KFU. Card publication. Influence of Gravitational Unloading on Titin's Structure in the Rat Hind Limb Muscles

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FEDERAL UNIVERSITY

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INFLUENCE OF GRAVITATIONAL UNLOADING ON TITIN'S STRUCTURE IN THE RAT HIND LIMB MUSCLES

Form of presentation

Articles in international journals and collections

Year of publication

2016

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Authors, employees of KFU

Eremeev Anton Aleksandrovich, author

Lavrov Igor Aleksandrovich, author

Fedyanin Artur Olegovich, author

Authors, postgraduates KFU

Fedyanin Artur Olegovich, postgraduate kfu

Bibliographic description in the original language

Fedyanin A.O. Influence of Gravitational Unloading on Titin's Structure in the Rat Hind Limb Muscles / A.O. Fedyanin, A.A. Eremeev, T.V. Baltina, I.A. Lavrov //BioNanoSci. - 2016. - DOI 10.1007/s12668-016-0360-4

Annotation

The influences of microgravity lead to development of the muscular atrophy and reduction of the volume of muscle fibers, both slow and fast types, changes of the muscles structure, decrease in a muscular tone, and also endurance and general muscles functionality. This study was designed to investigate the changes of the titin's structure in m.soleusand m.extensor digitorum longusinrat after 7 days ofgravitationalunloading.Electrophysiologicalandimmunological analysis of both muscles was performed after the rats were maintained in antiortostatic position for 7 days. Results suggest that 7 days of gravitational unloading decrease the titin's intact N2A-isoform and increase titin's T2 fragment in m. soleus. At the same time no influence of gravitational unloading was found on titin's N2A-izoform in m. extensor digitorum longus. Titin reduction in m. soleus and not in m. extensor digitorum longus can suggest different mechanisms of adaptation to the gravitational changes.

Keywords

Gravityunloading, Titin, M.soleus, M.extensor digitorum longus

The name of the journal

BioNanoScience

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=143620&p_lang=2

Resource files

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Full metadata record

Field DC	Value	Language
dc.contributor.author	Eremeev Anton Aleksandrovich	ru_RU
dc.contributor.author	Lavrov Igor Aleksandrovich	ru_RU
dc.contributor.author	Fedyanin Artur Olegovich	ru_RU
dc.contributor.author	Fedyanin Artur Olegovich	ru_RU
dc.date.accessioned	2016-01-01T00:00:00Z	ru_RU
dc.date.available	2016-01-01T00:00:00Z	ru_RU
dc.date.issued	2016	ru_RU
dc.identifier.citation	Fedyanin A.O. Influence of Gravitational Unloading on Titin's Structure in the Rat Hind Limb Muscles / A.O. Fedyanin, A.A. Eremeev, T.V. Baltina, I.A. Lavrov //BioNanoSci. - 2016. - DOI 10.1007/s12668-016-0360-4	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=143620&p_lang=2	ru_RU
dc.description.abstract	BioNanoScience	ru_RU
dc.description.abstract	The influences of microgravity lead to development of the muscular atrophy and reduction of the volume of muscle fibers, both slow and fast types, changes of the muscles structure, decrease in a muscular tone, and also endurance and general muscles functionality. This study was designed to investigate the changes of the titin's structure in m.soleusand m.extensor digitorum longusinrat after 7 days ofgravitationalunloading.Electrophysiologicalandimmunological analysis of both muscles was performed after the rats were maintained in antiortostatic position for 7 days. Results suggest that 7 days of gravitational unloading decrease the titin's intact N2A-isoform and increase titin's T2 fragment in m. soleus. At the same time no influence of gravitational unloading was found on titin's N2A-izoform in m. extensor digitorum longus. Titin reduction in m. soleus and not in m. extensor digitorum longus can suggest different mechanisms of adaptation to the gravitational changes.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Gravityunloading	ru_RU
dc.subject	Titin	ru_RU
dc.subject	M.soleus	ru_RU
dc.subject	M.extensor digitorum longus	ru_RU
dc.title	Influence of Gravitational Unloading on Titin's Structure in the Rat Hind Limb Muscles	ru_RU
dc.type	Articles in international journals and collections	ru_RU