Казанский (Приволжский) федеральный университет, КФУ
КАЗАНСКИЙ
ФЕДЕРАЛЬНЫЙ УНИВЕРСИТЕТ
 
PLASMACYTOID DENDRITIC CELLS IN THE DUODENUM OF INDIVIDUALS DIAGNOSED WITH MYALGIC ENCEPHALOMYELITIS ARE UNIQUELY IMMUNOREACTIVE TO ANTIBODIES TO HUMAN ENDOGENOUS RETROVIRAL PROTEINS
Форма представленияСтатьи в зарубежных журналах и сборниках
Год публикации2013
  • Ломбарди Винсент Клиффорд , автор
  • Ризванов Альберт Анатольевич, автор
  • Хайбуллина Светлана Францевна, автор
  • Другие авторы K.L. De Meirleir; M. Frémont; J. Hulstaert; A. Palotás
    Библиографическое описание на языке оригинала De Meirleir K.L. Plasmacytoid dendritic cells in the duodenum of individuals diagnosed with myalgic encephalomyelitis are uniquely immunoreactive to antibodies to human endogenous retroviral proteins / K.L. De Meirleir, S.F. Khaiboullina, M. Frémont, J. Hulstaert, A.A. Rizvanov, A. Palotás, V.C. Lombardi // IN VIVO. – 2013. – Vol.27, No.2. – P.177-187.
    Аннотация Myalgic encephalomyelitis (ME) is a debilitating illness of unknown etiology characterized by neurocognitive dysfunction, inflammation, immune abnormalities and gastrointestinal distress. An increasing body of evidence suggests that disruptions in the gut may contribute to the induction of neuroinflammation. Therefore, reports of human endogenous retroviral (HERV) expression in association with neuroinflammatory diseases prompted us to investigate the gut of individuals with ME for the presence of HERV proteins. In eight out of 12 individuals with ME, immunoreactivity to HERV proteins was observed in duodenal biopsies. In contrast, no immunoreactivity was detected in any of the eight controls. Immunoreactivity to HERV Gag and Env proteins was uniquely co-localized in hematopoietic cells expressing the C-type lectin receptor CLEC4C (CD303/BDCA2), the co-stimulatory marker CD86 and the class II major histocompatibility complex HLA-DR, consistent with plasmacytoid dendritic cells (pDCs).
    Ключевые слова Myalgic encephalomyelitis, ME, human endogenous retrovirus, HERV, plasmacytoid dendritic cell, pDC
    Название журнала IN VIVO
    URL http://www.ncbi.nlm.nih.gov/pubmed/23422476
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