КФУ. Карточка публикации. Solid-State Preparation of Inclusion Compounds of Native Cyclodextrins with Diclofenac Sodium

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SOLID-STATE PREPARATION OF INCLUSION COMPOUNDS OF NATIVE CYCLODEXTRINS WITH DICLOFENAC SODIUM

Форма представления

Статьи в российских журналах и сборниках

Год публикации

2024

Язык

английский

Авторы, сотрудники КФУ

Гатиатулин Аскар Камилевич, автор

Горбачук Валерий Виленович, автор

Зиганшин Марат Ахмедович, автор

Климовицкий Александр Евгеньевич, автор

Библиографическое описание на языке оригинала

Gatiatulin, A.K., Klimovitskii, A.E., Ziganshin, M.A. and Gorbatchuk, V.V. Solid-State Preparation of Inclusion Compounds of Native Cyclodextrins with Diclofenac Sodium. Russ J Gen Chem 94, 1967–1971 (2024). https://doi.org/10.1134/S1070363224080097

Аннотация

Inclusion compounds of diclofenac sodium, a non-steroidal anti-inflammatory drug, with native α-, β- and γ-cyclodextrins at varying levels of hydration were prepared by co-grinding in a ball mill. Using TG/DSC analysis, powder X-ray diffraction and solid-state IR spectroscopy, it was shown that when equimolar mixtures of native cyclodextrin and diclofenac are milled, complete inclusion of this pharmaceutical ingredient occurs, regardless of cyclodextrin hydration. The absence of water-guest competition in the solid-state inclusion process is explained by high affinity of diclofenac sodium to cyclodextrins. The prepared complexes have a significantly lower thermal stability than the separate native cyclodextrins and diclofenac sodium.

Ключевые слова

cyclodextrin, diclofenac, inclusion compound, encapsulation

Название журнала

Russian Journal of General Chemistry

URL

https://link.springer.com/article/10.1134/S1070363224080097

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https://repository.kpfu.ru/?p_id=304984

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Гатиатулин Аскар Камилевич	ru_RU
dc.contributor.author	Горбачук Валерий Виленович	ru_RU
dc.contributor.author	Зиганшин Марат Ахмедович	ru_RU
dc.contributor.author	Климовицкий Александр Евгеньевич	ru_RU
dc.date.accessioned	2024-01-01T00:00:00Z	ru_RU
dc.date.available	2024-01-01T00:00:00Z	ru_RU
dc.date.issued	2024	ru_RU
dc.identifier.citation	Gatiatulin, A.K., Klimovitskii, A.E., Ziganshin, M.A. and Gorbatchuk, V.V. Solid-State Preparation of Inclusion Compounds of Native Cyclodextrins with Diclofenac Sodium. Russ J Gen Chem 94, 1967–1971 (2024). https://doi.org/10.1134/S1070363224080097	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=304984	ru_RU
dc.description.abstract	Russian Journal of General Chemistry	ru_RU
dc.description.abstract	Inclusion compounds of diclofenac sodium, a non-steroidal anti-inflammatory drug, with native α-, β- and γ-cyclodextrins at varying levels of hydration were prepared by co-grinding in a ball mill. Using TG/DSC analysis, powder X-ray diffraction and solid-state IR spectroscopy, it was shown that when equimolar mixtures of native cyclodextrin and diclofenac are milled, complete inclusion of this pharmaceutical ingredient occurs, regardless of cyclodextrin hydration. The absence of water-guest competition in the solid-state inclusion process is explained by high affinity of diclofenac sodium to cyclodextrins. The prepared complexes have a significantly lower thermal stability than the separate native cyclodextrins and diclofenac sodium.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	cyclodextrin	ru_RU
dc.subject	diclofenac	ru_RU
dc.subject	inclusion compound	ru_RU
dc.subject	encapsulation	ru_RU
dc.title	Solid-State Preparation of Inclusion Compounds of Native Cyclodextrins with Diclofenac Sodium	ru_RU
dc.type	Статьи в российских журналах и сборниках	ru_RU