| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2013 |
| Язык | русский |
|
Зеленихин Павел Валерьевич, автор
Ильинская Ольга Николаевна, автор
Колпаков Алексей Иванович, автор
|
| Библиографическое описание на языке оригинала |
Cabrera-Fuentes, H.A. Internalization of Bacillus intermedius ribonuclease (BINASE) induces human alveolar adenocarcinoma cell death [Text] / H.A. Cabrera-Fuentes, M. Aslam, M. Saffarzadeh, A. Kolpakov, P. Zelenikhin, K.T. Preissner, O.N. Ilinskaya // Toxicon.- 2013.- V.69.- P.219-226 |
| Аннотация |
Toxicon |
| Ключевые слова |
Cytotoxic RNase, Binase, Human alveolar adenocarcinoma cells, Permeability, Internalization, DSB, Apoptosis |
| Название журнала |
Toxicon
|
| URL |
http://www.sciencedirect.com/science/article/pii/S0041010113001104 |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=79004 |
| Файлы ресурса | |
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|
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Зеленихин Павел Валерьевич |
ru_RU |
| dc.contributor.author |
Ильинская Ольга Николаевна |
ru_RU |
| dc.contributor.author |
Колпаков Алексей Иванович |
ru_RU |
| dc.date.accessioned |
2013-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2013-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2013 |
ru_RU |
| dc.identifier.citation |
Cabrera-Fuentes, H.A. Internalization of Bacillus intermedius ribonuclease (BINASE) induces human alveolar adenocarcinoma cell death [Text] / H.A. Cabrera-Fuentes, M. Aslam, M. Saffarzadeh, A. Kolpakov, P. Zelenikhin, K.T. Preissner, O.N. Ilinskaya // Toxicon.- 2013.- V.69.- P.219-226 |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=79004 |
ru_RU |
| dc.description.abstract |
Toxicon |
ru_RU |
| dc.description.abstract |
Toxicon |
ru_RU |
| dc.description.abstract |
Ribonuclease (RNase) treatment represents a novel mechanism based approach to anticancer therapy as an alternative to the DNA damaging drugs commonly used in clinical practice. Apart from their ribonucleolytic activity, cytotoxic effects have attracted a considerable attention to RNases because of their potential as selective agents for treatment of certain malignancies. Among these enzymes, Binase, an RNase from Bacillus intermedius, has shown promising results. Here, we have found that binase selectively attacked human A549 alveolar adenocarcinoma cells to trigger an apoptotic response, whereas normal lung epithelial cells LEK were not affected by the ribonuclease. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
Cytotoxic RNase |
ru_RU |
| dc.subject |
Binase |
ru_RU |
| dc.subject |
Human alveolar adenocarcinoma cells |
ru_RU |
| dc.subject |
Permeability |
ru_RU |
| dc.subject |
Internalization |
ru_RU |
| dc.subject |
DSB |
ru_RU |
| dc.subject |
Apoptosis |
ru_RU |
| dc.title |
Internalization of Bacillus intermedius ribonuclease (BINASE) induces human alveolar adenocarcinoma cell death. |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
|
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