КФУ. Карточка публикации. Response of Isolated Rat Heart to ?2-Adrenergic Receptor Stimulation after If Current Blockade in the Late Postinfarction Period

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RESPONSE OF ISOLATED RAT HEART TO ?2-ADRENERGIC RECEPTOR STIMULATION AFTER IF CURRENT BLOCKADE IN THE LATE POSTINFARCTION PERIOD

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2022

Язык

русский

Авторы, сотрудники КФУ

Зефиров Тимур Львович, автор

Зиятдинова Нафиса Ильгизовна, автор

Купцова Анна Михайловна, автор

Авторы, аспиранты КФУ

Бугров Роман Кутдусович, автор

Библиографическое описание на языке оригинала

Bugrov R.K. Response of Isolated Rat Heart to ?2-Adrenergic Receptor Stimulation after If Current Blockade in the Late Postinfarction Period /R.K. Bugrov , A.M. Kuptsova, N.I. Ziyatdinova, T.L. Zefirov // Bulletin of Experimental Biology and Medicine. - 2022. - Vol.174, Is.1. - P.22-25.

Аннотация

We studied the effect of α2-adrenoreceptor activation after preliminary If-current blockade on the performance of the Langendorff-isolated rat heart 54 days after modeling myocardial infarction. Stimulation of α2-adrenoreceptors against the background of application of If blocker ZD7288 in concentrations of 10-9 and 10-5 M decreased myocardial inotropy in isolated rat hearts by 50 and 39% (p<0.05) and increased HR by 20 and 15% (p<0.05), respectively. Activation of α2-adrenoreceptors against the background of application of ZD7288 in a concentration of 10-9 and 10-5 M led to a decrease in the coronary flow in the isolated rat heart with the model of myocardial infarction by 21% (p<0.05) and 32% (p<0.05), respectively.

Ключевые слова

If-currents; isolated heart; myocardial infarction model; rat; α2-adrenergic receptors.

Название журнала

Бюллетень экспериментальной биологии и медицины

URL

https://link.springer.com/article/10.1007/s10517-022-05640-x

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https://repository.kpfu.ru/?p_id=289998

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F_BEBiM_2022_Response_of_Isolated_Rat__eart_to___945_2_Adrenergic_Receptor.pdf	0,42	pdf	посмотреть / скачать

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Зефиров Тимур Львович	ru_RU
dc.contributor.author	Зиятдинова Нафиса Ильгизовна	ru_RU
dc.contributor.author	Купцова Анна Михайловна	ru_RU
dc.contributor.author	Бугров Роман Кутдусович	ru_RU
dc.date.accessioned	2022-01-01T00:00:00Z	ru_RU
dc.date.available	2022-01-01T00:00:00Z	ru_RU
dc.date.issued	2022	ru_RU
dc.identifier.citation	Bugrov R.K. Response of Isolated Rat Heart to ?2-Adrenergic Receptor Stimulation after If Current Blockade in the Late Postinfarction Period /R.K. Bugrov , A.M. Kuptsova, N.I. Ziyatdinova, T.L. Zefirov // Bulletin of Experimental Biology and Medicine. - 2022. - Vol.174, Is.1. - P.22-25.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=289998	ru_RU
dc.description.abstract	Бюллетень экспериментальной биологии и медицины	ru_RU
dc.description.abstract	We studied the effect of α2-adrenoreceptor activation after preliminary If-current blockade on the performance of the Langendorff-isolated rat heart 54 days after modeling myocardial infarction. Stimulation of α2-adrenoreceptors against the background of application of If blocker ZD7288 in concentrations of 10-9 and 10-5 M decreased myocardial inotropy in isolated rat hearts by 50 and 39% (p<0.05) and increased HR by 20 and 15% (p<0.05), respectively. Activation of α2-adrenoreceptors against the background of application of ZD7288 in a concentration of 10-9 and 10-5 M led to a decrease in the coronary flow in the isolated rat heart with the model of myocardial infarction by 21% (p<0.05) and 32% (p<0.05), respectively.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	Response of Isolated Rat Heart to ?2-Adrenergic Receptor Stimulation after If Current Blockade in the Late Postinfarction Period	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU