| Форма представления | Статьи в российских журналах и сборниках |
| Год публикации | 2025 |
|
Ананьев Антон Сергеевич, автор
Гилиждинова Карина Раулевна, автор
Нурмиева Динара Альбертовна, автор
Ситдикова Гузель Фаритовна, автор
|
| Другие авторы |
Петров Алексей Михайлович |
|
Ананьев Антон Сергеевич, автор
Гилиждинова Карина Раулевна, автор
Нурмиева Динара Альбертовна, автор
|
| Библиографическое описание на языке оригинала |
Gilizhdinova, K. R., Nurmieva, D. A., Ananev, A. S., Petrov, A. M., & Sitdikova, G. F. (2025). Effects of 24-Hydroxycholesterol on the ATP-Induced Trigeminal Nerve Electrical Activity and the Mast Cells Degranulation. Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology, 19(1), 52-59. |
| Аннотация |
The trigeminovascular system plays a pivotal role in the generation of nociceptive activity, which
underlies pain in migraine and includes trigeminal nerve afferents, dura mater vessels, and mast cells. Adenosine
triphosphate (ATP) is one of the main mediators of the interaction between vessels, nerve endings, and mast
cells. ATP activates P2X3 receptors of trigeminal nerve afferents and P2X7 receptors of mast cells. 24-Hydroxy
cholesterol is the primary brain cholesterol metabolite synthesized by neurons and is capable of freely entering
the bloodstream by crossing the blood?brain barrier. The purpose of this study was to examine the impact of
24-hydroxycholesterol on the electrical activity of trigeminal nerve afferents triggered by ATP application and
on the mast cells degranulation in rat brain meninges. The electrical activity of the trigeminal nerve was
recorded using an extracellular electrode in a rat hemiskull preparation, mast cells were stained with toluidine
blue. 2 |
| Ключевые слова |
ATP, 24-hydroxycholesterol, trigeminal nerve afferents, meninges, mast cells |
| Место издания |
Москва |
| Название журнала |
Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology
|
| Издательство |
Pleiades Publishing |
| URL |
https://link.springer.com/article/10.1134/S1990747824700454 |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=314629 |
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Ананьев Антон Сергеевич |
ru_RU |
| dc.contributor.author |
Гилиждинова Карина Раулевна |
ru_RU |
| dc.contributor.author |
Нурмиева Динара Альбертовна |
ru_RU |
| dc.contributor.author |
Ситдикова Гузель Фаритовна |
ru_RU |
| dc.contributor.author |
Ананьев Антон Сергеевич |
ru_RU |
| dc.contributor.author |
Гилиждинова Карина Раулевна |
ru_RU |
| dc.contributor.author |
Нурмиева Динара Альбертовна |
ru_RU |
| dc.date.accessioned |
2025-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2025-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2025 |
ru_RU |
| dc.identifier.citation |
Gilizhdinova, K. R., Nurmieva, D. A., Ananev, A. S., Petrov, A. M., & Sitdikova, G. F. (2025). Effects of 24-Hydroxycholesterol on the ATP-Induced Trigeminal Nerve Electrical Activity and the Mast Cells Degranulation. Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology, 19(1), 52-59. |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=314629 |
ru_RU |
| dc.description.abstract |
Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology |
ru_RU |
| dc.description.abstract |
The trigeminovascular system plays a pivotal role in the generation of nociceptive activity, which
underlies pain in migraine and includes trigeminal nerve afferents, dura mater vessels, and mast cells. Adenosine
triphosphate (ATP) is one of the main mediators of the interaction between vessels, nerve endings, and mast
cells. ATP activates P2X3 receptors of trigeminal nerve afferents and P2X7 receptors of mast cells. 24-Hydroxy
cholesterol is the primary brain cholesterol metabolite synthesized by neurons and is capable of freely entering
the bloodstream by crossing the blood?brain barrier. The purpose of this study was to examine the impact of
24-hydroxycholesterol on the electrical activity of trigeminal nerve afferents triggered by ATP application and
on the mast cells degranulation in rat brain meninges. The electrical activity of the trigeminal nerve was
recorded using an extracellular electrode in a rat hemiskull preparation, mast cells were stained with toluidine
blue. 2 |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.publisher |
Pleiades Publishing |
ru_RU |
| dc.subject |
ATP |
ru_RU |
| dc.subject |
24-hydroxycholesterol |
ru_RU |
| dc.subject |
trigeminal nerve afferents |
ru_RU |
| dc.subject |
meninges |
ru_RU |
| dc.subject |
mast cells |
ru_RU |
| dc.title |
Effects of 24-Hydroxycholesterol on the ATP-Induced Trigeminal
Nerve Electrical Activity and the Mast Cells Degranulation |
ru_RU |
| dc.type |
Статьи в российских журналах и сборниках |
ru_RU |
|
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