| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2022 |
| Язык | русский |
|
Даминова Амина Галеевна, автор
|
| Библиографическое описание на языке оригинала |
Akhmadeev B. S. Temperature-sensitive emission of dialkylaminostyrylhetarene dyes and their incorporation into phospholipid aggregates: applicability for thermal sensing and cellular uptake behavior / B. S. Akhmadeev, T. P. Gerasimova, A. R. Gilfanova, S. A. Katsyuba, L. N. Islamova, G. M. Fazleeva, A. A. Kalinin, A. G. Daminova, S. V. Fedosimova, S .K. Amerhanova, A. D. Voloshina, E. G. Tanysheva, O. G. Sinyashin, A. R. Mustafina
// Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. - 2022. - V. 268, 120647 |
| Аннотация |
A series of dialkylaminostyrylhetarene dyes constructed from electron-rich and electron-deficient moieties
of various structures connected via vinylene p-bridges are introduced as temperature-sensitive luminophores. The temperature dependent emission of the dyes in the acidified dichloromethane solutions derives
from temperature-induced shift of the equilibrium between neutral and protonated forms of the dyes. The heating-induced blue shift and intensification of emission of neutral form of the dyes make them a promising basis for development of nanoparticles exhibiting temperature-sensitivity in aqueous solutions at pH
typical of biological liquids. Hydrophobicity-driven incorporation of the water insoluble dyes into L-a-phos phatidylcholine(PC)-based bilayers allows to obtain water dispersible dye-PC aggregates, and to follow their emission in the aqueous solutions. Structure of the dyes has strong impact on the efficacy of the dyes incorporation into the PC-based bilayers, temperature sensitivity of emission of the dye-PC aggregates and its reversibility under the heating/cooling cycles. This enables structural optimization of the dyes in order to obtain the dye-PC species demonstrating maximal temperature dependence and reversibility of their luminescence in aqueous solutions. The selected leader exhibits low cytotoxicity exemplified for MHeLa and Chang Liver cell lines, while the efficient cell internalization of the dye, manifested in the staining of the cell cytoplasm, opens further opportunities for biosensing applications. |
| Ключевые слова |
Dye, Structure?property relationship, Phospholipid bilayer,Cellular marking,Temperature sensitive luminescence |
| Название журнала |
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
|
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=310723 |
| Файлы ресурса | |
|
|
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Даминова Амина Галеевна |
ru_RU |
| dc.date.accessioned |
2022-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2022-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2022 |
ru_RU |
| dc.identifier.citation |
Akhmadeev B. S. Temperature-sensitive emission of dialkylaminostyrylhetarene dyes and their incorporation into phospholipid aggregates: applicability for thermal sensing and cellular uptake behavior / B. S. Akhmadeev, T. P. Gerasimova, A. R. Gilfanova, S. A. Katsyuba, L. N. Islamova, G. M. Fazleeva, A. A. Kalinin, A. G. Daminova, S. V. Fedosimova, S .K. Amerhanova, A. D. Voloshina, E. G. Tanysheva, O. G. Sinyashin, A. R. Mustafina
// Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. - 2022. - V. 268, 120647 |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=310723 |
ru_RU |
| dc.description.abstract |
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy |
ru_RU |
| dc.description.abstract |
A series of dialkylaminostyrylhetarene dyes constructed from electron-rich and electron-deficient moieties
of various structures connected via vinylene p-bridges are introduced as temperature-sensitive luminophores. The temperature dependent emission of the dyes in the acidified dichloromethane solutions derives
from temperature-induced shift of the equilibrium between neutral and protonated forms of the dyes. The heating-induced blue shift and intensification of emission of neutral form of the dyes make them a promising basis for development of nanoparticles exhibiting temperature-sensitivity in aqueous solutions at pH
typical of biological liquids. Hydrophobicity-driven incorporation of the water insoluble dyes into L-a-phos phatidylcholine(PC)-based bilayers allows to obtain water dispersible dye-PC aggregates, and to follow their emission in the aqueous solutions. Structure of the dyes has strong impact on the efficacy of the dyes incorporation into the PC-based bilayers, temperature sensitivity of emission of the dye-PC aggregates and its reversibility under the heating/cooling cycles. This enables structural optimization of the dyes in order to obtain the dye-PC species demonstrating maximal temperature dependence and reversibility of their luminescence in aqueous solutions. The selected leader exhibits low cytotoxicity exemplified for MHeLa and Chang Liver cell lines, while the efficient cell internalization of the dye, manifested in the staining of the cell cytoplasm, opens further opportunities for biosensing applications. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
Dye |
ru_RU |
| dc.subject |
Structure?property relationship |
ru_RU |
| dc.subject |
Phospholipid bilayer |
ru_RU |
| dc.subject |
Cellular marking |
ru_RU |
| dc.subject |
Temperature sensitive luminescence |
ru_RU |
| dc.title |
Temperature-sensitive emission of dialkylaminostyrylhetarene dyes and
their incorporation into phospholipid aggregates: Applicability for
thermal sensing and cellular uptake behavior |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
|
EN 
中文 
ES 
Карта сайта
