| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2023 |
| Язык | английский |
|
Аймалетдинов Александр Маазович, автор
Александрова Наталья Михайловна, автор
Закирова Елена Юрьевна, автор
Маланьева Альбина Геннадьевна, автор
Ризванов Альберт Анатольевич, автор
|
| Библиографическое описание на языке оригинала |
Aleksandrova, N.M., Aimaletdinov, A.M., Malanyeva, A.G. et al. Features of Induction of In Vitro Osteodifferentiation of Adipose-Derived Mesenchymal / Aleksandrova, N.M., Aimaletdinov, A.M., Malanyeva, A.G., Rizvanov A.A., Zakirova E.Yu. // Stem Cells. Appl Biochem Microbiol. - 2023. - №59. - р. 1071–1077.
|
| Аннотация |
Appl Biochem Microbiol |
| Ключевые слова |
Мesenchymal stem cells, osteodifferentiation, bone morphogenetic protein. |
| Название журнала |
Appl Biochem Microbiol
|
| URL |
https://link.springer.com/article/10.1134/S0003683823080021#citeas |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=293164 |
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Аймалетдинов Александр Маазович |
ru_RU |
| dc.contributor.author |
Александрова Наталья Михайловна |
ru_RU |
| dc.contributor.author |
Закирова Елена Юрьевна |
ru_RU |
| dc.contributor.author |
Маланьева Альбина Геннадьевна |
ru_RU |
| dc.contributor.author |
Ризванов Альберт Анатольевич |
ru_RU |
| dc.date.accessioned |
2023-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2023-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2023 |
ru_RU |
| dc.identifier.citation |
Aleksandrova, N.M., Aimaletdinov, A.M., Malanyeva, A.G. et al. Features of Induction of In Vitro Osteodifferentiation of Adipose-Derived Mesenchymal / Aleksandrova, N.M., Aimaletdinov, A.M., Malanyeva, A.G., Rizvanov A.A., Zakirova E.Yu. // Stem Cells. Appl Biochem Microbiol. - 2023. - №59. - р. 1071–1077.
|
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=293164 |
ru_RU |
| dc.description.abstract |
Appl Biochem Microbiol |
ru_RU |
| dc.description.abstract |
The features of osteogenic differentiation of mesenchymal stem cells (MSCs) of dogs, native and genetically modified, have been compared when cultivated in different media. It was shown that calcium deposition into the extracellular matrix occurred within 21 day of cultivation of MSCs on a commercial induction medium. The use of α-MEM-based medium, which contains osteoinducing components, also caused osteogenic differentiation of MSCs, but calcium deposition was less active. Gene modification of canine MSCs with a plasmid carrying the gene for canine (Canis familiaris) bone morphogenetic protein 2 gene (BMP2) stimulated the release of alkaline phosphatase by cells, but not calcium deposition. Consequently, the formation of osteocytes from MSCs depends not only on endogenous, but also exogenous factors, which include dexamethasone in combination with ascorbic acid and β-glycerophosphate, and full osteogenic differentiation of MSCs in vitro requires many osteoinductive factors. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
Мesenchymal stem cells |
ru_RU |
| dc.subject |
osteodifferentiation |
ru_RU |
| dc.subject |
bone morphogenetic protein. |
ru_RU |
| dc.title |
Features of Induction of In Vitro Osteodifferentiation of Adipose-Derived Mesenchymal Stem Cells |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
|
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