КФУ. Карточка публикации. Burlaka, A.P., Ganusevich, I.I., Lukin, S.N., Gafurov, M.R., Sidorik, E.P. Superoxide- and NO-Dependent Mechanisms of the Reprogramming of Bone Marrow Cells by Tumor Cells. Applied Magnetic Resonance 45 (11), 1261-1273 (2014). DOI: 10.1007/s00723-014-0610-y

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BURLAKA, A.P., GANUSEVICH, I.I., LUKIN, S.N., GAFUROV, M.R., SIDORIK, E.P. SUPEROXIDE- AND NO-DEPENDENT MECHANISMS OF THE REPROGRAMMING OF BONE MARROW CELLS BY TUMOR CELLS. APPLIED MAGNETIC RESONANCE 45 (11), 1261-1273 (2014). DOI: 10.1007/S00723-014-0610-Y

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2014

Авторы, сотрудники КФУ

Гафуров Марат Ревгерович, автор

Другие авторы

A. P. Burlaka; S.N. Likin; I. I. Ganusevich; E.P. Sidorik

Библиографическое описание на языке оригинала

Burlaka, A.P., Ganusevich, I.I., Lukin, S.N., Gafurov, M.R., Sidorik, E.P. Superoxide- and NO-Dependent Mechanisms of the Reprogramming of Bone Marrow Cells by Tumor Cells. Applied Magnetic Resonance 45 (11), 1261-1273 (2014). DOI: 10.1007/s00723-014-0610-y

Аннотация

Electron paramagnetic resonance (EPR) experiments in vitro; spin trapping of the reactive oxygen/nitrogen species (superoxide radicals and nitric oxide, NO); gel zymography measurements in the tumor tissues, in the healthy and tumor-affected bone marrow (BM) samples of rats are carried out. It is shown that the impact of tumor cells on BM manifests in the metabolic disorder, increased concentrations of active forms of MMP-2 and MMP-9,increased production of superoxide and NO radicals. The obtained spatial and temporal changes of the measured parameters demonstrate the usefulness of the potential application of EPR imaging to study the mechanisms of tumor invasion. The EPR signal may indicate the presence of distant metastases, may become a part of diagnostics and used for the estimation of the therapeutic treatments in the preclinical studies. It is proposed that labile iron pool is responsible for the appearance of the EPR signal in tumor and BM samples.

Ключевые слова

tumor, cancer, superoxide, nitric oxide, matrix metalloproteinases, incubation, EPR, ESR

Название журнала

Applied Magnetic Resonance

URL

http://link.springer.com/article/10.1007/s00723-014-0610-y

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https://repository.kpfu.ru/?p_id=90019

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Гафуров Марат Ревгерович	ru_RU
dc.date.accessioned	2014-01-01T00:00:00Z	ru_RU
dc.date.available	2014-01-01T00:00:00Z	ru_RU
dc.date.issued	2014	ru_RU
dc.identifier.citation	Burlaka, A.P., Ganusevich, I.I., Lukin, S.N., Gafurov, M.R., Sidorik, E.P. Superoxide- and NO-Dependent Mechanisms of the Reprogramming of Bone Marrow Cells by Tumor Cells. Applied Magnetic Resonance 45 (11), 1261-1273 (2014). DOI: 10.1007/s00723-014-0610-y	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=90019	ru_RU
dc.description.abstract	Applied Magnetic Resonance	ru_RU
dc.description.abstract	Electron paramagnetic resonance (EPR) experiments in vitro; spin trapping of the reactive oxygen/nitrogen species (superoxide radicals and nitric oxide, NO); gel zymography measurements in the tumor tissues, in the healthy and tumor-affected bone marrow (BM) samples of rats are carried out. It is shown that the impact of tumor cells on BM manifests in the metabolic disorder, increased concentrations of active forms of MMP-2 and MMP-9,increased production of superoxide and NO radicals. The obtained spatial and temporal changes of the measured parameters demonstrate the usefulness of the potential application of EPR imaging to study the mechanisms of tumor invasion. The EPR signal may indicate the presence of distant metastases, may become a part of diagnostics and used for the estimation of the therapeutic treatments in the preclinical studies. It is proposed that labile iron pool is responsible for the appearance of the EPR signal in tumor and BM samples.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	tumor	ru_RU
dc.subject	cancer	ru_RU
dc.subject	superoxide	ru_RU
dc.subject	nitric oxide	ru_RU
dc.subject	matrix metalloproteinases	ru_RU
dc.subject	incubation	ru_RU
dc.subject	EPR	ru_RU
dc.subject	ESR	ru_RU
dc.title	Burlaka, A.P., Ganusevich, I.I., Lukin, S.N., Gafurov, M.R., Sidorik, E.P. Superoxide- and NO-Dependent Mechanisms of the Reprogramming of Bone Marrow Cells by Tumor Cells. Applied Magnetic Resonance 45 (11), 1261-1273 (2014). DOI: 10.1007/s00723-014-0610-y	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU