| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2023 |
| Язык | русский |
|
Зефиров Тимур Львович, автор
Зиятдинова Нафиса Ильгизовна, автор
Крылова Алевтина Васильевна, автор
|
|
Зефиров Андрей Львович, автор
|
|
Леонова Алина Маратовна, автор
|
| Библиографическое описание на языке оригинала |
Galieva A.M. Electrical activity of rat working myocardiocytes during alpha2-adrenoreceptor stimulation / A.M. Galieva, Zefrov A.L., Ziyatdinova N.I., Krylova A.V., Zefirov T.L. // Biophysical Reviews. - 2023. - Vol. 15. - p. 1502 |
| Аннотация |
It is known that isolated rat myocardium contains beta1-adrenoreceptors, beta2-adrenoreceptors, beta3-adrenoreceptors, beta4-adrenoreceptors, as well as alpha1-adrenoreceptors and alpha2-adrenoreceptors.
Research indicate that α2-AR isoforms (α2А-, α2B- and α2C) are expressed in cardiac myocytes with the potential to safeguard cardiac muscle under adrenergic surge by governing intracellular Ca2+
handling and contractility. By adjusting the balance between protein kinase and phosphatase activities, sarcolemmal α2-ARs are capable of counterbalancing signaling cascades that provoke hypertrophic cardiac remodeling under chronic activation of adrenergic and angiotensinergic
signaling. In this regard, the reprograming gene or cell based therapies aimed at cardiac specifc restoration or enhancement of α2-AR signaling may represent future therapeutic directions for prevention or treatment of heart failure. |
| Ключевые слова |
working myocardiocytes, alpha2-adrenoreceptor |
| Название журнала |
Biophysical Reviews
|
| URL |
https://link.springer.com/article/10.1007/s12551-023-01150-w |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=290512 |
| Файлы ресурса | |
|
|
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Зефиров Тимур Львович |
ru_RU |
| dc.contributor.author |
Зиятдинова Нафиса Ильгизовна |
ru_RU |
| dc.contributor.author |
Крылова Алевтина Васильевна |
ru_RU |
| dc.contributor.author |
Зефиров Андрей Львович |
ru_RU |
| dc.contributor.author |
Леонова Алина Маратовна |
ru_RU |
| dc.date.accessioned |
2023-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2023-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2023 |
ru_RU |
| dc.identifier.citation |
Galieva A.M. Electrical activity of rat working myocardiocytes during alpha2-adrenoreceptor stimulation / A.M. Galieva, Zefrov A.L., Ziyatdinova N.I., Krylova A.V., Zefirov T.L. // Biophysical Reviews. - 2023. - Vol. 15. - p. 1502 |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=290512 |
ru_RU |
| dc.description.abstract |
Biophysical Reviews |
ru_RU |
| dc.description.abstract |
It is known that isolated rat myocardium contains beta1-adrenoreceptors, beta2-adrenoreceptors, beta3-adrenoreceptors, beta4-adrenoreceptors, as well as alpha1-adrenoreceptors and alpha2-adrenoreceptors.
Research indicate that α2-AR isoforms (α2А-, α2B- and α2C) are expressed in cardiac myocytes with the potential to safeguard cardiac muscle under adrenergic surge by governing intracellular Ca2+
handling and contractility. By adjusting the balance between protein kinase and phosphatase activities, sarcolemmal α2-ARs are capable of counterbalancing signaling cascades that provoke hypertrophic cardiac remodeling under chronic activation of adrenergic and angiotensinergic
signaling. In this regard, the reprograming gene or cell based therapies aimed at cardiac specifc restoration or enhancement of α2-AR signaling may represent future therapeutic directions for prevention or treatment of heart failure. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
working myocardiocytes |
ru_RU |
| dc.subject |
alpha2-adrenoreceptor |
ru_RU |
| dc.title |
Electrical activity of rat working myocardiocytes during alpha2-adrenoreceptor stimulation |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
|
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