КФУ. Карточка публикации. Stimulation of Alpha-2 Adrenoreceptors against the Background of Hyperpolarization-Activated Current Blockade at Different Formation Stages of Cardiac Adrenergic Innervation

RUS

- EN
- 中文
- ES

STIMULATION OF ALPHA-2 ADRENORECEPTORS AGAINST THE BACKGROUND OF HYPERPOLARIZATION-ACTIVATED CURRENT BLOCKADE AT DIFFERENT FORMATION STAGES OF CARDIAC ADRENERGIC INNERVATION

Форма представления

Статьи в российских журналах и сборниках

Год публикации

2025

Язык

русский

Авторы, сотрудники КФУ

Зефиров Тимур Львович, автор

Зиятдинова Нафиса Ильгизовна, автор

Искаков Никита Георгиевич, автор

Купцова Анна Михайловна, автор

Другие авторы

Зефиров Андрей Львович, автор

Библиографическое описание на языке оригинала

Kuptsova A.M. Stimulation of Alpha-2 Adrenoreceptors against the Background of Hyperpolarization-Activated Current Blockade at Different Formation Stages of Cardiac Adrenergic Innervation /A.M. Kuptsova, N.I. Ziyatdinova, A.L. Zefirov, N.G. Iskakov, T.L. Zefirov // Journal of Evolutionary Biochemistry and Physiology. 2025. - Vol. 61. - N. 5. - pp. 1363–1371.

Аннотация

Abstract—In different periods of postnatal development, the components of the autonomic nervous system, including specific receptors and neurotransmitters involved in the control of cardiovascular functions, are characterized by significant dynamics and variability. Although in humans and animals, α2-adrenoceptors (α2-ARs) and the hyperpolarization-activated current (If) are widespread and involved in the regulation of multiple functions, their modulatory role at different stages of the formation and development of cardiac adrenergic regulation has been insufficiently studied. The present study was carried out on isolated hearts of 1-week-old, 3-week-old, and adult white rats. Heart rate (HR) and coronary flow (CF) in the Langendorff rat heart were recorded upon α2-AR activation with clonidine hydrochloride (10–6 M) against the background of If blocker ZD7288 application at 10–9 M and 10–5 M. In 1-week-old rat pups, α2-ARs activation evoked bidirectional changes in CF depending on If blocker concentration, causing its significant increase at 10–9 M and bidirectional dynamics at 10–5 M. In 3-week-old rat pups, α2-AR stimulation reduced CF, while against the background of preliminary If blockade, the CF dynamics changed to positive. In adult rats, α2-AR activation against the background of If blockade caused a decrease in CF. The α2-AR agonist evoked bidirectional changes in HR in 1-week-old and adult rats, causing only a significant reduction in HR in 3-week-old rat pups. Stimulation of α2-ARs against the background of If blockade did not alter the HR dynamics in 3-week-old rats and abolished bidirectional HR changes in adult and 1-week-old animals, causing only a decrease in HR in adults and an increase in HR in newborns. The obtained results demonstrate that α2-adrenergic cardiac regulation is modulated by If, with the degree and direction of the effects depending on the maturity level of cardiac sympathetic innervation.

Ключевые слова

alpha-2 adrenergic receptor, hyperpolarization-activated current, isolated heart, ontogenesis, rat

Название журнала

JOURNAL OF EVOLUTIONARY BIOCHEMISTRY AND PHYSIOLOGY

URL

https://link.springer.com/article/10.1134/S0022093025050047?utm_source=rct_congratemailt&utm_medium=email&utm_campaign=nonoa_20251105&utm_content=10.1134/S0022093025050047

Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку

https://repository.kpfu.ru/?p_id=319155

Файлы ресурса

Название файла	Размер (Мб)	Формат
2025_RFZh_im._Sechenova.pdf	0,55	pdf	посмотреть / скачать

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Зефиров Тимур Львович	ru_RU
dc.contributor.author	Зиятдинова Нафиса Ильгизовна	ru_RU
dc.contributor.author	Искаков Никита Георгиевич	ru_RU
dc.contributor.author	Купцова Анна Михайловна	ru_RU
dc.contributor.author	Зефиров Андрей Львович	ru_RU
dc.date.accessioned	2025-01-01T00:00:00Z	ru_RU
dc.date.available	2025-01-01T00:00:00Z	ru_RU
dc.date.issued	2025	ru_RU
dc.identifier.citation	Kuptsova A.M. Stimulation of Alpha-2 Adrenoreceptors against the Background of Hyperpolarization-Activated Current Blockade at Different Formation Stages of Cardiac Adrenergic Innervation /A.M. Kuptsova, N.I. Ziyatdinova, A.L. Zefirov, N.G. Iskakov, T.L. Zefirov // Journal of Evolutionary Biochemistry and Physiology. 2025. - Vol. 61. - N. 5. - pp. 1363–1371.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=319155	ru_RU
dc.description.abstract	JOURNAL OF EVOLUTIONARY BIOCHEMISTRY AND PHYSIOLOGY	ru_RU
dc.description.abstract	Abstract—In different periods of postnatal development, the components of the autonomic nervous system, including specific receptors and neurotransmitters involved in the control of cardiovascular functions, are characterized by significant dynamics and variability. Although in humans and animals, α2-adrenoceptors (α2-ARs) and the hyperpolarization-activated current (If) are widespread and involved in the regulation of multiple functions, their modulatory role at different stages of the formation and development of cardiac adrenergic regulation has been insufficiently studied. The present study was carried out on isolated hearts of 1-week-old, 3-week-old, and adult white rats. Heart rate (HR) and coronary flow (CF) in the Langendorff rat heart were recorded upon α2-AR activation with clonidine hydrochloride (10–6 M) against the background of If blocker ZD7288 application at 10–9 M and 10–5 M. In 1-week-old rat pups, α2-ARs activation evoked bidirectional changes in CF depending on If blocker concentration, causing its significant increase at 10–9 M and bidirectional dynamics at 10–5 M. In 3-week-old rat pups, α2-AR stimulation reduced CF, while against the background of preliminary If blockade, the CF dynamics changed to positive. In adult rats, α2-AR activation against the background of If blockade caused a decrease in CF. The α2-AR agonist evoked bidirectional changes in HR in 1-week-old and adult rats, causing only a significant reduction in HR in 3-week-old rat pups. Stimulation of α2-ARs against the background of If blockade did not alter the HR dynamics in 3-week-old rats and abolished bidirectional HR changes in adult and 1-week-old animals, causing only a decrease in HR in adults and an increase in HR in newborns. The obtained results demonstrate that α2-adrenergic cardiac regulation is modulated by If, with the degree and direction of the effects depending on the maturity level of cardiac sympathetic innervation.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	alpha-2 adrenergic receptor	ru_RU
dc.subject	hyperpolarization-activated current	ru_RU
dc.subject	isolated heart	ru_RU
dc.subject	ontogenesis	ru_RU
dc.subject	rat	ru_RU
dc.title	Stimulation of Alpha-2 Adrenoreceptors against the Background of Hyperpolarization-Activated Current Blockade at Different Formation Stages of Cardiac Adrenergic Innervation	ru_RU
dc.type	Статьи в российских журналах и сборниках	ru_RU