КФУ. Карточка публикации. Neuroimplants and the Glial Scar: What Makes theBrain

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ФЕДЕРАЛЬНЫЙ УНИВЕРСИТЕТ

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NEUROIMPLANTS AND THE GLIAL SCAR: WHAT MAKES THEBRAIN&NDASH;COMPUTER LINK WORK?

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2025

Язык

английский

Авторы, сотрудники КФУ

Аганов Альберт Вартанович, автор

Егорчев Антон Александрович, автор

Мельникова Анастасия Александровна, автор

Павельев Михаил Николаевич, автор

Другие авторы

Парпура Владимир , автор

Библиографическое описание на языке оригинала

Paveliev, M., Melnikova A., Egorchev A. A., Parpura V., Aganov A.V. “ Neuroimplants and the Glial Scar: What Makes the Brain–Computer Link Work?.” Journal of Neurochemistry 2025, 169, no. 9: e70203. https://doi.org/10.1111/jnc.70203

Аннотация

Neuroimplants are likely major technological breakthroughs of the next decade with the potential for unprecedented social im-pact. In addition to attractive and miracle-looking possibilities, the major obstacle for the industry is complicated, unpredictable,and unfavorable side effects due to tissue damage, biocompatibility limitations, and foreign body response at the brain–implantinterface. Luckily, one major barrier preventing the connection of the neuroimplant to brain cells—the glial scar—has been stud-ied previously for its role in brain trauma. This review highlights pharmacological and tissue engineering avenues that could bereadily transferred from the brain trauma area to fast-growing neuroimplant engineering. The opportunities for chondroitinaseABC treatment, stem cells, and hydrogels for the prevention of glial scarring are emphasized. Alternatively, the glial scar mayalso be viewed not as an obstacle but as a possible regeneration-permissive component of the optimally working brain–neuro-implant interface. Feasible steps in that direction are discussed, including applications for chondroitin sulfate-binding peptides.Finally, the crucial role of new microscopy and data processing techniques for peri-implant glial scar monitoring is highlighted.To that end, we stress the importance of artificial intelligence, including artificial neuronal networks, for the analysis of cellmorphology at the brain–neuroimplant interface.

Ключевые слова

brain injury, brain?computer interface, glial scar, microelectrode array, spinal cord injury, stem cells

Название журнала

Journal of Neurochemistry

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https://repository.kpfu.ru/?p_id=317095

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Аганов Альберт Вартанович	ru_RU
dc.contributor.author	Егорчев Антон Александрович	ru_RU
dc.contributor.author	Мельникова Анастасия Александровна	ru_RU
dc.contributor.author	Павельев Михаил Николаевич	ru_RU
dc.contributor.author	Парпура Владимир	ru_RU
dc.date.accessioned	2025-01-01T00:00:00Z	ru_RU
dc.date.available	2025-01-01T00:00:00Z	ru_RU
dc.date.issued	2025	ru_RU
dc.identifier.citation	Paveliev, M., Melnikova A., Egorchev A. A., Parpura V., Aganov A.V. “ Neuroimplants and the Glial Scar: What Makes the Brain–Computer Link Work?.” Journal of Neurochemistry 2025, 169, no. 9: e70203. https://doi.org/10.1111/jnc.70203	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=317095	ru_RU
dc.description.abstract	Journal of Neurochemistry	ru_RU
dc.description.abstract	Neuroimplants are likely major technological breakthroughs of the next decade with the potential for unprecedented social im-pact. In addition to attractive and miracle-looking possibilities, the major obstacle for the industry is complicated, unpredictable,and unfavorable side effects due to tissue damage, biocompatibility limitations, and foreign body response at the brain–implantinterface. Luckily, one major barrier preventing the connection of the neuroimplant to brain cells—the glial scar—has been stud-ied previously for its role in brain trauma. This review highlights pharmacological and tissue engineering avenues that could bereadily transferred from the brain trauma area to fast-growing neuroimplant engineering. The opportunities for chondroitinaseABC treatment, stem cells, and hydrogels for the prevention of glial scarring are emphasized. Alternatively, the glial scar mayalso be viewed not as an obstacle but as a possible regeneration-permissive component of the optimally working brain–neuro-implant interface. Feasible steps in that direction are discussed, including applications for chondroitin sulfate-binding peptides.Finally, the crucial role of new microscopy and data processing techniques for peri-implant glial scar monitoring is highlighted.To that end, we stress the importance of artificial intelligence, including artificial neuronal networks, for the analysis of cellmorphology at the brain–neuroimplant interface.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	brain injury	ru_RU
dc.subject	brain?computer interface	ru_RU
dc.subject	glial scar	ru_RU
dc.subject	microelectrode array	ru_RU
dc.subject	spinal cord injury	ru_RU
dc.subject	stem cells	ru_RU
dc.title	Neuroimplants and the Glial Scar: What Makes theBrain–Computer Link Work?	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU