КФУ. Карточка публикации. Synthesis and selective Cu(II) complexation of lower rim substituted thiacalixarenes containing pyrazole fragments

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SYNTHESIS AND SELECTIVE CU(II) COMPLEXATION OF LOWER RIM SUBSTITUTED THIACALIXARENES CONTAINING PYRAZOLE FRAGMENTS

Форма представления

Статьи в российских журналах и сборниках

Год публикации

2024

Язык

английский

Авторы, сотрудники КФУ

Бухаров Михаил Сергеевич, автор

Исламов Даут Ринатович, автор

Калинин Валерий Игоревич, автор

Стойков Иван Иванович, автор

Шибаева Ксения Сергеевна, автор

Другие авторы

Бабаева Ольга , автор

Авторы, студенты КФУ

Расперетихина Екатерина Валерьевна, автор

Библиографическое описание на языке оригинала

Kalinin V. Synthesis and selective Cu(II) complexation of lower rim substituted thiacalixarenes containing pyrazole fragments / V. Kalinin, E. Rasperetikhina, M. Bukharov, K. Shibaeva, D. Islamov, O. Babaeva, I. Stoikov // Chimica Techno Acta. - 2024. - V.11(4). - 202411418.

Аннотация

Selective sensors for the detection and quantification of Cu(II) ions are actively used to investigate in vivo conditions in Wilsons and Menkes diseases at the cellular level. Such sensors must have a high specificity for this cation as well as low toxicity. A synthetic approach for the preparation of selective sensors for Cu(II) cations based on p-tert-butylthiacalix[4]arenes modified with 3,5-dimethylpyrazole moieties in cone, partial cone and 1,3-alternate stereoisomeric forms was developed. The obtained compounds were characterized by single-crystal XRD, NMR and IR spectroscopy, MALDI MS, and elemental analysis. All synthesized thiacalixarene compounds formed complexes with Cu(II) with the binding constants in range logK = 4.44–4.63 and 1:1 stoichiometry. The structure of the obtained complexes was studied by NMR spectroscopy and DFT methods. The obtained results can be used to develop selective Cu(II) sensors.

Ключевые слова

hiacalixarenes, pyrazoles, synthesis, copper(II) cation, sensors, selectivity.

Название журнала

Chimica Techno Acta

URL

https://chimicatechnoacta.ru/article/view/8262

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https://repository.kpfu.ru/?p_id=307058

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Бухаров Михаил Сергеевич	ru_RU
dc.contributor.author	Исламов Даут Ринатович	ru_RU
dc.contributor.author	Калинин Валерий Игоревич	ru_RU
dc.contributor.author	Стойков Иван Иванович	ru_RU
dc.contributor.author	Шибаева Ксения Сергеевна	ru_RU
dc.contributor.author	Бабаева Ольга	ru_RU
dc.contributor.author	Расперетихина Екатерина Валерьевна	ru_RU
dc.date.accessioned	2024-01-01T00:00:00Z	ru_RU
dc.date.available	2024-01-01T00:00:00Z	ru_RU
dc.date.issued	2024	ru_RU
dc.identifier.citation	Kalinin V. Synthesis and selective Cu(II) complexation of lower rim substituted thiacalixarenes containing pyrazole fragments / V. Kalinin, E. Rasperetikhina, M. Bukharov, K. Shibaeva, D. Islamov, O. Babaeva, I. Stoikov // Chimica Techno Acta. - 2024. - V.11(4). - 202411418.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=307058	ru_RU
dc.description.abstract	Chimica Techno Acta	ru_RU
dc.description.abstract	Selective sensors for the detection and quantification of Cu(II) ions are actively used to investigate in vivo conditions in Wilsons and Menkes diseases at the cellular level. Such sensors must have a high specificity for this cation as well as low toxicity. A synthetic approach for the preparation of selective sensors for Cu(II) cations based on p-tert-butylthiacalix[4]arenes modified with 3,5-dimethylpyrazole moieties in cone, partial cone and 1,3-alternate stereoisomeric forms was developed. The obtained compounds were characterized by single-crystal XRD, NMR and IR spectroscopy, MALDI MS, and elemental analysis. All synthesized thiacalixarene compounds formed complexes with Cu(II) with the binding constants in range logK = 4.44–4.63 and 1:1 stoichiometry. The structure of the obtained complexes was studied by NMR spectroscopy and DFT methods. The obtained results can be used to develop selective Cu(II) sensors.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	hiacalixarenes	ru_RU
dc.subject	pyrazoles	ru_RU
dc.subject	synthesis	ru_RU
dc.subject	copper(II) cation	ru_RU
dc.subject	sensors	ru_RU
dc.subject	selectivity.	ru_RU
dc.title	Synthesis and selective Cu(II) complexation of lower rim substituted thiacalixarenes containing pyrazole fragments	ru_RU
dc.type	Статьи в российских журналах и сборниках	ru_RU