| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2015 |
|
Будников Герман Константинович, автор
Евтюгин Геннадий Артурович, автор
Порфирьева Анна Вениаминовна, автор
Степанова Вероника Борисовна, автор
|
| Библиографическое описание на языке оригинала |
Evtugyn, G. Electrochemical biosensors based on native DNA and nanosized mediator for the detection of anthracycline preparations [Text] / G.Evtugyn, A.Porfireva, V.Stepanova, H.Budnikov // Electroanalysis- 2015.- V.27, N2.- P.629-637. |
| Аннотация |
A novel electrochemical DNA-sensor based on glassy carbon electrode (GCE) modified with electropolymerized Neutral red (NR) and polycarboxylated thiacax[4]arene with covalently attached mediator and electrostatically adsorbed DNA was developed for sensitive detection of anthracycline preparations. Intercalation of doxorubicin, daunorubicin and idarubicin into DNA increases the charge transfer resistance and decreases the electron exchange resulted in decay of the cathodic peak of NR reduction. The DNA-sensor developed makes it possible to determine down to 0.05 nM doxorubicin, o.1 nM doxorubicin and 0.5 nM idarubicin. The DNA-sensor was tested on detection of doxorubicin in pharmaceuticals and artificial blood plasma with 95?100 % recovery. |
| Ключевые слова |
DNA sensor, Anthracycline pharmaceuticals, Poly(Neutral red), Nanosized mediator, Electrochemical impedance |
| Название журнала |
ELECTROANAL
|
| URL |
http://onlinelibrary.wiley.com/doi/10.1002/elan.201400564/abstract |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=104406 |
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Будников Герман Константинович |
ru_RU |
| dc.contributor.author |
Евтюгин Геннадий Артурович |
ru_RU |
| dc.contributor.author |
Порфирьева Анна Вениаминовна |
ru_RU |
| dc.contributor.author |
Степанова Вероника Борисовна |
ru_RU |
| dc.date.accessioned |
2015-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2015-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2015 |
ru_RU |
| dc.identifier.citation |
Evtugyn, G. Electrochemical biosensors based on native DNA and nanosized mediator for the detection of anthracycline preparations [Text] / G.Evtugyn, A.Porfireva, V.Stepanova, H.Budnikov // Electroanalysis- 2015.- V.27, N2.- P.629-637. |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=104406 |
ru_RU |
| dc.description.abstract |
ELECTROANAL |
ru_RU |
| dc.description.abstract |
A novel electrochemical DNA-sensor based on glassy carbon electrode (GCE) modified with electropolymerized Neutral red (NR) and polycarboxylated thiacax[4]arene with covalently attached mediator and electrostatically adsorbed DNA was developed for sensitive detection of anthracycline preparations. Intercalation of doxorubicin, daunorubicin and idarubicin into DNA increases the charge transfer resistance and decreases the electron exchange resulted in decay of the cathodic peak of NR reduction. The DNA-sensor developed makes it possible to determine down to 0.05 nM doxorubicin, o.1 nM doxorubicin and 0.5 nM idarubicin. The DNA-sensor was tested on detection of doxorubicin in pharmaceuticals and artificial blood plasma with 95?100 % recovery. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
DNA sensor |
ru_RU |
| dc.subject |
Anthracycline pharmaceuticals |
ru_RU |
| dc.subject |
Poly(Neutral red) |
ru_RU |
| dc.subject |
Nanosized mediator |
ru_RU |
| dc.subject |
Electrochemical impedance |
ru_RU |
| dc.title |
Electrochemical biosensors based on native DNA and nanosized mediator for the detection of anthracycline preparations. |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
|
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