КФУ. Карточка публикации. Symptomatic Improvement, Increased Life-Span and Sustained Cell Homing in Amyotrophic Lateral Sclerosis After Transplantation of Human Umbilical Cord Blood Cells Genetically Modified with Adeno-Viral Vectors Expressing a Neuro-Protective Factor and a Neural Cell Adhesion Molecule

RUS

- EN
- 中文
- ES

SYMPTOMATIC IMPROVEMENT, INCREASED LIFE-SPAN AND SUSTAINED CELL HOMING IN AMYOTROPHIC LATERAL SCLEROSIS AFTER TRANSPLANTATION OF HUMAN UMBILICAL CORD BLOOD CELLS GENETICALLY MODIFIED WITH ADENO-VIRAL VECTORS EXPRESSING A NEURO-PROTECTIVE FACTOR AND A NEURAL CELL ADHESION MOLECULE

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2015

Язык

английский

Авторы, сотрудники КФУ

Исламов Рустем Робертович, автор

Киясов Андрей Павлович, автор

Мухамедшина Яна Олеговна, автор

Салафутдинов Ильнур Ильдусович, автор

Соловьева Валерия Владимировна, автор

Авторы, аспиранты КФУ

Гаранина Екатерина Евгеньевна, автор

Федотова Валерия Юрьевна, автор

Библиографическое описание на языке оригинала

Islamov R.R. Symptomatic Improvement, Increased Life-Span and Sustained Cell Homing in Amyotrophic Lateral Sclerosis After Transplantation of Human Umbilical Cord Blood Cells Genetically Modified with Adeno-Viral Vectors Expressing a Neuro-Protective Factor and a Neural Cell Adhesion Molecule / R.R. Islamov, A.A. Rizvanov, M.A. Mukhamedyarov, I.I. Salafutdinov, E.E. Garanina, V.Y. Fedotova, V.V. Solovyeva, Y.O. Mukhamedshina, Z.Z. Safiullov, A.A. Izmailov, D.S. Guseva, A.L. Zefirov, A.P. Kiyasov, A. Palotás // Current Gene Therapy. - 2015. - Vol.15, Issue 2. - P.266-276.

Аннотация

Amyotrophic lateral sclerosis (ALS) is an incurable, chronic, fatal neuro-degenerative disease characterized by progressive loss of moto-neurons and paralysis of skeletal muscles. Reactivating dysfunctional areas is under earnest investigation utilizing various approaches. Here we present an innovative gene-cell construct aimed at reviving inert structure and function. Human umbilical cord blood cells (hUCBCs) transduced with adeno-viral vectors encoding human VEGF, GDNF and/or NCAM genes were transplanted into transgenic ALS mice models. Significant improvement in behavioral performance (open-field and grip-strength tests), as well as increased life-span was observed in rodents treated with NCAM-VEGF or NCAM-GDNF co-transfected cells. Active trans-gene expression was found in the spinal cord of ALS mice 10 weeks after delivering genetically modified hUCBCs, and cells were detectable even 5 months following transplantation.

Ключевые слова

Amyotrophic Lateral Sclerosis

Название журнала

Current Gene Therapy

URL

http://www.ncbi.nlm.nih.gov/pubmed/25619885

Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку

https://repository.kpfu.ru/?p_id=98907

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Исламов Рустем Робертович	ru_RU
dc.contributor.author	Киясов Андрей Павлович	ru_RU
dc.contributor.author	Мухамедшина Яна Олеговна	ru_RU
dc.contributor.author	Салафутдинов Ильнур Ильдусович	ru_RU
dc.contributor.author	Соловьева Валерия Владимировна	ru_RU
dc.contributor.author	Гаранина Екатерина Евгеньевна	ru_RU
dc.contributor.author	Федотова Валерия Юрьевна	ru_RU
dc.date.accessioned	2015-01-01T00:00:00Z	ru_RU
dc.date.available	2015-01-01T00:00:00Z	ru_RU
dc.date.issued	2015	ru_RU
dc.identifier.citation	Islamov R.R. Symptomatic Improvement, Increased Life-Span and Sustained Cell Homing in Amyotrophic Lateral Sclerosis After Transplantation of Human Umbilical Cord Blood Cells Genetically Modified with Adeno-Viral Vectors Expressing a Neuro-Protective Factor and a Neural Cell Adhesion Molecule / R.R. Islamov, A.A. Rizvanov, M.A. Mukhamedyarov, I.I. Salafutdinov, E.E. Garanina, V.Y. Fedotova, V.V. Solovyeva, Y.O. Mukhamedshina, Z.Z. Safiullov, A.A. Izmailov, D.S. Guseva, A.L. Zefirov, A.P. Kiyasov, A. Palotás // Current Gene Therapy. - 2015. - Vol.15, Issue 2. - P.266-276.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=98907	ru_RU
dc.description.abstract	Current Gene Therapy	ru_RU
dc.description.abstract	Amyotrophic lateral sclerosis (ALS) is an incurable, chronic, fatal neuro-degenerative disease characterized by progressive loss of moto-neurons and paralysis of skeletal muscles. Reactivating dysfunctional areas is under earnest investigation utilizing various approaches. Here we present an innovative gene-cell construct aimed at reviving inert structure and function. Human umbilical cord blood cells (hUCBCs) transduced with adeno-viral vectors encoding human VEGF, GDNF and/or NCAM genes were transplanted into transgenic ALS mice models. Significant improvement in behavioral performance (open-field and grip-strength tests), as well as increased life-span was observed in rodents treated with NCAM-VEGF or NCAM-GDNF co-transfected cells. Active trans-gene expression was found in the spinal cord of ALS mice 10 weeks after delivering genetically modified hUCBCs, and cells were detectable even 5 months following transplantation.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	Symptomatic Improvement, Increased Life-Span and Sustained Cell Homing in Amyotrophic Lateral Sclerosis After Transplantation of Human Umbilical Cord Blood Cells Genetically Modified with Adeno-Viral Vectors Expressing a Neuro-Protective Factor and a Neural Cell Adhesion Molecule	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU