КФУ. Карточка публикации. GABAergic Synchronization in Epilepsy

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GABAERGIC SYNCHRONIZATION IN EPILEPSY

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2016

Язык

английский

Авторы, сотрудники КФУ

Хазипов Рустем Нариманович, автор

Библиографическое описание на языке оригинала

Khazipov R. GABAergic Synchronization in Epilepsy / R. Khazipov // Cold Spring Harb Perspect Med. - Vol. 6. - № 2. - Р. 1-13.

Аннотация

γ-Aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the cerebral cortex. GABAergic inhibition enables synchronization of activity in cortical networks, and contributes to generation of variety of brain activity patterns. In relation to epilepsy, GABAergic inhibition has been traditionally viewed as the main mechanism counterbalancing glutamatergic excitation and preventing hypersynchronous neuronal discharges. Indeed, deficits in GABAergic functions most commonly result in a hyperexcitable epileptic state, and many of the currently used antiepileptic drugs act through enhancement of GABAergic functions. However, a number of observations show that some epileptiform activity patterns involve synchronization by GABAergic mechanisms. These include two main categories that will be reviewed here: (1) synchronization of epileptiform oscillations based on GABAergic inhibition, and (2) epileptiform events driven by depolarizing and excitatory GABA. The conclusion is reached th

Ключевые слова

GABA, epilepsy, development

Название журнала

Cold Spring Harb Perspect Med

URL

http://perspectivesinmedicine.cshlp.org/cgi/pmidlookup?view=long&pmid=26747834

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https://repository.kpfu.ru/?p_id=135716

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Khazipov_Cold_Spring_Harb_Perspect_Med_2016_Khazipov_cshperspect.a022764.pdf	0,74	pdf	посмотреть / скачать

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Хазипов Рустем Нариманович	ru_RU
dc.date.accessioned	2016-01-01T00:00:00Z	ru_RU
dc.date.available	2016-01-01T00:00:00Z	ru_RU
dc.date.issued	2016	ru_RU
dc.identifier.citation	Khazipov R. GABAergic Synchronization in Epilepsy / R. Khazipov // Cold Spring Harb Perspect Med. - Vol. 6. - № 2. - Р. 1-13.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=135716	ru_RU
dc.description.abstract	Cold Spring Harb Perspect Med	ru_RU
dc.description.abstract	γ-Aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the cerebral cortex. GABAergic inhibition enables synchronization of activity in cortical networks, and contributes to generation of variety of brain activity patterns. In relation to epilepsy, GABAergic inhibition has been traditionally viewed as the main mechanism counterbalancing glutamatergic excitation and preventing hypersynchronous neuronal discharges. Indeed, deficits in GABAergic functions most commonly result in a hyperexcitable epileptic state, and many of the currently used antiepileptic drugs act through enhancement of GABAergic functions. However, a number of observations show that some epileptiform activity patterns involve synchronization by GABAergic mechanisms. These include two main categories that will be reviewed here: (1) synchronization of epileptiform oscillations based on GABAergic inhibition, and (2) epileptiform events driven by depolarizing and excitatory GABA. The conclusion is reached th	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	GABA	ru_RU
dc.subject	epilepsy	ru_RU
dc.subject	development	ru_RU
dc.title	GABAergic Synchronization in Epilepsy	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU