange and Characterization Using Fast Scanning Calorimetry |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
|
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