КФУ. Карточка публикации. Morphological and Functional Evaluation of Rat Leg Muscles under the Influence of Hindlimb Unloading, Tenotomy, and Denervation. Biochem

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MORPHOLOGICAL AND FUNCTIONAL EVALUATION OF RAT LEG MUSCLES UNDER THE INFLUENCE OF HINDLIMB UNLOADING, TENOTOMY, AND DENERVATION. BIOCHEM

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2026

Язык

русский

Авторы, сотрудники КФУ

Балтина Татьяна Валерьевна, автор

Еремеев Антон Александрович, автор

Хайруллин Адель Евгеньевич, автор

Авторы, аспиранты КФУ

Сабирова Диана Эмилевна, автор

Авторы, студенты КФУ

Шадрина Алена Александровна, автор

Библиографическое описание на языке оригинала

Sabirova, D.E. Morphological and Functional Evaluation of Rat Leg Muscles under the Influence of Hindlimb Unloading, Tenotomy, and Denervation. Biochem / D.E.Sabirova, A.A.Shadrina, A.A. Eremeev, A. E. Khairullin, T. V. Baltina // Moscow Suppl. Ser. A. - 2026. - V. 20. - P. 89–102.

Аннотация

Skeletal muscle atrophy can develop under the influence of various factors associated with their disuse, such as immobilization, denervation, or exposure to microgravity. The aim of the study was to conduct a morphological and functional assessment of the soleus, gastrocnemius, and tibialis anterior muscles in models of disuse in rats. The rats were randomly divided into a control group and groups subjected to denervation, tenotomy, and hindlimb unloading (HU). During the experiments, a decrease in muscle fiber diameter was observed in all experimental groups. Tenotomy resulted in a decrease in dystrophin immunoexpression. With HU, the level of dystrophin decreased, but by day 35, recovery was observed in the gastrocnemius and tibialis anterior muscles, while in the soleus muscle, the level continued to fall. After denervation, the dystrophin content also decreased but then increased, reaching control values in the soleus muscle by day 35. The level of neuronal NO synthase decreased significantly in all experimental groups. Denervation and tenotomy lead to pronounced changes in the contractile function of the soleus muscle in rats.

Ключевые слова

muscle atrophy, dystrophin, neuronal NO synthase, hindlimb unloading, denervation tenotomy

Название журнала

Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology

URL

https://link.springer.com/article/10.1134/S1990747825700606

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https://repository.kpfu.ru/?p_id=323065

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Балтина Татьяна Валерьевна	ru_RU
dc.contributor.author	Еремеев Антон Александрович	ru_RU
dc.contributor.author	Хайруллин Адель Евгеньевич	ru_RU
dc.contributor.author	Шадрина Алена Александровна	ru_RU
dc.contributor.author	Сабирова Диана Эмилевна	ru_RU
dc.date.accessioned	2026-01-01T00:00:00Z	ru_RU
dc.date.available	2026-01-01T00:00:00Z	ru_RU
dc.date.issued	2026	ru_RU
dc.identifier.citation	Sabirova, D.E. Morphological and Functional Evaluation of Rat Leg Muscles under the Influence of Hindlimb Unloading, Tenotomy, and Denervation. Biochem / D.E.Sabirova, A.A.Shadrina, A.A. Eremeev, A. E. Khairullin, T. V. Baltina // Moscow Suppl. Ser. A. - 2026. - V. 20. - P. 89–102.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=323065	ru_RU
dc.description.abstract	Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology	ru_RU
dc.description.abstract	Skeletal muscle atrophy can develop under the influence of various factors associated with their disuse, such as immobilization, denervation, or exposure to microgravity. The aim of the study was to conduct a morphological and functional assessment of the soleus, gastrocnemius, and tibialis anterior muscles in models of disuse in rats. The rats were randomly divided into a control group and groups subjected to denervation, tenotomy, and hindlimb unloading (HU). During the experiments, a decrease in muscle fiber diameter was observed in all experimental groups. Tenotomy resulted in a decrease in dystrophin immunoexpression. With HU, the level of dystrophin decreased, but by day 35, recovery was observed in the gastrocnemius and tibialis anterior muscles, while in the soleus muscle, the level continued to fall. After denervation, the dystrophin content also decreased but then increased, reaching control values in the soleus muscle by day 35. The level of neuronal NO synthase decreased significantly in all experimental groups. Denervation and tenotomy lead to pronounced changes in the contractile function of the soleus muscle in rats.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	muscle atrophy	ru_RU
dc.subject	dystrophin	ru_RU
dc.subject	neuronal NO synthase	ru_RU
dc.subject	hindlimb unloading	ru_RU
dc.subject	denervation tenotomy	ru_RU
dc.title	Morphological and Functional Evaluation of Rat Leg Muscles under the Influence of Hindlimb Unloading, Tenotomy, and Denervation. Biochem	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU