КФУ. Карточка публикации. Andes-virus-induced cytokine storm is partially suppressed by Ribavirin

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ФЕДЕРАЛЬНЫЙ УНИВЕРСИТЕТ

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ANDES-VIRUS-INDUCED CYTOKINE STORM IS PARTIALLY SUPPRESSED BY RIBAVIRIN

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2013

Авторы, сотрудники КФУ

Ломбарди Винсент Клиффорд , автор

Ризванов Альберт Анатольевич, автор

Хайбуллина Светлана Францевна, автор

Другие авторы

S.P. Morzunov; H.J. Reis; A. Palotás; S. Jeor

Библиографическое описание на языке оригинала

Khaiboullina S.F. Andes-virus-induced cytokine storm is partially suppressed by Ribavirin / S.F. Khaiboullina, A.A. Rizvanov, V.C. Lombardi, S.P. Morzunov, H.J. Reis, A. Palotás, S. Jeor // Antiviral Therapy. – 2013. – Vol.18, No.4. – P.575-584.

Аннотация

Microbe-induced over-activation of cytokines, especially tumour necrosis factor (TNF)-α, is key to the pathogenesis of hantavirus infection leading to severe inflammation with high mortality rate. Although ribavirin showed promise in inhibiting viral replication in vitro, its clinical efficacy remains controversial. Ribavirin decreased the virus load and dose-dependently inhibited the accumulation of RANTES messenger RNA in Andes-virus (ANDV)-infected human endothelial cells, but failed to suppress TNF-α-induced activation of RANTES and interleukin-6 in ANDV-inoculated cultures. This report also shows, for the first time, that the deleterious over-stimulation by TNF-α is mediated by nuclear factor-κB, and describes the effect of ribavirin on cytokine production following ANDV infection.

Ключевые слова

Cytokines, Ribavirin, Andes-virus

Название журнала

ANTIVIR THER

URL

http://www.ncbi.nlm.nih.gov/pubmed/23300158

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https://repository.kpfu.ru/?p_id=94166

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Ломбарди Винсент Клиффорд	ru_RU
dc.contributor.author	Ризванов Альберт Анатольевич	ru_RU
dc.contributor.author	Хайбуллина Светлана Францевна	ru_RU
dc.date.accessioned	2013-01-01T00:00:00Z	ru_RU
dc.date.available	2013-01-01T00:00:00Z	ru_RU
dc.date.issued	2013	ru_RU
dc.identifier.citation	Khaiboullina S.F. Andes-virus-induced cytokine storm is partially suppressed by Ribavirin / S.F. Khaiboullina, A.A. Rizvanov, V.C. Lombardi, S.P. Morzunov, H.J. Reis, A. Palotás, S. Jeor // Antiviral Therapy. – 2013. – Vol.18, No.4. – P.575-584.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=94166	ru_RU
dc.description.abstract	ANTIVIR THER	ru_RU
dc.description.abstract	Microbe-induced over-activation of cytokines, especially tumour necrosis factor (TNF)-α, is key to the pathogenesis of hantavirus infection leading to severe inflammation with high mortality rate. Although ribavirin showed promise in inhibiting viral replication in vitro, its clinical efficacy remains controversial. Ribavirin decreased the virus load and dose-dependently inhibited the accumulation of RANTES messenger RNA in Andes-virus (ANDV)-infected human endothelial cells, but failed to suppress TNF-α-induced activation of RANTES and interleukin-6 in ANDV-inoculated cultures. This report also shows, for the first time, that the deleterious over-stimulation by TNF-α is mediated by nuclear factor-κB, and describes the effect of ribavirin on cytokine production following ANDV infection.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Cytokines	ru_RU
dc.subject	Ribavirin	ru_RU
dc.subject	Andes-virus	ru_RU
dc.title	Andes-virus-induced cytokine storm is partially suppressed by Ribavirin	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU