| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2025 |
| Язык | английский |
|
Саляхутдинова Шахноза Матмурадовна, автор
|
|
Weisel John W., автор
Андрианова Изабелла Александровна, автор
Литвинов Рустем Игоревич, автор
Пешкова Алина Дмитриевна, автор
|
|
Саляхутдинова Шахноза Матмурадовна, автор
|
|
Сунбули Хетам , автор
|
| Библиографическое описание на языке оригинала |
Peshkova AD, Saliakhutdinova SM, Sounbuli K, Andrianova IA, Litvinov RI, Weisel JW. Blood Levels and Composition of Leukocyte-Platelet Aggregates in Inflammatory Diseases of Various Etiologies. Thromb Haemost. 2025 Dec 4. doi: 10.1055/a-2742-3449. Epub ahead of print. PMID: 41224208. |
| Аннотация |
Thrombosis and haemostasis |
| Ключевые слова |
leukocyte-platelet aggregates, neutrophils, monocytes, platelets, COVID-19, system lupus erythematosus, rheumatoid arthritis |
| Название журнала |
Thrombosis and haemostasis
|
| URL |
https://pubmed.ncbi.nlm.nih.gov/41224208/ |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=321753 |
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Саляхутдинова Шахноза Матмурадовна |
ru_RU |
| dc.contributor.author |
Weisel John W. |
ru_RU |
| dc.contributor.author |
Андрианова Изабелла Александровна |
ru_RU |
| dc.contributor.author |
Литвинов Рустем Игоревич |
ru_RU |
| dc.contributor.author |
Пешкова Алина Дмитриевна |
ru_RU |
| dc.contributor.author |
Сунбули Хетам |
ru_RU |
| dc.contributor.author |
Саляхутдинова Шахноза Матмурадовна |
ru_RU |
| dc.date.accessioned |
2025-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2025-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2025 |
ru_RU |
| dc.identifier.citation |
Peshkova AD, Saliakhutdinova SM, Sounbuli K, Andrianova IA, Litvinov RI, Weisel JW. Blood Levels and Composition of Leukocyte-Platelet Aggregates in Inflammatory Diseases of Various Etiologies. Thromb Haemost. 2025 Dec 4. doi: 10.1055/a-2742-3449. Epub ahead of print. PMID: 41224208. |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=321753 |
ru_RU |
| dc.description.abstract |
Thrombosis and haemostasis |
ru_RU |
| dc.description.abstract |
Leukocyte-platelet aggregates (LPAs) play a crucial role in the pathogenesis of inflammatory diseases, linking pathological immune responses with thrombosis.The levels of LPAs, their composition, and cellular reactivity were determined in patients with distinct inflammatory conditions, namely coronavirus disease 2019 (COVID-19), rheumatoid arthritis (RA), and systemic lupus erythematosus (SLE), compared with healthy controls. Flow cytometry was used to identify cell types and measure LPA levels in the blood. The ability of platelets, neutrophils, and monocytes to form additional LPAs in response to hyperstimulation with phorbol-12-myristate-13-acetate (PMA) was assessed. Coaggregation of isolated neutrophils and platelets in vitro was visualized using scanning electron microscopy. Blood tests included coagulation, hematology, biochemistry, and immunology.LPA levels were significantly higher in all patient groups compared with controls, with variations in the composition: neutrophil-platelet aggregates predominated in the COVID-19 patients, whereas monocyte-platelet aggregates prevailed in the blood of RA and SLE patients. Platelet-to-leukocyte ratios within aggregates varied in a broad range with a substantial prevalence of platelets over leukocytes. Morphological analysis revealed coaggregation of platelets with neutrophils, including relatively large homotypic platelet aggregates associated with one or two neutrophils. In PMA-treated pathological blood samples from COVID-19, RA, and SLE patients, the ability to form additional LPAs over the patients' baseline level was reduced compared with normal blood samples, indicating impaired reactivity (exhaustion) of neutrophils and monocytes in all patient groups.This study highlights distinct changes in the number and composition of LPAs in inflammatory diseases of various etiologies associated with altered functionality of the innate immune cells. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
leukocyte-platelet aggregates |
ru_RU |
| dc.subject |
neutrophils |
ru_RU |
| dc.subject |
monocytes |
ru_RU |
| dc.subject |
platelets |
ru_RU |
| dc.subject |
COVID-19 |
ru_RU |
| dc.subject |
system lupus erythematosus |
ru_RU |
| dc.subject |
rheumatoid arthritis |
ru_RU |
| dc.title |
Blood Levels and Composition of Leukocyte-Platelet Aggregates in Inflammatory Diseases of Various Etiologies |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
|
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