| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2025 |
| Язык | английский |
|
Киясов Андрей Павлович, автор
Мельникова Анастасия Александровна, автор
Павельев Михаил Николаевич, автор
Титова Ангелина Андреевна, автор
|
| Библиографическое описание на языке оригинала |
Paveliev M. Second harmonic generation for brain imaging: pathology-related studies / M. Paveliev, A. Melnikova1, D.V. Samigullin, A.A. Egorchev, A.A. Titova, A.P. Kiyasov, I.Yu. Popova, V.Parpura, A.V. Aganov // Biophysical Reviews. – 2025. – V. ?. – 20 p. doi.org/10.1007/s12551-025-01370-2 |
| Аннотация |
Microscopy of the brain has been facing problems of contrast and thick tissue imaging. Second harmonic generation (SHG)
is a non-linear effect of the light interaction with the imaged material, resulting in photon emission at half the wavelength of
the absorbed light. SHG microscopy provides an unprecedented opportunity for imaging collagen and other noncentrosymmetric
protein fibrils in unstained thick tissue samples and in the live brain via a regular multiphoton setup. This opens a
remarkable methodological window for imaging pathological processes of high importance, including brain trauma, fibrosis,
tumorigenesis, and neuroimplant-induced foreign body response. Moreover, SHG is a valuable tool for imaging astrocytes and
nerve fiber microtubules. Third harmonic generation enhanced by three-photon resonance with the Soret band of hemoglobin
is combined with SHG to resolve the microstructure of blood vessel walls and astrocyte-process endfeet on gliovascular
interfaces. Here, we review current state-of-the-art methods in the field of brain imaging applications of SHG, including
research on brain and spinal cord injury, glioma, ischemia, Alzheimer's disease, neuroimplantation, and brain meninges. We
then address the method development perspective in the broader context of other tissue pathologies. Finally, we account for
recent progress in artificial intelligence applications for SHG microscopy data analysis. |
| Ключевые слова |
Brain imaging ? Second harmonic generation ? Collagen ? Glioma ? Brain‒computer interface ? Machine
learning |
| Название журнала |
Biophysical Reviews
|
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=318020 |
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Киясов Андрей Павлович |
ru_RU |
| dc.contributor.author |
Мельникова Анастасия Александровна |
ru_RU |
| dc.contributor.author |
Павельев Михаил Николаевич |
ru_RU |
| dc.contributor.author |
Титова Ангелина Андреевна |
ru_RU |
| dc.date.accessioned |
2025-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2025-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2025 |
ru_RU |
| dc.identifier.citation |
Paveliev M. Second harmonic generation for brain imaging: pathology-related studies / M. Paveliev, A. Melnikova1, D.V. Samigullin, A.A. Egorchev, A.A. Titova, A.P. Kiyasov, I.Yu. Popova, V.Parpura, A.V. Aganov // Biophysical Reviews. – 2025. – V. ?. – 20 p. doi.org/10.1007/s12551-025-01370-2 |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=318020 |
ru_RU |
| dc.description.abstract |
Biophysical Reviews |
ru_RU |
| dc.description.abstract |
Microscopy of the brain has been facing problems of contrast and thick tissue imaging. Second harmonic generation (SHG)
is a non-linear effect of the light interaction with the imaged material, resulting in photon emission at half the wavelength of
the absorbed light. SHG microscopy provides an unprecedented opportunity for imaging collagen and other noncentrosymmetric
protein fibrils in unstained thick tissue samples and in the live brain via a regular multiphoton setup. This opens a
remarkable methodological window for imaging pathological processes of high importance, including brain trauma, fibrosis,
tumorigenesis, and neuroimplant-induced foreign body response. Moreover, SHG is a valuable tool for imaging astrocytes and
nerve fiber microtubules. Third harmonic generation enhanced by three-photon resonance with the Soret band of hemoglobin
is combined with SHG to resolve the microstructure of blood vessel walls and astrocyte-process endfeet on gliovascular
interfaces. Here, we review current state-of-the-art methods in the field of brain imaging applications of SHG, including
research on brain and spinal cord injury, glioma, ischemia, Alzheimer's disease, neuroimplantation, and brain meninges. We
then address the method development perspective in the broader context of other tissue pathologies. Finally, we account for
recent progress in artificial intelligence applications for SHG microscopy data analysis. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
|
ru_RU |
| dc.title |
Second harmonic generation for brain imaging: pathology-related studies |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
|
EN 
中文 
ES 
Карта сайта
