KFU. Card publication. Effect of If Current Blockade on Newborn Rat Heart Isolated According to Langendorff

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FEDERAL UNIVERSITY

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EFFECT OF IF CURRENT BLOCKADE ON NEWBORN RAT HEART ISOLATED ACCORDING TO LANGENDORFF

Form of presentation

Articles in Russian journals and collections

Year of publication

2019

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Authors, employees of KFU

Zefirov Timur Lvovich, author

Ziyatdinova Nafisa Ilgizovna, author

Kupcova Anna Mikhaylovna, author

Leonova Alina Maratovna, author

Faskhutdinov Lenar Ilsurovich, author

Other authors

Zefirov Andrey Lvovich, author

Authors, postgraduates KFU

Leonova Alina Maratovna, postgraduate kfu

Bibliographic description in the original language

Ziyatdinova N.I. Effect of If Current Blockade on Newborn Rat Heart Isolated According to Langendorff / N. I. Ziyatdinova,, A. M. Kuptsova,, L. I. Faskhutdinov, A. M. Galieva, A. L. Zefirov, T. L. Zefirov // Bulletin of Experimental Biology and Medicine, Vol. 167, N.4, r. 424-427

Annotation

The study examined the effects of hyperpolarization-activated funny current (If) on HR and coronary flow in Langendorff-isolated hearts from newborn rats. Blockade of If current with ZD7288 changed the examined cardiac parameters. The blocker in a concentration of 10—9 M decreased HR by 26.8% (p≤0.05). In concentrations 10—8, 10—7, 10—6, and 10—5 M ZD7288 produced minor differently directed effects. In a concentration of 10—5 M, ZD7288 reduced coronary flow in the isolated heart (p≤0.01). In other concentrations, the blocker produced no significant effects on coronary flow.

Keywords

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The name of the journal

Bulletin of Experimental Biology and Medicine

URL

http://www.iramn.ru/journal/bebm/2019/bbm1904.htm

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=199546&p_lang=2

Resource files

File name	Size (MB)	Format
F_BEBiM_Ziyatdinova_2019.pdf	1,72	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Zefirov Timur Lvovich	ru_RU
dc.contributor.author	Ziyatdinova Nafisa Ilgizovna	ru_RU
dc.contributor.author	Kupcova Anna Mikhaylovna	ru_RU
dc.contributor.author	Leonova Alina Maratovna	ru_RU
dc.contributor.author	Faskhutdinov Lenar Ilsurovich	ru_RU
dc.contributor.author	Zefirov Andrey Lvovich	ru_RU
dc.contributor.author	Leonova Alina Maratovna	ru_RU
dc.date.accessioned	2019-01-01T00:00:00Z	ru_RU
dc.date.available	2019-01-01T00:00:00Z	ru_RU
dc.date.issued	2019	ru_RU
dc.identifier.citation	Ziyatdinova N.I. Effect of If Current Blockade on Newborn Rat Heart Isolated According to Langendorff / N. I. Ziyatdinova,, A. M. Kuptsova,, L. I. Faskhutdinov, A. M. Galieva, A. L. Zefirov, T. L. Zefirov // Bulletin of Experimental Biology and Medicine, Vol. 167, N.4, �. 424-427	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=199546&p_lang=2	ru_RU
dc.description.abstract	Bulletin of Experimental Biology and Medicine	ru_RU
dc.description.abstract	The study examined the effects of hyperpolarization-activated funny current (If) on HR and coronary flow in Langendorff-isolated hearts from newborn rats. Blockade of If current with ZD7288 changed the examined cardiac parameters. The blocker in a concentration of 10—9 M decreased HR by 26.8% (p≤0.05). In concentrations 10—8, 10—7, 10—6, and 10—5 M ZD7288 produced minor differently directed effects. In a concentration of 10—5 M, ZD7288 reduced coronary flow in the isolated heart (p≤0.01). In other concentrations, the blocker produced no significant effects on coronary flow.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	��	ru_RU
dc.subject	��	ru_RU
dc.subject	��	ru_RU
dc.subject	��	ru_RU
dc.subject	��	ru_RU
dc.subject	��	ru_RU
dc.title	Effect of If Current Blockade on Newborn Rat Heart Isolated According to Langendorff	ru_RU
dc.type	Articles in Russian journals and collections	ru_RU