КФУ. Карточка публикации. Ammonium catecholaldehydes as multifunctional bioactive agents: Evaluating antimicrobial, antioxidant, and antiplatelet activity

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AMMONIUM CATECHOLALDEHYDES AS MULTIFUNCTIONAL BIOACTIVE AGENTS: EVALUATING ANTIMICROBIAL, ANTIOXIDANT, AND ANTIPLATELET ACTIVITY

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2025

Язык

английский

Авторы, сотрудники КФУ

Богданов Андрей Владимирович, автор

Зиятдинова Гузель Камилевна, автор

Другие авторы

Yi Wang , автор

Арсеньев Максим , автор

Бухаров Сергей , автор

Волошина Александра , автор

Жиганшина Эльнара , автор

Кузовлев Артем , автор

Любина Анна , автор

Самородов Александра , автор

Тагашева Роза , автор

Цивилева Ольга , автор

Библиографическое описание на языке оригинала

Bogdanov, A.V. Ammonium catecholaldehydes as multifunctional bioactive agents: Evaluating antimicrobial, antioxidant, and antiplatelet activity / A.V. Bogdanov, R.G. Tagasheva, A. Voloshina, A. Lyubina, O. Tsivileva, A.N. Kuzovlev, W. Yi, A.V. Samorodov, G.K. Ziyatdinova, E.R. Zhiganshina, M.V. Arsenyev, S.V. Bukharov // Int. J. Mol. Sci. – 2025. – V. 26. – № 16. – Art. 7866.

Аннотация

A wide range of water-soluble quaternary ammonium acylhydrazones based on catecholaldehyde were synthesized and characterized using NMR, IR spectroscopy, and elemental analysis. The total antioxidant capacity of the acylhydrazones discussed herein was estimated via coulometric titration with electrogenerated bromine. Pyridinium derivatives 11a–e exhibited the highest antioxidant capacity. Quaternary ammonium acylhydrazones demonstrated high antimicrobial activity against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus strains. Furthermore, low hemo- and cytotoxicity and the absence of a negative effect on the hemostatic system were confirmed for the studied compounds. According to the results of a CV test, the antimicrobial effect of the most active acylhydrazones, namely, 9a, 10b, 10c, and 11a, is associated with the destruction of the bacterial cell wall. High or moderate activity against phytopathogens of bacterial origin was observed for all the acylhydrazones evaluated. Anti-aggregation activity was observed for compound 10b; the extent was 1.6-fold greater than that exhibited by acetylsalicylic acid. On the contrary, compound 9d exhibited a pro-aggregant effect (with a 6.3% increase in platelet aggregation and a >15% decrease in the latent period compared to the control). Thus, the data obtained can be considered the basis for further pharmaceutical development of these effective drugs with antithrombotic and hemostatic potential.

Ключевые слова

Hydrazones, ammonium salts, catechols, antioxidants, phytopathogens, antimicrobial activity

Название журнала

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

URL

https://www.scopus.com/inward/record.uri?eid=2-s2.0-105014435627&doi=10.3390%2Fijms26167866&partnerID=40&md5=a2dbf0836bcfb420b54bfc3a885ec5ab

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https://repository.kpfu.ru/?p_id=317541

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Богданов Андрей Владимирович	ru_RU
dc.contributor.author	Зиятдинова Гузель Камилевна	ru_RU
dc.contributor.author	Yi Wang	ru_RU
dc.contributor.author	Арсеньев Максим	ru_RU
dc.contributor.author	Бухаров Сергей	ru_RU
dc.contributor.author	Волошина Александра	ru_RU
dc.contributor.author	Жиганшина Эльнара	ru_RU
dc.contributor.author	Кузовлев Артем	ru_RU
dc.contributor.author	Любина Анна	ru_RU
dc.contributor.author	Самородов Александра	ru_RU
dc.contributor.author	Тагашева Роза	ru_RU
dc.contributor.author	Цивилева Ольга	ru_RU
dc.date.accessioned	2025-01-01T00:00:00Z	ru_RU
dc.date.available	2025-01-01T00:00:00Z	ru_RU
dc.date.issued	2025	ru_RU
dc.identifier.citation	Bogdanov, A.V. Ammonium catecholaldehydes as multifunctional bioactive agents: Evaluating antimicrobial, antioxidant, and antiplatelet activity / A.V. Bogdanov, R.G. Tagasheva, A. Voloshina, A. Lyubina, O. Tsivileva, A.N. Kuzovlev, W. Yi, A.V. Samorodov, G.K. Ziyatdinova, E.R. Zhiganshina, M.V. Arsenyev, S.V. Bukharov // Int. J. Mol. Sci. – 2025. – V. 26. – № 16. – Art. 7866.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=317541	ru_RU
dc.description.abstract	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	ru_RU
dc.description.abstract	A wide range of water-soluble quaternary ammonium acylhydrazones based on catecholaldehyde were synthesized and characterized using NMR, IR spectroscopy, and elemental analysis. The total antioxidant capacity of the acylhydrazones discussed herein was estimated via coulometric titration with electrogenerated bromine. Pyridinium derivatives 11a–e exhibited the highest antioxidant capacity. Quaternary ammonium acylhydrazones demonstrated high antimicrobial activity against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus strains. Furthermore, low hemo- and cytotoxicity and the absence of a negative effect on the hemostatic system were confirmed for the studied compounds. According to the results of a CV test, the antimicrobial effect of the most active acylhydrazones, namely, 9a, 10b, 10c, and 11a, is associated with the destruction of the bacterial cell wall. High or moderate activity against phytopathogens of bacterial origin was observed for all the acylhydrazones evaluated. Anti-aggregation activity was observed for compound 10b; the extent was 1.6-fold greater than that exhibited by acetylsalicylic acid. On the contrary, compound 9d exhibited a pro-aggregant effect (with a 6.3% increase in platelet aggregation and a >15% decrease in the latent period compared to the control). Thus, the data obtained can be considered the basis for further pharmaceutical development of these effective drugs with antithrombotic and hemostatic potential.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Hydrazones	ru_RU
dc.subject	ammonium salts	ru_RU
dc.subject	catechols	ru_RU
dc.subject	antioxidants	ru_RU
dc.subject	phytopathogens	ru_RU
dc.subject	antimicrobial activity	ru_RU
dc.title	Ammonium catecholaldehydes as multifunctional bioactive agents: Evaluating antimicrobial, antioxidant, and antiplatelet activity	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU