Казанский (Приволжский) федеральный университет, КФУ
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SYMPTOMATIC IMPROVEMENT, INCREASED LIFE-SPAN AND SUSTAINED CELL HOMING IN AMYOTROPHIC LATERAL SCLEROSIS AFTER TRANSPLANTATION OF HUMAN UMBILICAL CORD BLOOD CELLS GENETICALLY MODIFIED WITH ADENO-VIRAL VECTORS EXPRESSING A NEURO-PROTECTIVE FACTOR AND A NEURAL CELL ADHESION MOLECULE
Форма представленияСтатьи в зарубежных журналах и сборниках
Год публикации2015
Языканглийский
  • Исламов Рустем Робертович, автор
  • Киясов Андрей Павлович, автор
  • Мухамедшина Яна Олеговна, автор
  • Салафутдинов Ильнур Ильдусович, автор
  • Соловьева Валерия Владимировна, автор
  • Гаранина Екатерина Евгеньевна, автор
  • Федотова Валерия Юрьевна, автор
  • Библиографическое описание на языке оригинала Islamov R.R. Symptomatic Improvement, Increased Life-Span and Sustained Cell Homing in Amyotrophic Lateral Sclerosis After Transplantation of Human Umbilical Cord Blood Cells Genetically Modified with Adeno-Viral Vectors Expressing a Neuro-Protective Factor and a Neural Cell Adhesion Molecule / R.R. Islamov, A.A. Rizvanov, M.A. Mukhamedyarov, I.I. Salafutdinov, E.E. Garanina, V.Y. Fedotova, V.V. Solovyeva, Y.O. Mukhamedshina, Z.Z. Safiullov, A.A. Izmailov, D.S. Guseva, A.L. Zefirov, A.P. Kiyasov, A. Palotás // Current Gene Therapy. - 2015. - Vol.15, Issue 2. - P.266-276.
    Аннотация Amyotrophic lateral sclerosis (ALS) is an incurable, chronic, fatal neuro-degenerative disease characterized by progressive loss of moto-neurons and paralysis of skeletal muscles. Reactivating dysfunctional areas is under earnest investigation utilizing various approaches. Here we present an innovative gene-cell construct aimed at reviving inert structure and function. Human umbilical cord blood cells (hUCBCs) transduced with adeno-viral vectors encoding human VEGF, GDNF and/or NCAM genes were transplanted into transgenic ALS mice models. Significant improvement in behavioral performance (open-field and grip-strength tests), as well as increased life-span was observed in rodents treated with NCAM-VEGF or NCAM-GDNF co-transfected cells. Active trans-gene expression was found in the spinal cord of ALS mice 10 weeks after delivering genetically modified hUCBCs, and cells were detectable even 5 months following transplantation.
    Ключевые слова Amyotrophic Lateral Sclerosis
    Название журнала Current Gene Therapy
    URL http://www.ncbi.nlm.nih.gov/pubmed/25619885
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