КФУ. Карточка публикации. Computational modelling elucidates the mechanism of ciliary regulation in health and disease / Kotov NV, Bates DG, Gizatullina AN, Gilaziev B, Khairullin RN, Chen MZ, Drozdov I, Umezawa Y, Hundhausen C, Aleksandrov A, Yan XG, Spurgeon SK, Smales CM, Valeyev NV. //BMC Syst Biol. 2011 Sep 15;5:143. doi: 10.1186/1752-0509-5-143.

RUS

- EN
- 中文
- ES

COMPUTATIONAL MODELLING ELUCIDATES THE MECHANISM OF CILIARY REGULATION IN HEALTH AND DISEASE / KOTOV NV, BATES DG, GIZATULLINA AN, GILAZIEV B, KHAIRULLIN RN, CHEN MZ, DROZDOV I, UMEZAWA Y, HUNDHAUSEN C, ALEKSANDROV A, YAN XG, SPURGEON SK, SMALES CM, VALEYEV NV. //BMC SYST BIOL. 2011 SEP 15;5:143. DOI: 10.1186/1752-0509-5-143.

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2011

Язык

английский

Авторы, сотрудники КФУ

Базановас Антонина Николаевна, автор

Котов Николай Викторович, автор

Другие авторы

Valeyev Najl Valievich, автор

Библиографическое описание на языке оригинала

Computational modelling elucidates the mechanism of ciliary regulation in health and disease. Kotov NV1, Bates DG, Gizatullina AN, Gilaziev B, Khairullin RN, Chen MZ, Drozdov I, Umezawa Y, Hundhausen C, Aleksandrov A, Yan XG, Spurgeon SK, Smales CM, Valeyev NV

Аннотация

Ciliary dysfunction leads to a number of human pathologies, including primary ciliary dyskinesia, nephronophthisis, situs inversus pathology or infertility. The mechanism of cilia beating regulation is complex and despite extensive experimental characterization remains poorly understood. We develop a detailed systems model for calcium, membrane potential and cyclic nucleotide-dependent ciliary motility regulation. The model describes the intimate relationship between calcium and potassium ionic concentrations inside and outside of cilia with membrane voltage and, for the first time, describes a novel type of ciliary excitability which plays the major role in ciliary movement regulation. Our model describes a mechanism that allows ciliary excitation to be robust over a wide physiological range of extracellular ionic concentrations. The model predicts the existence of several dynamic modes of ciliary regulation.

Ключевые слова

кальций, кальмодулин, ресничка, каналы

Название журнала

BMC SYSTEMS BIOLOGY

URL

http://www.biomedcentral.com/1752-0509/5/143

Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку

https://repository.kpfu.ru/?p_id=115066

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Базановас Антонина Николаевна	ru_RU
dc.contributor.author	Котов Николай Викторович	ru_RU
dc.contributor.author	Valeyev Najl Valievich	ru_RU
dc.date.accessioned	2011-01-01T00:00:00Z	ru_RU
dc.date.available	2011-01-01T00:00:00Z	ru_RU
dc.date.issued	2011	ru_RU
dc.identifier.citation	Computational modelling elucidates the mechanism of ciliary regulation in health and disease. Kotov NV1, Bates DG, Gizatullina AN, Gilaziev B, Khairullin RN, Chen MZ, Drozdov I, Umezawa Y, Hundhausen C, Aleksandrov A, Yan XG, Spurgeon SK, Smales CM, Valeyev NV	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=115066	ru_RU
dc.description.abstract	BMC SYSTEMS BIOLOGY	ru_RU
dc.description.abstract	Ciliary dysfunction leads to a number of human pathologies, including primary ciliary dyskinesia, nephronophthisis, situs inversus pathology or infertility. The mechanism of cilia beating regulation is complex and despite extensive experimental characterization remains poorly understood. We develop a detailed systems model for calcium, membrane potential and cyclic nucleotide-dependent ciliary motility regulation. The model describes the intimate relationship between calcium and potassium ionic concentrations inside and outside of cilia with membrane voltage and, for the first time, describes a novel type of ciliary excitability which plays the major role in ciliary movement regulation. Our model describes a mechanism that allows ciliary excitation to be robust over a wide physiological range of extracellular ionic concentrations. The model predicts the existence of several dynamic modes of ciliary regulation.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	кальций	ru_RU
dc.subject	кальмодулин	ru_RU
dc.subject	ресничка	ru_RU
dc.subject	каналы	ru_RU
dc.title	Computational modelling elucidates the mechanism of ciliary regulation in health and disease / Kotov NV, Bates DG, Gizatullina AN, Gilaziev B, Khairullin RN, Chen MZ, Drozdov I, Umezawa Y, Hundhausen C, Aleksandrov A, Yan XG, Spurgeon SK, Smales CM, Valeyev NV. //BMC Syst Biol. 2011 Sep 15;5:143. doi: 10.1186/1752-0509-5-143.	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU