КФУ. Карточка публикации. Genetic Modification of Adipose Derived Stem Cells with Recombinant Plasmid DNA pBud-VEGF-FGF2 Results in Increased of IL-8 and MCP-1 Secretion

RUS

- EN
- 中文
- ES

GENETIC MODIFICATION OF ADIPOSE DERIVED STEM CELLS WITH RECOMBINANT PLASMID DNA PBUD-VEGF-FGF2 RESULTS IN INCREASED OF IL-8 AND MCP-1 SECRETION

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2014

Язык

английский

Авторы, сотрудники КФУ

Масгутов Руслан Фаридович, автор

Салафутдинов Ильнур Ильдусович, автор

Соловьева Валерия Владимировна, автор

Тазетдинова Лейсан Газинуровна, автор

Хайбуллина Светлана Францевна, автор

Авторы, аспиранты КФУ

Тазетдинова Лейсан Газинуровна, автор

Библиографическое описание на языке оригинала

Solovyeva V.V. Genetic Modification of Adipose Derived Stem Cells with Recombinant Plasmid DNA pBud-VEGF-FGF2 Results in Increased of IL-8 and MCP-1 Secretion / V.V. Solovyeva, I.I. Salafutdinov, L.G. Tazetdinova, R.F. Masgutov, S.F. Khaiboullina, A.A. Rizvanov // Journal of pure and applied microbiology. – 2014. – Vol.8, Spl.Edn.2. – P.523-528.

Аннотация

Bacterial plasmid DNA is often used in gene therapy application as a vector for delivering recombinant genes into eukaryotic cells. In this work we study effect of plasmid DNA encoding pro-angiogenic growth factors VEGF and FGF2 on cytokine production of human adipose derived stem cells (ADSC). Adipose tissue contain progenitor and stem cells with angiogenic potential which are considered promising cell source for treating ischemic conditions. Genetic modification of human ADSC with recombinant plasmids encoding therapeutic growth factors might change therapeutic potential of these cells. We report that genetic modification of ADSC with recombinant plasmid pBud-VEGF-FGF2 results in expected increased of VEGF secretion and also results in increase of IL-8 and MCP-1 secretion into culture medium.

Ключевые слова

bacterial plasmid DNA, cytokines, chemokines, human adipose derived stem cells, stromal vascular fraction, vascular endothelial growth factor, basic fibroblast growth factor, genetic modification

Название журнала

Journal of pure and applied microbiology

URL

http://microbiologyjournal.org/jmabsread.php?snoid=2279&month=&year=

Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку

https://repository.kpfu.ru/?p_id=93677

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Масгутов Руслан Фаридович	ru_RU
dc.contributor.author	Салафутдинов Ильнур Ильдусович	ru_RU
dc.contributor.author	Соловьева Валерия Владимировна	ru_RU
dc.contributor.author	Тазетдинова Лейсан Газинуровна	ru_RU
dc.contributor.author	Хайбуллина Светлана Францевна	ru_RU
dc.contributor.author	Тазетдинова Лейсан Газинуровна	ru_RU
dc.date.accessioned	2014-01-01T00:00:00Z	ru_RU
dc.date.available	2014-01-01T00:00:00Z	ru_RU
dc.date.issued	2014	ru_RU
dc.identifier.citation	Solovyeva V.V. Genetic Modification of Adipose Derived Stem Cells with Recombinant Plasmid DNA pBud-VEGF-FGF2 Results in Increased of IL-8 and MCP-1 Secretion / V.V. Solovyeva, I.I. Salafutdinov, L.G. Tazetdinova, R.F. Masgutov, S.F. Khaiboullina, A.A. Rizvanov // Journal of pure and applied microbiology. – 2014. – Vol.8, Spl.Edn.2. – P.523-528.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=93677	ru_RU
dc.description.abstract	Journal of pure and applied microbiology	ru_RU
dc.description.abstract	Bacterial plasmid DNA is often used in gene therapy application as a vector for delivering recombinant genes into eukaryotic cells. In this work we study effect of plasmid DNA encoding pro-angiogenic growth factors VEGF and FGF2 on cytokine production of human adipose derived stem cells (ADSC). Adipose tissue contain progenitor and stem cells with angiogenic potential which are considered promising cell source for treating ischemic conditions. Genetic modification of human ADSC with recombinant plasmids encoding therapeutic growth factors might change therapeutic potential of these cells. We report that genetic modification of ADSC with recombinant plasmid pBud-VEGF-FGF2 results in expected increased of VEGF secretion and also results in increase of IL-8 and MCP-1 secretion into culture medium.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	bacterial plasmid DNA	ru_RU
dc.subject	cytokines	ru_RU
dc.subject	chemokines	ru_RU
dc.subject	human adipose derived stem cells	ru_RU
dc.subject	stromal vascular fraction	ru_RU
dc.subject	vascular endothelial growth factor	ru_RU
dc.subject	basic fibroblast growth factor	ru_RU
dc.subject	genetic modification	ru_RU
dc.title	Genetic Modification of Adipose Derived Stem Cells with Recombinant Plasmid DNA pBud-VEGF-FGF2 Results in Increased of IL-8 and MCP-1 Secretion	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU