КФУ. Карточка публикации. Low molecular weight polyethylene glycols as matrix to obtain solid dispersions of sulfanilamide

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LOW MOLECULAR WEIGHT POLYETHYLENE GLYCOLS AS MATRIX TO OBTAIN SOLID DISPERSIONS OF SULFANILAMIDE

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2014

Авторы, сотрудники КФУ

Герасимов Александр Владимирович, автор

Горбачук Валерий Виленович, автор

Зиганшин Марат Ахмедович, автор

Авторы, студенты КФУ

Усманова Лиана Станиславовна, автор

Библиографическое описание на языке оригинала

Gerasimov, A.V. Low molecular weight polyethylene glycols as matrix to obtain solid dispersions of sulfanilamide / A.V. Gerasimov, M.A. Ziganshin, V.V. Gorbatchuk, L.S. Usmanova // International Journal of Pharmacy and Pharmaceutical Sciences. – 2014. – V.6, N.6. – P.372-377.

Аннотация

Objective: The objective of the present study is a determination of optimal ratios of polyethylene glycol:sulfanilamide at which formation of solid dispersion is observed. Also study the effect of the polymer on the limiting solubility of sulfanilamide in water. Methods: Using low-temperature differential scanning calorimetry (DSC), it was made possible to obtain solid dispersions of sulfanilamide with polyethylene glycols having average molecular weight 1000 and 1400. UV-spectroscopy was used to determine the effect of polymer on limiting solubility of sulfanilamide. Results: An optimal polymer:sulfanilamide ratios are 7:1 and 4:1 for PEG-1000 and PEG-1400, respectively. Polymer in a drug composition allows for the increase the sulfanilamide content in water up to 3.0 times as compared with the solution of individual drug. Conclusion: These promising materials can be used for manufacture of drugs in various forms: capsular drugs, ointment and suppositories.

Ключевые слова

Solid dispersion, Sulfanilamide, Polyethylene glycol, Differential scanning calorimetry

Название журнала

International Journal of Pharmacy and Pharmaceutical Sciences

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https://repository.kpfu.ru/?p_id=84284

Файлы ресурса

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Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Герасимов Александр Владимирович	ru_RU
dc.contributor.author	Горбачук Валерий Виленович	ru_RU
dc.contributor.author	Зиганшин Марат Ахмедович	ru_RU
dc.contributor.author	Усманова Лиана Станиславовна	ru_RU
dc.date.accessioned	2014-01-01T00:00:00Z	ru_RU
dc.date.available	2014-01-01T00:00:00Z	ru_RU
dc.date.issued	2014	ru_RU
dc.identifier.citation	Gerasimov, A.V. Low molecular weight polyethylene glycols as matrix to obtain solid dispersions of sulfanilamide / A.V. Gerasimov, M.A. Ziganshin, V.V. Gorbatchuk, L.S. Usmanova // International Journal of Pharmacy and Pharmaceutical Sciences. – 2014. – V.6, N.6. – P.372-377.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=84284	ru_RU
dc.description.abstract	International Journal of Pharmacy and Pharmaceutical Sciences	ru_RU
dc.description.abstract	Objective: The objective of the present study is a determination of optimal ratios of polyethylene glycol:sulfanilamide at which formation of solid dispersion is observed. Also study the effect of the polymer on the limiting solubility of sulfanilamide in water. Methods: Using low-temperature differential scanning calorimetry (DSC), it was made possible to obtain solid dispersions of sulfanilamide with polyethylene glycols having average molecular weight 1000 and 1400. UV-spectroscopy was used to determine the effect of polymer on limiting solubility of sulfanilamide. Results: An optimal polymer:sulfanilamide ratios are 7:1 and 4:1 for PEG-1000 and PEG-1400, respectively. Polymer in a drug composition allows for the increase the sulfanilamide content in water up to 3.0 times as compared with the solution of individual drug. Conclusion: These promising materials can be used for manufacture of drugs in various forms: capsular drugs, ointment and suppositories.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Solid dispersion	ru_RU
dc.subject	Sulfanilamide	ru_RU
dc.subject	Polyethylene glycol	ru_RU
dc.subject	Differential scanning calorimetry	ru_RU
dc.title	Low molecular weight polyethylene glycols as matrix to obtain solid dispersions of sulfanilamide	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU