KFU. Card publication. Effect of α2-Adrenoceptor Stimulation on Cardiac Activity in Rats

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FEDERAL UNIVERSITY

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EFFECT OF α2-ADRENOCEPTOR STIMULATION ON CARDIAC ACTIVITY IN RATS

Form of presentation

Articles in Russian journals and collections

Year of publication

2014

Authors, employees of KFU

Zefirov Timur Lvovich, author

Ziyatdinova Nafisa Ilgizovna, author

Other authors

Zefirov A.L.

Authors, postgraduates KFU

Khisamieva Luiza Irekovna, postgraduate kfu

Bibliographic description in the original language

Effect of α2-Adrenoceptor Stimulation on Cardiac Activity in Rats.

Annotation

We studied the effect of α2-adrenoceptor stimulation with clonidine on BP and cardiac activity in rats. Variations in BP and chronotropism of the heart were studied in vivo after bolus injection of clonidine. In vitro experiments were performed to evaluate a dose-dependent change in myocardial contractility of the atria and ventricles after treatment with clonidine in concentrations of 10?9-10?5 M. α2-Adrenoceptor stimulation with clonidine had a negative chronotropic and inotropic effect and induced the decrease in systolic BP of rats.

Keywords

heart; chronotropism; inotropy; blood pressure; rat

The name of the journal

Bulletin of Experimental Biology and Medicine

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=91994&p_lang=2

Resource files

File name	Size (MB)	Format
Statya.2014.pdf	0,39	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Zefirov Timur Lvovich	ru_RU
dc.contributor.author	Ziyatdinova Nafisa Ilgizovna	ru_RU
dc.contributor.author	Khisamieva Luiza Irekovna	ru_RU
dc.date.accessioned	2014-01-01T00:00:00Z	ru_RU
dc.date.available	2014-01-01T00:00:00Z	ru_RU
dc.date.issued	2014	ru_RU
dc.identifier.citation	Effect of α2-Adrenoceptor Stimulation on Cardiac Activity in Rats.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=91994&p_lang=2	ru_RU
dc.description.abstract	Bulletin of Experimental Biology and Medicine	ru_RU
dc.description.abstract	We studied the effect of α2-adrenoceptor stimulation with clonidine on BP and cardiac activity in rats. Variations in BP and chronotropism of the heart were studied in vivo after bolus injection of clonidine. In vitro experiments were performed to evaluate a dose-dependent change in myocardial contractility of the atria and ventricles after treatment with clonidine in concentrations of 10?9-10?5 M. α2-Adrenoceptor stimulation with clonidine had a negative chronotropic and inotropic effect and induced the decrease in systolic BP of rats.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	Effect of α2-Adrenoceptor Stimulation on Cardiac Activity in Rats	ru_RU
dc.type	Articles in Russian journals and collections	ru_RU