КФУ. Карточка публикации. Over-expression of oct4 and sox2 transcription factors enhances differentiation of human umbilical cord blood cells in vivo

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OVER-EXPRESSION OF OCT4 AND SOX2 TRANS&SHY;CRIPTION FACTORS ENHANCES DIFFERENTIATION OF HUMAN UMBILICAL CORD BLOOD CELLS IN VIVO

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2014

Авторы, сотрудники КФУ

Салафутдинов Ильнур Ильдусович, автор

Другие авторы

D. Guseva; A. Palotás; R.R. Islamov

Авторы, аспиранты КФУ

Кудряшова Неждана Владимировна, автор

Библиографическое описание на языке оригинала

Guseva D. Over-expression of oct4 and sox2 transcription factors enhances differentiation of human umbilical cord blood cells in vivo / D. Guseva, A.A. Rizvanov, I.I. Salafutdinov, N.V. Kudryashova, A. Palotás, R.R. Islamov // Biochem Biophys Res Commun. - 2014. - Vol.451, Issue 4. - P.503-509.

Аннотация

Gene and cell-based therapies comprise innovative aspects of regenerative medicine. Even though stem cells represent a highly potential therapeutic strategy, their wide-spread exploitation is marred by ethical concerns, potential for malignant transformation and a plethora of other technical issues, largely restricting their use to experimental studies. Utilizing genetically modified human umbilical cord blood mono-nuclear cells (hUCB-MCs), this communication reports enhanced differentiation of transplants in a mouse model of amyotrophic lateral sclerosis (ALS). Over-expressing Oct4 and Sox2 induced production of neural marker PGP9.5, as well as transformation of hUCB-MCs into micro-glial and endothelial lines in ALS spinal cords. In addition to producing new nerve cells, providing degenerated areas with trophic factors and neo-vascularisation might prevent and even reverse progressive loss of moto-neurons and skeletal muscle paralysis.

Ключевые слова

Amyotrophic lateral sclerosis, Differentiation, Umbilical cord blood mono-nuclear cell, Pluripotency, Transcription factor

Название журнала

BIOCHEM BIOPH RES CO

URL

http://www.sciencedirect.com/science/article/pii/S0006291X14013953

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https://repository.kpfu.ru/?p_id=93686

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Салафутдинов Ильнур Ильдусович	ru_RU
dc.contributor.author	Кудряшова Неждана Владимировна	ru_RU
dc.date.accessioned	2014-01-01T00:00:00Z	ru_RU
dc.date.available	2014-01-01T00:00:00Z	ru_RU
dc.date.issued	2014	ru_RU
dc.identifier.citation	Guseva D. Over-expression of oct4 and sox2 transcription factors enhances differentiation of human umbilical cord blood cells in vivo / D. Guseva, A.A. Rizvanov, I.I. Salafutdinov, N.V. Kudryashova, A. Palotás, R.R. Islamov // Biochem Biophys Res Commun. - 2014. - Vol.451, Issue 4. - P.503-509.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=93686	ru_RU
dc.description.abstract	BIOCHEM BIOPH RES CO	ru_RU
dc.description.abstract	Gene and cell-based therapies comprise innovative aspects of regenerative medicine. Even though stem cells represent a highly potential therapeutic strategy, their wide-spread exploitation is marred by ethical concerns, potential for malignant transformation and a plethora of other technical issues, largely restricting their use to experimental studies. Utilizing genetically modified human umbilical cord blood mono-nuclear cells (hUCB-MCs), this communication reports enhanced differentiation of transplants in a mouse model of amyotrophic lateral sclerosis (ALS). Over-expressing Oct4 and Sox2 induced production of neural marker PGP9.5, as well as transformation of hUCB-MCs into micro-glial and endothelial lines in ALS spinal cords. In addition to producing new nerve cells, providing degenerated areas with trophic factors and neo-vascularisation might prevent and even reverse progressive loss of moto-neurons and skeletal muscle paralysis.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Amyotrophic lateral sclerosis	ru_RU
dc.subject	Differentiation	ru_RU
dc.subject	Umbilical cord blood mono-nuclear cell	ru_RU
dc.subject	Pluripotency	ru_RU
dc.subject	Transcription factor	ru_RU
dc.title	Over-expression of oct4 and sox2 transcription factors enhances differentiation of human umbilical cord blood cells in vivo	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU