КФУ. Карточка публикации. Dynamics and thermodynamic properties of CXCL7 chemokine

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DYNAMICS AND THERMODYNAMIC PROPERTIES OF CXCL7 CHEMOKINE

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2015

Язык

английский

Авторы, сотрудники КФУ

Хайрутдинов Булат Имамутдинович, автор

Другие авторы

Ermakova Elena Andreevna, автор

Nesmelova Irina Vyacheslavovna, автор

Zuev Yuriy Fedorovich, автор

Библиографическое описание на языке оригинала

Herring C.А. Dynamics and thermodynamic properties of CXCL7 chemokine [Текст] / Charles A. Herring, Christopher M. Singer1, Elena A. Ermakova, Bulat I. Khairutdinov, Yuriy F. Zuev, Donald J. Jacobs and Irina V. Nesmelova // Proteins: Structure, Function, and Bioinformatics. – 2015. Vol. 83. – P. 1987-2007

Аннотация

Chemokines form a family of signaling proteins mainly responsible for directing the traffic of leukocytes, where their biological activity can be modulated by their oligomerization state. We characterize the dynamics and thermodynamic stability of monomer and homodimer structures of CXCL7, one of the most abundant platelet chemokines, using experimental methods that include circular dichroism (CD) and nuclear magnetic resonance (NMR) spectroscopy, and computational methods that include the anisotropic network model (ANM), molecular dynamics (MD) simulations and the distance constraint model (DCM). A consistent picture emerges for the effects of dimerization and Cys5-Cys31 and Cys7-Cys47 disulfide bonds formation. The presence of disulfide bonds is not critical for maintaining structural stability in the monomer or dimer, but the monomer is destabilized more than the dimer upon removal of disulfide bonds. Disulfide bonds play a key role in shaping the characteristics of native state dyn

Ключевые слова

chemokine; CXCL7; dimer; thermal unfolding; CD spectroscopy; disulfide bonds; distance constraint model; dynamics

Название журнала

Proteins: Structure, Function, and Bioinformatics

Ссылка для РПД

http://dspace.kpfu.ru/xmlui/bitstream/handle/net/32500/2015_prot24913.pdf?sequence=1&isAllowed=y

URL

http://onlinelibrary.wiley.com/doi/10.1002/prot.24913/full

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https://repository.kpfu.ru/?p_id=120284

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Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Хайрутдинов Булат Имамутдинович	ru_RU
dc.contributor.author	Ermakova Elena Andreevna	ru_RU
dc.contributor.author	Nesmelova Irina Vyacheslavovna	ru_RU
dc.contributor.author	Zuev Yuriy Fedorovich	ru_RU
dc.date.accessioned	2015-01-01T00:00:00Z	ru_RU
dc.date.available	2015-01-01T00:00:00Z	ru_RU
dc.date.issued	2015	ru_RU
dc.identifier.citation	Herring C.А. Dynamics and thermodynamic properties of CXCL7 chemokine [Текст] / Charles A. Herring, Christopher M. Singer1, Elena A. Ermakova, Bulat I. Khairutdinov, Yuriy F. Zuev, Donald J. Jacobs and Irina V. Nesmelova // Proteins: Structure, Function, and Bioinformatics. – 2015. Vol. 83. – P. 1987-2007	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=120284	ru_RU
dc.description.abstract	Proteins: Structure, Function, and Bioinformatics	ru_RU
dc.description.abstract	Chemokines form a family of signaling proteins mainly responsible for directing the traffic of leukocytes, where their biological activity can be modulated by their oligomerization state. We characterize the dynamics and thermodynamic stability of monomer and homodimer structures of CXCL7, one of the most abundant platelet chemokines, using experimental methods that include circular dichroism (CD) and nuclear magnetic resonance (NMR) spectroscopy, and computational methods that include the anisotropic network model (ANM), molecular dynamics (MD) simulations and the distance constraint model (DCM). A consistent picture emerges for the effects of dimerization and Cys5-Cys31 and Cys7-Cys47 disulfide bonds formation. The presence of disulfide bonds is not critical for maintaining structural stability in the monomer or dimer, but the monomer is destabilized more than the dimer upon removal of disulfide bonds. Disulfide bonds play a key role in shaping the characteristics of native state dyn	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	Dynamics and thermodynamic properties of CXCL7 chemokine	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU