| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2016 |
| Язык | английский |
|
Зуева Ирина Владимировна, автор
Массон Патрик Ивон Морис , автор
Мустафина Асия Рафаэлевна, автор
Мухаметшина Алсу Рустэмовна, автор
Петров Константин Александрович, автор
|
|
Мухаметшина Алсу Рустэмовна, автор
|
| Библиографическое описание на языке оригинала |
Mukhametshina A.R. Luminescent silica nanoparticles for sensing acetylcholinesterase-catalyzed hydrolysis of acetylcholine / A. R. Mukhametshina, S. V. Fedorenko, I. V. Zueva, K. A. Petrov, P. Masson, I. R. Nizameev, A. R. Mustafina, O.G. Sinyashin // Biosensors and Bioelectronics. - 2016. - V. 77. - P. 871-878. |
| Аннотация |
This work highlights the H-function of Tb(III)-doped silica nanoparticles in aqueous solutions of acetic acid as a route to sense acetylcholinesterase-catalyzed hydrolysis of acetylcholine (ACh). The H-function results from H+-induced quenching of Tb(III)-centered luminescence due to protonation of Tb(III) complexes located close to silica/water interface. The H-function can be turned on/switched off by the concentration of complexes within core or nanoparticle shell zones, by the silica surface decoration and adsorption of both organic and inorganic cations on silica surface. Results indicate the optimal synthetic procedure for making nanoparticles capable of sensing acetic acid produced by enzymatic hydrolysis of acetylcholine. The H-function of nanoparticles was determined at various concentrations of ACh and AChE. The measurements show experimental conditions for fitting the H-function to Michaelis-Menten kinetics. Results confirm that reliable fluorescent monitoring AChE-catalyzed |
| Ключевые слова |
Acetylcholinesterase, Acetylcholine, Enzymatic hydrolysis, Silica nanoparticles, Luminescence, Tb(III) complex |
| Название журнала |
Biosensors and Bioelectronics
|
| URL |
http://www.sciencedirect.com/science/article/pii/S0956566315305200 |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=122103 |
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Зуева Ирина Владимировна |
ru_RU |
| dc.contributor.author |
Массон Патрик Ивон Морис |
ru_RU |
| dc.contributor.author |
Мустафина Асия Рафаэлевна |
ru_RU |
| dc.contributor.author |
Мухаметшина Алсу Рустэмовна |
ru_RU |
| dc.contributor.author |
Петров Константин Александрович |
ru_RU |
| dc.contributor.author |
Мухаметшина Алсу Рустэмовна |
ru_RU |
| dc.date.accessioned |
2016-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2016-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2016 |
ru_RU |
| dc.identifier.citation |
Mukhametshina A.R. Luminescent silica nanoparticles for sensing acetylcholinesterase-catalyzed hydrolysis of acetylcholine / A. R. Mukhametshina, S. V. Fedorenko, I. V. Zueva, K. A. Petrov, P. Masson, I. R. Nizameev, A. R. Mustafina, O.G. Sinyashin // Biosensors and Bioelectronics. - 2016. - V. 77. - P. 871-878. |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=122103 |
ru_RU |
| dc.description.abstract |
Biosensors and Bioelectronics |
ru_RU |
| dc.description.abstract |
This work highlights the H-function of Tb(III)-doped silica nanoparticles in aqueous solutions of acetic acid as a route to sense acetylcholinesterase-catalyzed hydrolysis of acetylcholine (ACh). The H-function results from H+-induced quenching of Tb(III)-centered luminescence due to protonation of Tb(III) complexes located close to silica/water interface. The H-function can be turned on/switched off by the concentration of complexes within core or nanoparticle shell zones, by the silica surface decoration and adsorption of both organic and inorganic cations on silica surface. Results indicate the optimal synthetic procedure for making nanoparticles capable of sensing acetic acid produced by enzymatic hydrolysis of acetylcholine. The H-function of nanoparticles was determined at various concentrations of ACh and AChE. The measurements show experimental conditions for fitting the H-function to Michaelis-Menten kinetics. Results confirm that reliable fluorescent monitoring AChE-catalyzed |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
Acetylcholinesterase |
ru_RU |
| dc.subject |
Acetylcholine |
ru_RU |
| dc.subject |
Enzymatic hydrolysis |
ru_RU |
| dc.subject |
Silica nanoparticles |
ru_RU |
| dc.subject |
Luminescence |
ru_RU |
| dc.subject |
Tb(III) complex |
ru_RU |
| dc.title |
Luminescent silica nanoparticles for sensing acetylcholinesterase-catalyzed hydrolysis of acetylcholine |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
|
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