| Форма представления | Статьи в российских журналах и сборниках |
| Год публикации | 2025 |
| Язык | русский |
|
Биктемирова Раиса Габдулловна, автор
Зефиров Тимур Львович, автор
Зиятдинова Нафиса Ильгизовна, автор
Купцова Анна Михайловна, автор
|
|
Шаймарданова Гульнара Фердинантовна, автор
|
| Библиографическое описание на языке оригинала |
Kuptsova A.M. Old Rats' Isolated Heart Reaction Upon Stimulation of Alpha2-Adrenergic Receptors / A.M. Kuptsova / N.I. Ziyatdinova / G.F. Shaimardanova / R.G. Biktemirova / T.L. Zefirov // Opera Med Physiol. 2025. - Vol. 12 (3). - р. 108-114 |
| Аннотация |
Aging is a natural and inevitable process that worsens the quality of life and shortens its duration. In the process of aging, the cardiovascular system undergoes significant restructuring, diastolic dysfunction is observed, vascular stiffness increases and vasodilation decreases. α2-ARs are widely distributed in the body and are involved in the regulation of heart and vascular functions. In pathological conditions, there is an increase in the expression of α2-AR subtypes, a violation of their functions, and a decrease in the effectiveness of the associated signalling cascades. The study aimed to investigate the effect of the α2-AR agonist clonidine hydrochloride at concentrations of 10-9-10-6 M on the inotropy, chronotropy and coronary flow of the old rats isolated heart. α2-AR stimulation changes all the studied parameters of the old rats isolated heart. The force of left the ventricular myocardium contraction decreases at concentrations of 10-9 and 10-8 M, and increases at concentrations of 10-7 and 10-6 M. The α2-AR agonist causes a decrease in heart rate in all studied concentrations. Stimulation of α2-AR in lower concentrations (10-9 - 10-7 M) reduces coronary flow, and the maximum concentration of clonidine hydrochloride (10-6 M) increases. |
| Ключевые слова |
α2-adrenergic receptorschronotropyinotropycoronary flowisolated heartrat |
| Название журнала |
Opera Medica et Physiologica
|
| URL |
https://operamedphys.org/content/old-rats%E2%80%99-isolated-heart-reaction-upon-stimulation-alpha2-adrenergic-receptors |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=317352 |
| Файлы ресурса | |
|
|
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Биктемирова Раиса Габдулловна |
ru_RU |
| dc.contributor.author |
Зефиров Тимур Львович |
ru_RU |
| dc.contributor.author |
Зиятдинова Нафиса Ильгизовна |
ru_RU |
| dc.contributor.author |
Купцова Анна Михайловна |
ru_RU |
| dc.contributor.author |
Шаймарданова Гульнара Фердинантовна |
ru_RU |
| dc.date.accessioned |
2025-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2025-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2025 |
ru_RU |
| dc.identifier.citation |
Kuptsova A.M. Old Rats' Isolated Heart Reaction Upon Stimulation of Alpha2-Adrenergic Receptors / A.M. Kuptsova / N.I. Ziyatdinova / G.F. Shaimardanova / R.G. Biktemirova / T.L. Zefirov // Opera Med Physiol. 2025. - Vol. 12 (3). - р. 108-114 |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=317352 |
ru_RU |
| dc.description.abstract |
Opera Medica et Physiologica |
ru_RU |
| dc.description.abstract |
Aging is a natural and inevitable process that worsens the quality of life and shortens its duration. In the process of aging, the cardiovascular system undergoes significant restructuring, diastolic dysfunction is observed, vascular stiffness increases and vasodilation decreases. α2-ARs are widely distributed in the body and are involved in the regulation of heart and vascular functions. In pathological conditions, there is an increase in the expression of α2-AR subtypes, a violation of their functions, and a decrease in the effectiveness of the associated signalling cascades. The study aimed to investigate the effect of the α2-AR agonist clonidine hydrochloride at concentrations of 10-9-10-6 M on the inotropy, chronotropy and coronary flow of the old rats isolated heart. α2-AR stimulation changes all the studied parameters of the old rats isolated heart. The force of left the ventricular myocardium contraction decreases at concentrations of 10-9 and 10-8 M, and increases at concentrations of 10-7 and 10-6 M. The α2-AR agonist causes a decrease in heart rate in all studied concentrations. Stimulation of α2-AR in lower concentrations (10-9 - 10-7 M) reduces coronary flow, and the maximum concentration of clonidine hydrochloride (10-6 M) increases. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
|
ru_RU |
| dc.title |
Old Rats' Isolated Heart Reaction Upon Stimulation of Alpha2-Adrenergic Receptors |
ru_RU |
| dc.type |
Статьи в российских журналах и сборниках |
ru_RU |
|
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