КФУ. Карточка публикации. echanisms of Hydrogen Sulfide (H2S) Action on Synaptic Transmission at the Mouse Neuromuscular Junction

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ECHANISMS OF HYDROGEN SULFIDE (H2S) ACTION ON SYNAPTIC TRANSMISSION AT THE MOUSE NEUROMUSCULAR JUNCTION

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2015

Язык

английский

Авторы, сотрудники КФУ

Герасимова Елена Вячеславовна, автор

Гиниатуллин Рашид Асхатович, автор

Ситдикова Гузель Фаритовна, автор

Яковлев Алексей Валерьевич, автор

Библиографическое описание на языке оригинала

Gerasimova E. Mechanisms of Hydrogen Sulfide (H2S) Action on Synaptic Transmission at the Mouse Neuromuscular Junction / Gerasimova E., Lebedeva J., Yakovlev A., Zefirov A., Giniatullin R., Sitdikova G. // Neuroscience. - 2015

Аннотация

Hydrogen sulfide (H2S) is a widespread gasotransmitter known also as a powerful neuroprotective agent in the central nervous system. However, the action of H2S in peripheral synapses is much less studied. In the current project we studied the modulatory effects of the H2S donor sodium hydrogen sulfide (NaHS) on synaptic transmission in the mouse neuromuscular junction using microelectrode technique. Using focal recordings of presynaptic response and evoked transmitter release we have shown that NaHS (300 μM) increased evoked endplate currents (EPCs) without changes of presynaptic waveforms which indicated the absence of NaHS effects on sodium and potassium currents of motor nerve endings. Using intracellular recordings it was shown that NaHS increased the frequency of miniature endplate potentials (MEPPs) without changing their amplitudes indicating a pure presynaptic effect. Furthermore, NaHS increased the amplitude of endplate potentials (EPPs) without influence on the resting membra

Ключевые слова

Hydrogen sulfide; Neuromuscular junction; Transmitter release; L-cysteine; Adenylate cyclase; Ryanodine receptors

Название журнала

NEUROSCIENCE

URL

http://www.sciencedirect.com/science/article/pii/S0306452215006508

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https://repository.kpfu.ru/?p_id=111118

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Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Герасимова Елена Вячеславовна	ru_RU
dc.contributor.author	Гиниатуллин Рашид Асхатович	ru_RU
dc.contributor.author	Ситдикова Гузель Фаритовна	ru_RU
dc.contributor.author	Яковлев Алексей Валерьевич	ru_RU
dc.date.accessioned	2015-01-01T00:00:00Z	ru_RU
dc.date.available	2015-01-01T00:00:00Z	ru_RU
dc.date.issued	2015	ru_RU
dc.identifier.citation	Gerasimova E. Mechanisms of Hydrogen Sulfide (H2S) Action on Synaptic Transmission at the Mouse Neuromuscular Junction / Gerasimova E., Lebedeva J., Yakovlev A., Zefirov A., Giniatullin R., Sitdikova G. // Neuroscience. - 2015	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=111118	ru_RU
dc.description.abstract	NEUROSCIENCE	ru_RU
dc.description.abstract	Hydrogen sulfide (H2S) is a widespread gasotransmitter known also as a powerful neuroprotective agent in the central nervous system. However, the action of H2S in peripheral synapses is much less studied. In the current project we studied the modulatory effects of the H2S donor sodium hydrogen sulfide (NaHS) on synaptic transmission in the mouse neuromuscular junction using microelectrode technique. Using focal recordings of presynaptic response and evoked transmitter release we have shown that NaHS (300 μM) increased evoked endplate currents (EPCs) without changes of presynaptic waveforms which indicated the absence of NaHS effects on sodium and potassium currents of motor nerve endings. Using intracellular recordings it was shown that NaHS increased the frequency of miniature endplate potentials (MEPPs) without changing their amplitudes indicating a pure presynaptic effect. Furthermore, NaHS increased the amplitude of endplate potentials (EPPs) without influence on the resting membra	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	echanisms of Hydrogen Sulfide (H2S) Action on Synaptic Transmission at the Mouse Neuromuscular Junction	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU