КФУ. Карточка публикации. Uncatalyzed click reaction between phenyl azides and acrolein: 4-formyl-1,2,3-triazolines as “clicked” markers for visualizations of extracellular acrolein released from oxidatively stressed cells

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UNCATALYZED CLICK REACTION BETWEEN PHENYL AZIDES AND ACROLEIN: 4-FORMYL-1,2,3-TRIAZOLINES AS &LDQUO;CLICKED&RDQUO; MARKERS FOR VISUALIZATIONS OF EXTRACELLULAR ACROLEIN RELEASED FROM OXIDATIVELY STRESSED CELLS

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2016

Язык

английский

Авторы, сотрудники КФУ

Курбангалиева Альмира Рафаэловна, автор

Сайгитбаталова Елена Шириповна, автор

Авторы, аспиранты КФУ

Сайгитбаталова Елена Шириповна, автор

Библиографическое описание на языке оригинала

Pradipta A. R. Uncatalyzed click reaction between phenyl azides and acrolein: 4-formyl-1,2,3-triazolines as “clicked” markers for visualizations of extracellular acrolein released from oxidatively stressed cells / A. R. Pradipta, M. Taichi, I. Nakase, E. Saigitbatalova, A. Kurbangalieva, S. Kitazume, N. Taniguchi, K. Tanaka // ACS Sens. - 2016. - V. 1. - № 5. - P. 623-632.

Аннотация

Acrolein, a highly toxic α,β-unsaturated aldehyde, has been a longstanding key biomarker associated with a range of disorders related to oxidative stresses. Currently available analytical methods rely on the indirect protocols, e.g., derivatization/HPLC or mAb detection of the lysine adducts. Consequently, developing new analytical tools for acrolein detection that are straightforward, cost-effective, selective, and preferably feasible using live cells remains a highly essential pursuit in the diagnosis and therapeutic treatment of oxidative stress-related diseases. We demonstrated that for the first time aryl azides can rapidly and selectively react with acrolein in a ?click? manner to provide 4-formyl-1,2,3-triazolines and 4-formyl-1,2,3-triazoles, which represents an unexplored reactivity of aryl azides.

Ключевые слова

acrolein, aryl azide, oxidative stress, cell imaging, click chemistry

Название журнала

ACS Sensors

URL

http://pubs.acs.org/doi/abs/10.1021/acssensors.6b00122

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https://repository.kpfu.ru/?p_id=128200

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Курбангалиева Альмира Рафаэловна	ru_RU
dc.contributor.author	Сайгитбаталова Елена Шириповна	ru_RU
dc.contributor.author	Сайгитбаталова Елена Шириповна	ru_RU
dc.date.accessioned	2016-01-01T00:00:00Z	ru_RU
dc.date.available	2016-01-01T00:00:00Z	ru_RU
dc.date.issued	2016	ru_RU
dc.identifier.citation	Pradipta A. R. Uncatalyzed click reaction between phenyl azides and acrolein: 4-formyl-1,2,3-triazolines as “clicked” markers for visualizations of extracellular acrolein released from oxidatively stressed cells / A. R. Pradipta, M. Taichi, I. Nakase, E. Saigitbatalova, A. Kurbangalieva, S. Kitazume, N. Taniguchi, K. Tanaka // ACS Sens. - 2016. - V. 1. - № 5. - P. 623-632.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=128200	ru_RU
dc.description.abstract	ACS Sensors	ru_RU
dc.description.abstract	Acrolein, a highly toxic α,β-unsaturated aldehyde, has been a longstanding key biomarker associated with a range of disorders related to oxidative stresses. Currently available analytical methods rely on the indirect protocols, e.g., derivatization/HPLC or mAb detection of the lysine adducts. Consequently, developing new analytical tools for acrolein detection that are straightforward, cost-effective, selective, and preferably feasible using live cells remains a highly essential pursuit in the diagnosis and therapeutic treatment of oxidative stress-related diseases. We demonstrated that for the first time aryl azides can rapidly and selectively react with acrolein in a ?click? manner to provide 4-formyl-1,2,3-triazolines and 4-formyl-1,2,3-triazoles, which represents an unexplored reactivity of aryl azides.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	acrolein	ru_RU
dc.subject	aryl azide	ru_RU
dc.subject	oxidative stress	ru_RU
dc.subject	cell imaging	ru_RU
dc.subject	click chemistry	ru_RU
dc.title	Uncatalyzed click reaction between phenyl azides and acrolein: 4-formyl-1,2,3-triazolines as “clicked” markers for visualizations of extracellular acrolein released from oxidatively stressed cells	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU