| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2013 |
| Язык | английский |
|
Абдулхаков Сайяр Рустамович, автор
Гаранина Екатерина Евгеньевна, автор
Калигин Максим Сергеевич, автор
Киясов Андрей Павлович, автор
Ризванов Альберт Анатольевич, автор
Салафутдинов Ильнур Ильдусович, автор
Соловьева Валерия Владимировна, автор
|
|
Гаранина Екатерина Евгеньевна, автор
Федотова Валерия Юрьевна, автор
|
| Библиографическое описание на языке оригинала |
Mukhamedyarov M.A. Analysis of the efficiency of gene-cell therapy in transgenic mice with amyotrophic lateral sclerosis phenotype / M.A. Mukhamedyarov, A.A. Rizvanov, Z.Z. Safiullov, A.A. Izmailov, G.A. Sharifullina, V.V. Solovieva, V.Yu. Fedotova, I.I. Salafutdinov, E.E. Cherenkova, F.V. Bashirov, M.S. Kaligin, S.R. Abdulkhakov, M.M. Shmarov, D.Yu. Logunov, B.S. Naroditsky, A.P. Kiyasov, A.L. Zefirov, R.R. Islamov // Bulletin of Experimental Biology and Medicine. - Vol.154, №4. - P.558-561. |
| Аннотация |
Amyotrophic lateral sclerosis is a neurodegenerative disease characterized by progressive death of cerebral and spinal motorneurons. Using behavioral tests we studied the efficiency of gene-cell therapy in SOD1 G93A transgenic mice receiving xenotransplantation of human umbilical cord blood mononuclear cells genetically modified with adenoviral vectors encoding vascular endothelial growth factor (VEGF) and reporter green fluorescent protein (EGFP) genes. The cells were transplanted to mice on week 27 of life (preclinical stage of the disease). Behavioral tests (open field, grip strength test) showed that transplantation of umbilical cord blood mononuclear cells expressing VEGF significantly improved the parameters of motor and explorative activity, grip strength, and animal survival. Thus, gene-cell therapy based on genetically modified mononuclear cells expressing VEGF can be efficient for the treatment of amyotrophic lateral sclerosis. |
| Ключевые слова |
amyotrophic lateral sclerosis, gene-cell therapy, SOD1-G93A, transgenic mice, vascular endothelial growth factor, human umbilical cord blood mononuclear cells |
| Название журнала |
Bulletin of Experimental Biology and Medicine
|
| URL |
http://www.ncbi.nlm.nih.gov/pubmed/23486603http://www.ncbi.nlm.nih.gov/pubmed/23486603 |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=94048 |
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Абдулхаков Сайяр Рустамович |
ru_RU |
| dc.contributor.author |
Гаранина Екатерина Евгеньевна |
ru_RU |
| dc.contributor.author |
Калигин Максим Сергеевич |
ru_RU |
| dc.contributor.author |
Киясов Андрей Павлович |
ru_RU |
| dc.contributor.author |
Ризванов Альберт Анатольевич |
ru_RU |
| dc.contributor.author |
Салафутдинов Ильнур Ильдусович |
ru_RU |
| dc.contributor.author |
Соловьева Валерия Владимировна |
ru_RU |
| dc.contributor.author |
Гаранина Екатерина Евгеньевна |
ru_RU |
| dc.contributor.author |
Федотова Валерия Юрьевна |
ru_RU |
| dc.date.accessioned |
2013-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2013-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2013 |
ru_RU |
| dc.identifier.citation |
Mukhamedyarov M.A. Analysis of the efficiency of gene-cell therapy in transgenic mice with amyotrophic lateral sclerosis phenotype / M.A. Mukhamedyarov, A.A. Rizvanov, Z.Z. Safiullov, A.A. Izmailov, G.A. Sharifullina, V.V. Solovieva, V.Yu. Fedotova, I.I. Salafutdinov, E.E. Cherenkova, F.V. Bashirov, M.S. Kaligin, S.R. Abdulkhakov, M.M. Shmarov, D.Yu. Logunov, B.S. Naroditsky, A.P. Kiyasov, A.L. Zefirov, R.R. Islamov // Bulletin of Experimental Biology and Medicine. - Vol.154, №4. - P.558-561. |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=94048 |
ru_RU |
| dc.description.abstract |
Bulletin of Experimental Biology and Medicine |
ru_RU |
| dc.description.abstract |
Amyotrophic lateral sclerosis is a neurodegenerative disease characterized by progressive death of cerebral and spinal motorneurons. Using behavioral tests we studied the efficiency of gene-cell therapy in SOD1 G93A transgenic mice receiving xenotransplantation of human umbilical cord blood mononuclear cells genetically modified with adenoviral vectors encoding vascular endothelial growth factor (VEGF) and reporter green fluorescent protein (EGFP) genes. The cells were transplanted to mice on week 27 of life (preclinical stage of the disease). Behavioral tests (open field, grip strength test) showed that transplantation of umbilical cord blood mononuclear cells expressing VEGF significantly improved the parameters of motor and explorative activity, grip strength, and animal survival. Thus, gene-cell therapy based on genetically modified mononuclear cells expressing VEGF can be efficient for the treatment of amyotrophic lateral sclerosis. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
amyotrophic lateral sclerosis |
ru_RU |
| dc.subject |
gene-cell therapy |
ru_RU |
| dc.subject |
SOD1-G93A |
ru_RU |
| dc.subject |
transgenic mice |
ru_RU |
| dc.subject |
vascular endothelial growth factor |
ru_RU |
| dc.subject |
human umbilical cord blood mononuclear cells |
ru_RU |
| dc.title |
Analysis of the efficiency of gene-cell therapy in transgenic mice with amyotrophic lateral sclerosis phenotype |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
|
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