| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2024 |
|
Гомзикова Марина Олеговна, автор
Квон Анна Игоревна, автор
Старостина Ирина Георгиевна, автор
Сыромятникова Валерия Юрьевна, автор
|
|
Квон Анна Игоревна, автор
|
| Библиографическое описание на языке оригинала |
Syromiatnikova, V.Y., Kvon, A.I., Starostina, I.G. et al. Strategies to enhance the efficacy of FGF2-based therapies for skin wound healing. Arch Dermatol Res 316, 405 (2024). https://doi.org/10.1007/s00403-024-02953-x. |
| Аннотация |
Archives of Dermatological Research |
| Ключевые слова |
Basic fibroblast growth factor, skin regeneration, wound healing. |
| Название журнала |
Archives of Dermatological Research
|
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=311566 |
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Гомзикова Марина Олеговна |
ru_RU |
| dc.contributor.author |
Квон Анна Игоревна |
ru_RU |
| dc.contributor.author |
Старостина Ирина Георгиевна |
ru_RU |
| dc.contributor.author |
Сыромятникова Валерия Юрьевна |
ru_RU |
| dc.contributor.author |
Квон Анна Игоревна |
ru_RU |
| dc.date.accessioned |
2024-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2024-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2024 |
ru_RU |
| dc.identifier.citation |
Syromiatnikova, V.Y., Kvon, A.I., Starostina, I.G. et al. Strategies to enhance the efficacy of FGF2-based therapies for skin wound healing. Arch Dermatol Res 316, 405 (2024). https://doi.org/10.1007/s00403-024-02953-x. |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=311566 |
ru_RU |
| dc.description.abstract |
Archives of Dermatological Research |
ru_RU |
| dc.description.abstract |
Basic fibroblast growth factor (FGF2 or bFGF) is critical for optimal wound healing. Experimental studies show that local application of FGF2 is a promising therapeutic approach to stimulate tissue regeneration, including for the treatment of chronic wounds that have a low healing potential or are characterised by a pathologically altered healing process. However, the problem of low efficiency of growth factors application due to their rapid loss of biological activity in the aggressive proteolytic environment of the wound remains. Therefore, ways to preserve the efficacy of FGF2 for wound treatment are being actively developed. This review considers the following strategies to improve the effectiveness of FGF2-based therapy: (1) use of vehicles/carriers for delivery and gradual release of FGF2; (2) chemical modification of FGF2 to increase the stability of the molecule; (3) use of genetic constructs encoding FGF2 for de novo synthesis of protein in the wound. In addition, this review |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
Basic fibroblast growth factor |
ru_RU |
| dc.subject |
skin regeneration |
ru_RU |
| dc.subject |
wound healing. |
ru_RU |
| dc.title |
Strategies to enhance the efficacy of FGF2-based therapies for skin wound healing |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
|
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