KFU. Card publication. Role of K(ATP)-channels in the effects of hydrogen sulfide on the contractility of rat ventricular myocardium

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FEDERAL UNIVERSITY

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ROLE OF K(ATP)-CHANNELS IN THE EFFECTS OF HYDROGEN SULFIDE ON THE CONTRACTILITY OF RAT VENTRICULAR MYOCARDIUM

Form of presentation

Articles in international journals and collections

Year of publication

2015

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Authors, employees of KFU

Gizzatullin Almaz Rafailovich, author

Lifanova Anastasiya Sergeevna, author

Sitdikova Guzel Faritovna, author

Khaertdinov Nail Nazimovich, author

Bibliographic description in the original language

Khaertdinov N.N. Role of K(ATP)-channels in the effects of hydrogen sulfide on the contractility of rat ventricular myocardium/N.N. Khaertdinov, A.S. Lifanova, A.R. Gizzatullin, G.F. Sitdikova, //Genes and Cells. - 2015. - Vol.10, Is.4. - P.103-105.

Annotation

The effect of sodium hydrosulfide (NaHS) - donor of hydrogen sulfide (H2S) on the force of contraction of isolated rat ventricle was studied. Application of NaHS in concentrations 1 and 10 μM resulted in an increase and in concentrations 50, 100, 200 and 300 μM - dosedependent decrease of the force of contraction. Inhibition of K-channels by tetraethylammonium (15 mM) caused the increase of the amplitude of contraction and the negative inotropic effect of NaHS (200 μM) was preserved. After the activation or inhibition of ATP-dependent K-channels by diazoxide (20 μM) or glibenclamide (50 μM), respectively, the negative inotropic effect of NaHS was the same as in control. After preliminary application of NaHS glibenclamide (50 μM) reversed the contraction force to yhe control values. The obtained data suppose that in the isolated rat ventricle exogenous H2S causes a reduction of the force of contraction, which is mediated by the activation of ATPdependent K-channels.

Keywords

hydrogen sulfide, contraction, K(ATP)-channels

The name of the journal

Genes and Cells

URL

http://www.scopus.com/inward/record.url?eid=2-s2.0-84962213101&partnerID=40&md5=714bc5726d87f404e332d10597d73bd0

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=130569&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Gizzatullin Almaz Rafailovich	ru_RU
dc.contributor.author	Lifanova Anastasiya Sergeevna	ru_RU
dc.contributor.author	Sitdikova Guzel Faritovna	ru_RU
dc.contributor.author	Khaertdinov Nail Nazimovich	ru_RU
dc.date.accessioned	2015-01-01T00:00:00Z	ru_RU
dc.date.available	2015-01-01T00:00:00Z	ru_RU
dc.date.issued	2015	ru_RU
dc.identifier.citation	Khaertdinov N.N. Role of K(ATP)-channels in the effects of hydrogen sulfide on the contractility of rat ventricular myocardium/N.N. Khaertdinov, A.S. Lifanova, A.R. Gizzatullin, G.F. Sitdikova, //Genes and Cells. - 2015. - Vol.10, Is.4. - P.103-105.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=130569&p_lang=2	ru_RU
dc.description.abstract	Genes and Cells	ru_RU
dc.description.abstract	The effect of sodium hydrosulfide (NaHS) - donor of hydrogen sulfide (H2S) on the force of contraction of isolated rat ventricle was studied. Application of NaHS in concentrations 1 and 10 μM resulted in an increase and in concentrations 50, 100, 200 and 300 μM - dosedependent decrease of the force of contraction. Inhibition of K-channels by tetraethylammonium (15 mM) caused the increase of the amplitude of contraction and the negative inotropic effect of NaHS (200 μM) was preserved. After the activation or inhibition of ATP-dependent K-channels by diazoxide (20 μM) or glibenclamide (50 μM), respectively, the negative inotropic effect of NaHS was the same as in control. After preliminary application of NaHS glibenclamide (50 μM) reversed the contraction force to yhe control values. The obtained data suppose that in the isolated rat ventricle exogenous H2S causes a reduction of the force of contraction, which is mediated by the activation of ATPdependent K-channels.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	hydrogen sulfide	ru_RU
dc.subject	contraction	ru_RU
dc.subject	K(ATP)-channels	ru_RU
dc.title	Role of K(ATP)-channels in the effects of hydrogen sulfide on the contractility of rat ventricular myocardium	ru_RU
dc.type	Articles in international journals and collections	ru_RU