КФУ. Карточка публикации. Human dendritic cells transfected with a human papilloma virus-18 construct display decreased mobility and upregulated cytokine production

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HUMAN DENDRITIC CELLS TRANSFECTED WITH A HUMAN PAPILLOMA VIRUS-18 CONSTRUCT DISPLAY DECREASED MOBILITY AND UPREGULATED CYTOKINE PRODUCTION

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2013

Авторы, сотрудники КФУ

Ломбарди Винсент Клиффорд , автор

Ризванов Альберт Анатольевич, автор

Хайбуллина Светлана Францевна, автор

Другие авторы

S.P. Morzunov; M.R. Hall; K.L. De Meirleir

Библиографическое описание на языке оригинала

Khaiboullina S.F. Human dendritic cells transfected with a human papilloma virus-18 construct display decreased mobility and upregulated cytokine production / S.F. Khaiboullina, S.P. Morzunov, M.R. Hall, K.L. De Meirleir, A.A. Rizvanov and V.C. Lombardi // International Journal of Oncology. – 2013. – Vol. 43, No.5. – P.1701-1709.

Аннотация

International Journal of Oncology

Ключевые слова

Human dendritic cells

Название журнала

International Journal of Oncology

URL

http://www.ncbi.nlm.nih.gov/pubmed/23969559

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https://repository.kpfu.ru/?p_id=93707

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Ломбарди Винсент Клиффорд	ru_RU
dc.contributor.author	Ризванов Альберт Анатольевич	ru_RU
dc.contributor.author	Хайбуллина Светлана Францевна	ru_RU
dc.date.accessioned	2013-01-01T00:00:00Z	ru_RU
dc.date.available	2013-01-01T00:00:00Z	ru_RU
dc.date.issued	2013	ru_RU
dc.identifier.citation	Khaiboullina S.F. Human dendritic cells transfected with a human papilloma virus-18 construct display decreased mobility and upregulated cytokine production / S.F. Khaiboullina, S.P. Morzunov, M.R. Hall, K.L. De Meirleir, A.A. Rizvanov and V.C. Lombardi // International Journal of Oncology. – 2013. – Vol. 43, No.5. – P.1701-1709.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=93707	ru_RU
dc.description.abstract	International Journal of Oncology	ru_RU
dc.description.abstract	The marked depletion of dendritic cells (DCs) in skin cancers, as well as preneoplastic and neoplastic cervical epithelium, suggests a central role for DCs in productive human papillomavirus (HPV) infection and cancer promotion. It has been suggested that HPV may facilitate tumor development by reducing DC density, contributing to a decrease in local immune surveillance. In this study, we have examined the response of human DCs transfected with a construct containing the HPV18 genome and their subsequent expression of papilloma virus proteins. Transfected cells expressed the L1 major capsid protein and upregulated E6 and E7 oncoprotein transcripts as detected by RT-PCR. Transfection of DCs also resulted in a significant increase in cytokine production. Finally, we observed that HPV18 transfection decreased the migratory activity of DCs.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	Human dendritic cells transfected with a human papilloma virus-18 construct display decreased mobility and upregulated cytokine production	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU