КФУ. Карточка публикации. Full-genome study of gene expression in lumbar spinal cord of mice after 30-day space flight on Bion-M1 biosatellite

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FULL-GENOME STUDY OF GENE EXPRESSION IN LUMBAR SPINAL CORD OF MICE AFTER 30-DAY SPACE FLIGHT ON BION-M1 BIOSATELLITE

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2016

Язык

английский

Авторы, сотрудники КФУ

Гусев Олег Александрович, автор

Петров Константин Александрович, автор

Ризванов Альберт Анатольевич, автор

Тяпкина Оксана Викторовна, автор

Библиографическое описание на языке оригинала

Islamov R.R. Full-genome study of gene expression in lumbar spinal cord of mice after 30-day space flight on Bion-M1 biosatellite /R.R. Islamov, O.A. Gusev, A. Tanabe, M. Terada, O.V. Tyapkina, K.A. Petrov, A.A. Rizvanov, I.B. Kozlovskaya, E.E. Nikolskiy, A.I. Grigorjev // Acta Astronautica, Volume 122, 2016, Pages 231-236

Аннотация

Experiments were conducted on male mice of the C57BL/6J for full genome study of gene expression. The animals were divided into two groups.The 'flight group' mice that had spent 30 days in space and the 'control group' mice that stayed on Earth. The spinal cord of the 'flight' group mice as extracted 14h following the biosatellite's landing. The spinal cord of the control group mice was extracted at the same time.Then the lumbar spinal cord was frozen in liquid nitrogen and kept until the beginning of the study at -80?C. Quality control of the feature was performed using the settings recommended by Agilent Technologies. Signal background was subtracted and the signal intensity of each gene was globally normalized using locally weighted scatterplot smoothing. The analysis suggests that various functional groups of genes in different types of cells in spinal cord may be involved in the development of HLS and some changes in gene expression certainly happened in motor neurons innervating

Ключевые слова

Bion-M1 biosatellite

Название журнала

Acta Astronautica

URL

http://www.scopus.com/inward/record.url?eid=2-s2.0-84958982369&partnerID=40&md5=72cba688a263281a3d8766aeb4ca8e42

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https://repository.kpfu.ru/?p_id=135547

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Гусев Олег Александрович	ru_RU
dc.contributor.author	Петров Константин Александрович	ru_RU
dc.contributor.author	Ризванов Альберт Анатольевич	ru_RU
dc.contributor.author	Тяпкина Оксана Викторовна	ru_RU
dc.date.accessioned	2016-01-01T00:00:00Z	ru_RU
dc.date.available	2016-01-01T00:00:00Z	ru_RU
dc.date.issued	2016	ru_RU
dc.identifier.citation	Islamov R.R. Full-genome study of gene expression in lumbar spinal cord of mice after 30-day space flight on Bion-M1 biosatellite /R.R. Islamov, O.A. Gusev, A. Tanabe, M. Terada, O.V. Tyapkina, K.A. Petrov, A.A. Rizvanov, I.B. Kozlovskaya, E.E. Nikolskiy, A.I. Grigorjev // Acta Astronautica, Volume 122, 2016, Pages 231-236	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=135547	ru_RU
dc.description.abstract	Acta Astronautica	ru_RU
dc.description.abstract	Experiments were conducted on male mice of the C57BL/6J for full genome study of gene expression. The animals were divided into two groups.The 'flight group' mice that had spent 30 days in space and the 'control group' mice that stayed on Earth. The spinal cord of the 'flight' group mice as extracted 14h following the biosatellite's landing. The spinal cord of the control group mice was extracted at the same time.Then the lumbar spinal cord was frozen in liquid nitrogen and kept until the beginning of the study at -80?C. Quality control of the feature was performed using the settings recommended by Agilent Technologies. Signal background was subtracted and the signal intensity of each gene was globally normalized using locally weighted scatterplot smoothing. The analysis suggests that various functional groups of genes in different types of cells in spinal cord may be involved in the development of HLS and some changes in gene expression certainly happened in motor neurons innervating	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	Full-genome study of gene expression in lumbar spinal cord of mice after 30-day space flight on Bion-M1 biosatellite	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU