| Форма представления | Статьи в российских журналах и сборниках |
| Год публикации | 2023 |
| Язык | русский |
|
Зефиров Тимур Львович, автор
Зиятдинова Нафиса Ильгизовна, автор
Искаков Никита Георгиевич, автор
|
|
Зефиров Андрей Львович, автор
|
|
Леонова Алина Маратовна, автор
|
| Библиографическое описание на языке оригинала |
Galieva A.M. Participation of alpha2-adrenoreceptors in the regulation of bioelectrical parameters of newborn rat atrial cardiomyocytes /A.M. Galieva, N.I. Ziyatdinova, A.L. Zefrov ,N.G. Iskakov, T.L. Zefrov // Biophysical Reviews. - 2023. - Vol. 15. - p. 1515-1516. |
| Аннотация |
Adrenergic receptors, also called adrenoceptors, are proteins composed of 400 to 600 aminoacids, with seven membrane-spanning domains, and belong to the superfamily of G protein-coupled receptors (GPCR).
They are membrane receptors that activate G proteins following the binding of a ligand, thus causing a change in the cell membrane permeability to one or more ions and/or activating an enzyme attached to the receptor. Gs and Gi proteins activate and inhibit the enzyme adenylylcyclase respectively, while Gq proteins activate phospholipase C.
According to a number of authors, in rat ventricular and guinea pig and human atrial myocardium, activation of alpha2-adrenoreceptors leads to Gi-protein activation, which decreases adenylate cyclase activity, cAMP level, and thus protein kinase A activity, which eventually blocks norepinephrine exocytosis. Furthermore, it is not excluded that
the Gq protein-protein kinase C pathway is also involved in this process. it is believed that alpha2-adrenoceptor subtypes (a-, c-, and c-) are associated with Gi protein, i.e., they implement a single signaling system. |
| Ключевые слова |
alpha2-adrenoreceptors, bioelectrical parameters, newborn rat, atrial cardiomyocytes |
| Название журнала |
Biophysical Reviews
|
| URL |
https://link.springer.com/article/10.1007/s12551-023-01150-w |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=290515 |
| Файлы ресурса | |
|
|
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Зефиров Тимур Львович |
ru_RU |
| dc.contributor.author |
Зиятдинова Нафиса Ильгизовна |
ru_RU |
| dc.contributor.author |
Искаков Никита Георгиевич |
ru_RU |
| dc.contributor.author |
Зефиров Андрей Львович |
ru_RU |
| dc.contributor.author |
Леонова Алина Маратовна |
ru_RU |
| dc.date.accessioned |
2023-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2023-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2023 |
ru_RU |
| dc.identifier.citation |
Galieva A.M. Participation of alpha2-adrenoreceptors in the regulation of bioelectrical parameters of newborn rat atrial cardiomyocytes /A.M. Galieva, N.I. Ziyatdinova, A.L. Zefrov ,N.G. Iskakov, T.L. Zefrov // Biophysical Reviews. - 2023. - Vol. 15. - p. 1515-1516. |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=290515 |
ru_RU |
| dc.description.abstract |
Biophysical Reviews |
ru_RU |
| dc.description.abstract |
Adrenergic receptors, also called adrenoceptors, are proteins composed of 400 to 600 aminoacids, with seven membrane-spanning domains, and belong to the superfamily of G protein-coupled receptors (GPCR).
They are membrane receptors that activate G proteins following the binding of a ligand, thus causing a change in the cell membrane permeability to one or more ions and/or activating an enzyme attached to the receptor. Gs and Gi proteins activate and inhibit the enzyme adenylylcyclase respectively, while Gq proteins activate phospholipase C.
According to a number of authors, in rat ventricular and guinea pig and human atrial myocardium, activation of alpha2-adrenoreceptors leads to Gi-protein activation, which decreases adenylate cyclase activity, cAMP level, and thus protein kinase A activity, which eventually blocks norepinephrine exocytosis. Furthermore, it is not excluded that
the Gq protein-protein kinase C pathway is also involved in this process. it is believed that alpha2-adrenoceptor subtypes (a-, c-, and c-) are associated with Gi protein, i.e., they implement a single signaling system. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
alpha2-adrenoreceptors |
ru_RU |
| dc.subject |
bioelectrical parameters |
ru_RU |
| dc.subject |
newborn rat |
ru_RU |
| dc.subject |
atrial cardiomyocytes |
ru_RU |
| dc.title |
Participation of alpha2-adrenoreceptors in the regulation of bioelectrical parameters of newborn rat atrial cardiomyocytes |
ru_RU |
| dc.type |
Статьи в российских журналах и сборниках |
ru_RU |
|
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