КФУ. Карточка публикации. Upregulation of IFN-γ and IL-12 is associated with a milder form of hantavirus hemorrhagic fever with renal syndrome

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UPREGULATION OF IFN-γ AND IL-12 IS ASSOCIATED WITH A MILDER FORM OF HANTAVIRUS HEMORRHAGIC FEVER WITH RENAL SYNDROME

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2014

Авторы, сотрудники КФУ

Ломбарди Винсент Клиффорд , автор

Мартынова Екатерина Владимировна, автор

Хайбуллина Светлана Францевна, автор

Другие авторы

Z.L. Khamidullina; E.V. Lapteva; I.V. Nikolaeva; V.V. Anokhin

Библиографическое описание на языке оригинала

Khaiboullina S.F. Upregulation of IFN-γ and IL-12 is associated with a milder form of hantavirus hemorrhagic fever with renal syndrome / S.F. Khaiboullina, E.V. Martynova, Z.L. Khamidullina, E.V. Lapteva, I.V. Nikolaeva, V.V. Anokhin, V.C. Lombardi, A.A. Rizvanov // European Journal of Clinical Microbiology & Infectious Diseases. – 2014. – Vol.33, Issue 12. - P.2149-56.

Аннотация

Eur J Clin Microbiol Infect Dis

Ключевые слова

Hantavirus, Hantavirus hemorrhagic fever with renal syndrome, cytokines

Название журнала

Eur J Clin Microbiol Infect Dis

URL

http://www.ncbi.nlm.nih.gov/pubmed/24942310

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https://repository.kpfu.ru/?p_id=93694

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Ломбарди Винсент Клиффорд	ru_RU
dc.contributor.author	Мартынова Екатерина Владимировна	ru_RU
dc.contributor.author	Хайбуллина Светлана Францевна	ru_RU
dc.date.accessioned	2014-01-01T00:00:00Z	ru_RU
dc.date.available	2014-01-01T00:00:00Z	ru_RU
dc.date.issued	2014	ru_RU
dc.identifier.citation	Khaiboullina S.F. Upregulation of IFN-γ and IL-12 is associated with a milder form of hantavirus hemorrhagic fever with renal syndrome / S.F. Khaiboullina, E.V. Martynova, Z.L. Khamidullina, E.V. Lapteva, I.V. Nikolaeva, V.V. Anokhin, V.C. Lombardi, A.A. Rizvanov // European Journal of Clinical Microbiology & Infectious Diseases. – 2014. – Vol.33, Issue 12. - P.2149-56.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=93694	ru_RU
dc.description.abstract	Eur J Clin Microbiol Infect Dis	ru_RU
dc.description.abstract	Hantavirus hemorrhagic fever with renal syndrome (HFRS) is a zoonotic disease characterized by acute onset, fever, malaise, and back pain. As the disease progresses, hemorrhagic disturbances and kidney dysfunctions predominate. The examination of tissue collected postmortem supports the premise that virus replication is not responsible for this pathology; therefore, it is widely believed that virus-induced immune responses lead to the clinical manifestations associated with HFRS. The overproduction of inflammatory cytokines is commonly reported in subjects with HFRS and has given rise to the hypothesis that a so-called "cytokine storm" may play a pivotal role in the pathogenesis of this disease. Currently, supportive care remains the only effective treatment for HFRS. Our data show that serum levels of interferon (IFN)-γ, interleukin (IL)-10, CCL2, and IL-12 are upregulated in HFRS cases when compared to healthy controls and the level of upregulation is dependent on the phase and sever	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Hantavirus	ru_RU
dc.subject	Hantavirus hemorrhagic fever with renal syndrome	ru_RU
dc.subject	cytokines	ru_RU
dc.title	Upregulation of IFN-γ and IL-12 is associated with a milder form of hantavirus hemorrhagic fever with renal syndrome	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU