КФУ. Карточка публикации. Effects of Transplantation of Human Cord Blood Mononuclear Cells Expressing the Recombinant VEGF and FGF2 Genes into Spinal Cord Traumatic Injury Sites in Rats

RUS

- EN
- 中文
- ES

EFFECTS OF TRANSPLANTATION OF HUMAN CORD BLOOD MONONUCLEAR CELLS EXPRESSING THE RECOMBINANT VEGF AND FGF2 GENES INTO SPINAL CORD TRAUMATIC INJURY SITES IN RATS

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2013

Авторы, сотрудники КФУ

Мухамедшина Яна Олеговна, автор

Ризванов Альберт Анатольевич, автор

Салафутдинов Ильнур Ильдусович, автор

Другие авторы

G.F. Shaimardanova; Yu.A. Chelyshev

Библиографическое описание на языке оригинала

Shaimardanova G.F. Effects of Transplantation of Human Cord Blood Mononuclear Cells Expressing the Recombinant VEGF and FGF2 Genes into Spinal Cord Traumatic Injury Sites in Rats / G.F. Shaimardanova, Ya.O. Mukhamedshina, A.A. Rizvanov, I.I. Salafutdinov, Yu.A. Chelyshev // Neuroscience and Behavioral Physiology. – 2013. – Vol.43, No.5. – P.597-601.

Аннотация

A model of dosed TVIII spinal cord contusion trauma in rats was used to study the effects of immediate single-dose transplantation of human cord blood mononuclear cells transformed with the recombinant genes for neurotrophic factors ? vascular endothelia growth factor (VEGF) and fibroblast growth factor 2 (FGF2) ? into the injury zone. A further group of animals, in the same conditions, received the same cells transfected with plasmid pEGFP-N2. EGFP-labeled cells were detected in the white matter for 21 days after transplantation at distances of at least 10 mm in the rostral and caudal directions from the administration point. By 30 days after transplantation with cells transfected with plasmid pBud-VEGF-FGF2, the area of intact gray matter 3 mm from the trauma epicenter increased by more than 60%.

Ключевые слова

spinal cord, regeneration, cord blood cells, VEGF, FGF2

Название журнала

Neuroscience and Behavioral Physiology

URL

http://download.springer.com/static/pdf/302/art%253A10.1007%252Fs11055-013-9778-0.pdf?auth66=1418904581_6b9e8dafa09e22d6a8916cf1a4d71167&ext=.pdf

Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку

https://repository.kpfu.ru/?p_id=94161

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Мухамедшина Яна Олеговна	ru_RU
dc.contributor.author	Ризванов Альберт Анатольевич	ru_RU
dc.contributor.author	Салафутдинов Ильнур Ильдусович	ru_RU
dc.date.accessioned	2013-01-01T00:00:00Z	ru_RU
dc.date.available	2013-01-01T00:00:00Z	ru_RU
dc.date.issued	2013	ru_RU
dc.identifier.citation	Shaimardanova G.F. Effects of Transplantation of Human Cord Blood Mononuclear Cells Expressing the Recombinant VEGF and FGF2 Genes into Spinal Cord Traumatic Injury Sites in Rats / G.F. Shaimardanova, Ya.O. Mukhamedshina, A.A. Rizvanov, I.I. Salafutdinov, Yu.A. Chelyshev // Neuroscience and Behavioral Physiology. – 2013. – Vol.43, No.5. – P.597-601.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=94161	ru_RU
dc.description.abstract	Neuroscience and Behavioral Physiology	ru_RU
dc.description.abstract	A model of dosed TVIII spinal cord contusion trauma in rats was used to study the effects of immediate single-dose transplantation of human cord blood mononuclear cells transformed with the recombinant genes for neurotrophic factors ? vascular endothelia growth factor (VEGF) and fibroblast growth factor 2 (FGF2) ? into the injury zone. A further group of animals, in the same conditions, received the same cells transfected with plasmid pEGFP-N2. EGFP-labeled cells were detected in the white matter for 21 days after transplantation at distances of at least 10 mm in the rostral and caudal directions from the administration point. By 30 days after transplantation with cells transfected with plasmid pBud-VEGF-FGF2, the area of intact gray matter 3 mm from the trauma epicenter increased by more than 60%.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	spinal cord	ru_RU
dc.subject	regeneration	ru_RU
dc.subject	cord blood cells	ru_RU
dc.subject	VEGF	ru_RU
dc.subject	FGF2	ru_RU
dc.title	Effects of Transplantation of Human Cord Blood Mononuclear Cells Expressing the Recombinant VEGF and FGF2 Genes into Spinal Cord Traumatic Injury Sites in Rats	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU